{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,20]],"date-time":"2026-06-20T05:50:36Z","timestamp":1781934636169,"version":"3.54.5"},"reference-count":29,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2026,5,11]],"date-time":"2026-05-11T00:00:00Z","timestamp":1778457600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"},{"start":{"date-parts":[[2026,5,11]],"date-time":"2026-05-11T00:00:00Z","timestamp":1778457600000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"funder":[{"DOI":"10.13039\/501100000646","name":"Japan Society for the Promotion of Science London","doi-asserted-by":"publisher","award":["25293449"],"award-info":[{"award-number":["25293449"]}],"id":[{"id":"10.13039\/501100000646","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100000646","name":"Japan Society for the Promotion of Science London","doi-asserted-by":"publisher","award":["16H05583"],"award-info":[{"award-number":["16H05583"]}],"id":[{"id":"10.13039\/501100000646","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Muscle and Nerve"],"published-print":{"date-parts":[[2026,7]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Introduction\/Aims<\/jats:title>\n                    <jats:p>Slowing of motor nerve conduction is not classically regarded as a feature of amyotrophic lateral sclerosis (ALS). We introduce a novel electrophysiological parameter, offset motor conduction velocity (offset\u2010MCV), to assess conduction in relatively slower motor axons and investigate its association with survival in ALS.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>Motor nerve conduction studies of the median and tibial nerves were performed in 145 patients with ALS and 70 healthy controls. Onset and offset latencies of compound muscle action potentials were measured, and onset\u2010 and offset\u2010MCVs were calculated. Patients were followed until death or tracheostomy, and associations between MCV parameters and survival were analyzed.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      Both onset\u2010 and offset\u2010MCVs were significantly reduced in patients with ALS compared with controls for the median and tibial nerves (all\n                      <jats:italic>p<\/jats:italic>\n                      \u2009&lt;\u20090.0001). Onset\u2010MCVs were not associated with survival. In contrast, reduced offset\u2010MCVs in both nerves were associated with short survival (log\u2010rank test: median nerve,\n                      <jats:italic>p<\/jats:italic>\n                      \u2009=\u20090.009; tibial nerve,\n                      <jats:italic>p<\/jats:italic>\n                      \u2009=\u20090.021). Multivariate Cox regression analysis identified tibial nerve offset\u2010MCV as an independent prognostic factor (\n                      <jats:italic>p<\/jats:italic>\n                      \u2009=\u20090.029).\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Discussion<\/jats:title>\n                    <jats:p>Pathological slowing of motor nerve conduction occurs in ALS and is associated with poor survival. Offset\u2010MCV may reflect disease\u2010related changes in slower \u03b1\u2010motor axons and represents a potential prognostic biomarker in ALS.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1002\/mus.70273","type":"journal-article","created":{"date-parts":[[2026,5,12]],"date-time":"2026-05-12T06:01:28Z","timestamp":1778565688000},"page":"207-215","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Offset Conduction Velocity Reveals Prognostic Slowing of\u00a0Motor Axons in Amyotrophic Lateral Sclerosis"],"prefix":"10.1002","volume":"74","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-3828-9669","authenticated-orcid":false,"given":"Toshio","family":"Shimizu","sequence":"first","affiliation":[{"name":"Department of Neurology Tokyo Metropolitan Neurological Hospital  Fuchu Tokyo Japan"},{"name":"Unit for Intractable Disease Nursing Care Tokyo Metropolitan Institute of Medical Science  Setagaya Tokyo Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hironobu","family":"Myojin","sequence":"additional","affiliation":[{"name":"Department of Neurology Tokyo Metropolitan