{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,20]],"date-time":"2026-06-20T05:50:33Z","timestamp":1781934633676,"version":"3.54.5"},"reference-count":14,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2026,4,14]],"date-time":"2026-04-14T00:00:00Z","timestamp":1776124800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"},{"start":{"date-parts":[[2026,4,14]],"date-time":"2026-04-14T00:00:00Z","timestamp":1776124800000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Muscle and Nerve"],"published-print":{"date-parts":[[2026,7]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Introduction\/Aims<\/jats:title>\n                    <jats:p>The distinct ultrasonographic and electrophysiological features separating typical chronic inflammatory demyelinating polyneuropathy (CIDP) from its motor\u2010predominant and pure motor variants remain poorly defined. We aimed to characterize the ultrasonographic, electrophysiological, and clinical features of these CIDP subtypes within a Chinese cohort.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>Between March 2015 and January 2025, we prospectively enrolled consecutive patients meeting the 2021 European Academy of Neurology\/Peripheral Nerve Society (EAN\/PNS) diagnostic criteria for CIDP. All participants underwent standardized nerve ultrasound and nerve conduction studies (NCS).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>A total of 206 CIDP patients were recruited, including 145 with typical CIDP, 10 with motor\u2010predominant CIDP, and 8 with motor CIDP. Significant nerve enlargement was present in 34 (23.4%) of typical, one (10%) of motor\u2010predominant, and none of motor CIDP patients. Cross\u2010sectional areas (CSAs) at most upper limb nerve sites were significantly larger in motor\u2010predominant than in motor CIDP. Electrophysiologically, motor nerve conduction velocities (MCVs) of upper limb nerves were slower in motor\u2010predominant CIDP than in motor CIDP, and were also slower in distal segments in typical CIDP compared to motor\u2010predominant CIDP. Corticosteroid responsiveness demonstrated a clear declining trend across the subtypes: 93.8% (106\/113) in typical, 85.7% (6\/7) in motor\u2010predominant, and 50% (3\/6) in motor CIDP.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Discussion<\/jats:title>\n                    <jats:p>Our findings support the concept of a disease spectrum from typical to motor CIDP, characterized by progressively decreasing nerve CSA enlargement on ultrasound, less prominent demyelinating features on NCS, and a diminished therapeutic response to corticosteroids.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1002\/mus.70242","type":"journal-article","created":{"date-parts":[[2026,4,15]],"date-time":"2026-04-15T01:37:37Z","timestamp":1776217057000},"page":"30-37","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Ultrasonographic, Electrophysiological and Clinical Profiles of Motor and Motor Predominant Chronic Inflammatory Demyelinating Polyneuropathy"],"prefix":"10.1002","volume":"74","author":[{"given":"Jingwen","family":"Niu","sequence":"first","affiliation":[{"name":"Department of Neurology Peking Union Medical College Hospital, Chinese Academy of Medical Sciences  Beijing China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Qingyun","family":"Ding","sequence":"additional","affiliation":[{"name":"Department of Neurology Peking Union Medical College Hospital, Chinese Academy of Medical Sciences  Beijing China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4046-8439","authenticated-orcid":false,"given":"Nan","family":"Hu","sequence":"additional","affiliation":[{"name":"Department of Neurology Peking Union Medical College Hospital, Chinese Academy of Medical Sciences  Beijing China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Liying","family":"Cui","sequence":"additional","affiliation":[{"name":"Department of Neurology Peking Union Medical College Hospital, Chinese Academy of Medical Sciences  Beijing China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0257-5345","authenticated-orcid":false,"given":"Mingsheng","family":"Liu","sequence":"additional","affiliation":[{"name":"Department of Neurology Peking Union Medical College Hospital, Chinese Academy of Medical Sciences  Beijing China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2026,4,14]]},"reference":[{"key":"e_1_2_12_2_1","doi-asserted-by":"publisher","DOI":"10.1111\/ene.14959"},{"key":"e_1_2_12_3_1","doi-asserted-by":"publisher","DOI":"10.1136\/jnnp-2018-318714"},{"key":"e_1_2_12_4_1","doi-asserted-by":"publisher","DOI":"10.1136\/jnnp-2019-320741"},{"key":"e_1_2_12_5_1","doi-asserted-by":"publisher","DOI":"10.1111\/jns.12380"},{"key":"e_1_2_12_6_1","doi-asserted-by":"publisher","DOI":"10.1111\/ene.16190"},{"key":"e_1_2_12_7_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00415-009-5386-x"},{"key":"e_1_2_12_8_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00415-003-1068-2"},{"key":"e_1_2_12_9_1","doi-asserted-by":"publisher","DOI":"10.1002\/mus.26781"},{"key":"e_1_2_12_10_1","doi-asserted-by":"publisher","DOI":"10.1136\/jnnp.2005.081547"},{"key":"e_1_2_12_11_1","doi-asserted-by":"publisher","DOI":"10.1002\/mus.26611"},{"key":"e_1_2_12_12_1","doi-asserted-by":"publisher","DOI":"10.1002\/mus.27209"},{"key":"e_1_2_12_13_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1468-1331.2009.02930.x"},{"key":"e_1_2_12_14_1","doi-asserted-by":"publisher","DOI":"10.1002\/ana.25018"},{"key":"e_1_2_12_15_1","doi-asserted-by":"publisher","DOI":"10.1007\/s004150170093"}],"container-title":["Muscle &amp; Nerve"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/mus.70242","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1002\/mus.70242","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/mus.70242","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,6,20]],"date-time":"2026-06-20T05:03:13Z","timestamp":1781931793000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/mus.70242"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,4,14]]},"references-count":14,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2026,7]]}},"alternative-id":["10.1002\/mus.70242"],"URL":"https:\/\/doi.org\/10.1002\/mus.70242","archive":["Portico"],"relation":{},"ISSN":["0148-639X","1097-4598"],"issn-type":[{"value":"0148-639X","type":"print"},{"value":"1097-4598","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,4,14]]},"assertion":[{"value":"2025-04-12","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2026-04-01","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2026-04-14","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}