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In pediatric patients, early symptoms are often nonspecific, with pain, irritability, or gait refusal preceding or predominating over weakness, contributing to diagnostic delay. Although the diagnostic framework parallels that in adults, evaluation is frequently limited by challenges in examination and the need for sedation for electrodiagnostic testing or lumbar puncture. Spinal MRI with gadolinium may support the diagnosis and help exclude alternative etiologies in this setting. Treatment approaches are similar to those in adults, with intravenous immunoglobulin as first\u2010line therapy; plasma exchange is used less often due to technical constraints, and evidence guiding optimal dosing, duration, and retreatment in children remains limited. Outcomes are generally favorable, with low mortality and high rates of recovery, though early disease severity and supportive care requirements remain key prognostic factors. Acute\u2010onset chronic inflammatory demyelinating polyradiculoneuropathy represents an important diagnostic consideration, as it may initially mimic GBS and requires longitudinal follow\u2010up for distinction. Recognition of these pediatric\u2010specific features\u2014particularly atypical presentation, diagnostic limitations, and the need for ongoing reassessment\u2014is essential for timely diagnosis, appropriate management, and accurate prognostic counseling.<\/jats:p>","DOI":"10.1002\/mus.70268","type":"journal-article","created":{"date-parts":[[2026,5,13]],"date-time":"2026-05-13T06:05:00Z","timestamp":1778652300000},"page":"1328-1340","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Pediatric Guillain\u2013Barr\u00e9 Syndrome"],"prefix":"10.1002","volume":"74","author":[{"given":"Matthew","family":"Ginsberg","sequence":"first","affiliation":[{"name":"Division of Neurology Akron Children's Hospital  Akron Ohio 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