Neurological Hospital  Fuchu Tokyo Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kota","family":"Bokuda","sequence":"additional","affiliation":[{"name":"Department of Neurology Tokyo Metropolitan Neurological Hospital  Fuchu Tokyo Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tomoya","family":"Kawazoe","sequence":"additional","affiliation":[{"name":"Department of Neurology Tokyo Metropolitan Neurological Hospital  Fuchu Tokyo Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ryo","family":"Morishima","sequence":"additional","affiliation":[{"name":"Department of Neurology Tokyo Metropolitan Neurological Hospital  Fuchu Tokyo Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hideki","family":"Kimura","sequence":"additional","affiliation":[{"name":"Department of Neurology Tokyo Metropolitan Neurological Hospital  Fuchu Tokyo Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kazushi","family":"Takahashi","sequence":"additional","affiliation":[{"name":"Department of Neurology Tokyo Metropolitan Neurological Hospital  Fuchu Tokyo Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yuki","family":"Nakayama","sequence":"additional","affiliation":[{"name":"Unit for Intractable Disease Nursing Care Tokyo Metropolitan Institute of Medical Science  Setagaya Tokyo Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2026,5,11]]},"reference":[{"key":"e_1_2_14_2_1","doi-asserted-by":"publisher","DOI":"10.1007\/s13311\u2010016\u20100492\u20109"},{"key":"e_1_2_14_3_1","doi-asserted-by":"publisher","DOI":"10.1136\/jnnp\u20102012\u2010304545"},{"key":"e_1_2_14_4_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.clinph.2013.10.052"},{"key":"e_1_2_14_5_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jns.2010.11.025"},{"key":"e_1_2_14_6_1","doi-asserted-by":"publisher","DOI":"10.1002\/mus.20475"},{"key":"e_1_2_14_7_1","doi-asserted-by":"publisher","DOI":"10.1002\/mus.21010"},{"key":"e_1_2_14_8_1","doi-asserted-by":"publisher","DOI":"10.3109\/17482968.2011.627590"},{"key":"e_1_2_14_9_1","doi-asserted-by":"publisher","DOI":"10.1136\/pn\u20102023\u2010003963"},{"key":"e_1_2_14_10_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41392\u2010023\u201001486\u20105"},{"key":"e_1_2_14_11_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.clinph.2007.09.143"},{"key":"e_1_2_14_12_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.clinph.2020.04.005"},{"key":"e_1_2_14_13_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0022\u2010510X(99)00210\u20105"},{"key":"e_1_2_14_14_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jns.2008.07.016"},{"key":"e_1_2_14_15_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00415\u2010019\u201009276\u20102"},{"key":"e_1_2_14_16_1","doi-asserted-by":"publisher","DOI":"10.1212\/WNL.0000000000005424"},{"key":"e_1_2_14_17_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.clinph.2021.05.023"},{"key":"e_1_2_14_18_1","doi-asserted-by":"publisher","DOI":"10.1213\/ANE.0000000000002864"},{"key":"e_1_2_14_19_1","doi-asserted-by":"publisher","DOI":"10.1002\/mus.880150312"},{"key":"e_1_2_14_20_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1529\u20108027.2009.00226.x"},{"key":"e_1_2_14_21_1","doi-asserted-by":"publisher","DOI":"10.1136\/jnnp\u20102011\u2010301782"},{"key":"e_1_2_14_22_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.clinph.2013.02.117"},{"key":"e_1_2_14_23_1","doi-asserted-by":"publisher","DOI":"10.1001\/jamaneurol.2022.1113"},{"key":"e_1_2_14_24_1","doi-asserted-by":"publisher","DOI":"10.1093\/brain\/awab285"},{"key":"e_1_2_14_25_1","doi-asserted-by":"publisher","DOI":"10.1002\/glia.23768"},{"key":"e_1_2_14_26_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00415\u2010020\u201009858\u20105"},{"key":"e_1_2_14_27_1","doi-asserted-by":"publisher","DOI":"10.1136\/jnnp\u20102023\u2010333039"},{"key":"e_1_2_14_28_1","doi-asserted-by":"publisher","DOI":"10.1002\/mus.26042"},{"key":"e_1_2_14_29_1","doi-asserted-by":"publisher","DOI":"10.1080\/21678421.2024.2443985"},{"key":"e_1_2_14_30_1","doi-asserted-by":"publisher","DOI":"10.1080\/21678421.2024.230998"}],"container-title":["Muscle 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