{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,11]],"date-time":"2026-09-11T22:19:36Z","timestamp":1789165176502,"version":"build-2803163510"},"reference-count":29,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2026,5,20]],"date-time":"2026-05-20T00:00:00Z","timestamp":1779235200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"},{"start":{"date-parts":[[2026,5,20]],"date-time":"2026-05-20T00:00:00Z","timestamp":1779235200000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"funder":[{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["U10CA37420"],"award-info":[{"award-number":["U10CA37420"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["K24NS126861"],"award-info":[{"award-number":["K24NS126861"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["R21 CA235389"],"award-info":[{"award-number":["R21 CA235389"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["UG1CA189961"],"award-info":[{"award-number":["UG1CA189961"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Muscle and Nerve"],"published-print":{"date-parts":[[2026,8]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Introduction\/Aims<\/jats:title>\n                    <jats:p>Chemotherapy\u2010induced peripheral neuropathy (CIPN) affects 30%\u201360% of patients who receive neurotoxic chemotherapy. Multiple studies have shown that these symptoms negatively impact patients' quality of life. This study seeks to examine the association of the severity of pain in CIPN and different health outcomes after adjustment for non\u2010painful symptoms.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>Baseline data from two randomized clinical trials (RCTs) involving 595 participants with painful and non\u2010painful CIPN were used to examine associations between pain severity and mental and physical function using linear regression models. Participants were grouped into four pain severity categories measured via the 0\u201310 numeric rating scale. The analyses were repeated with adjustment for non\u2010painful symptoms.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      The proportions of participants reporting severe pain were similar between trials (41% vs. 48%). Participants with severe CIPN pain in both trials (\n                      <jats:italic>N<\/jats:italic>\n                      \u2009=\u2009274) reported worse outcomes across all assessed domains than participants with non\u2010painful CIPN (\n                      <jats:italic>N<\/jats:italic>\n                      \u2009=\u200970) (\n                      <jats:italic>p<\/jats:italic>\n                      \u2009&lt;\u20090.02). However, this was not consistently observed when comparing to other pain groups (mild or moderate pain). When the analyses were repeated with the severity of numbness and tingling included as covariates for a proxy of overall neuropathy severity, the associations between pain and health domains were similar.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Discussion<\/jats:title>\n                    <jats:p>Participants with CIPN experiencing severe pain have worse health outcomes than participants with non\u2010painful CIPN, regardless of severity of other non\u2010painful neuropathy symptoms. Research should focus on developing effective pharmacological and non\u2010pharmacological interventions that target pain to reduce the symptom burden of CIPN and increase implementation of currently available interventions for pain in the context of CIPN.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1002\/mus.70287","type":"journal-article","created":{"date-parts":[[2026,5,21]],"date-time":"2026-05-21T03:36:02Z","timestamp":1779334562000},"page":"357-365","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Association of Pain With Mental and Physical Function in Patients With Chemotherapy\u2010Induced Peripheral Neuropathy: A Secondary Analysis From Two Randomized Controlled Trials"],"prefix":"10.1002","volume":"74","author":[{"ORCID":"https:\/\/orcid.org\/0009-0003-3678-9007","authenticated-orcid":false,"given":"Karim","family":"Saab","sequence":"first","affiliation":[{"name":"Department of Anesthesiology and Perioperative Medicine University of Rochester School of Medicine and Dentistry  Rochester New York USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Umang","family":"Gada","sequence":"additional","affiliation":[{"name":"Department of Surgery, Supportive Care in Cancer University of Rochester Medical Center  Rochester New York USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Michael B.","family":"Sohn","sequence":"additional","affiliation":[{"name":"Department of Biostatistics and Computational Biology University of Rochester  Rochester New York USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lauren","family":"Major","sequence":"additional","affiliation":[{"name":"Department of Anesthesiology and Perioperative Medicine University of Rochester School of Medicine and Dentistry  Rochester New York USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Brian","family":"Burnette","sequence":"additional","affiliation":[{"name":"Cancer Research of Wisconsin and Northern Michigan NCORP  Green Bay Wisconsin USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Melyssa","family":"Foust","sequence":"additional","affiliation":[{"name":"Upstate Carolina Consortium Community Oncology Research Program  Greer South Carolina USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dhaval","family":"Shah","sequence":"additional","affiliation":[{"name":"Helen F. Graham Cancer Center and Research Institute, Christiana Care  Newark Delaware USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Judith O.","family":"Hopkins","sequence":"additional","affiliation":[{"name":"Southeast Clinical Oncology Research Consortium NCORP\/Novant Health Cancer Institute  Winston Salem North Carolina USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gary","family":"Morrow","sequence":"additional","affiliation":[{"name":"Department of Surgery, Supportive Care in Cancer University of Rochester Medical Center  Rochester New York USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Karen","family":"Mustain","sequence":"additional","affiliation":[{"name":"Department of Surgery, Supportive Care in Cancer University of Rochester Medical Center  Rochester New York USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Supriya G.","family":"Mohile","sequence":"additional","affiliation":[{"name":"Department of Hematology and Oncology Wilmott Cancer Institute, University of Rochester Medical Center  Rochester New York USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lynn","family":"Gauthier","sequence":"additional","affiliation":[{"name":"Department of Family and Emergency Medicine Faculty of Medicine, Universit\u00e9 Laval; Oncology Division, Research Center of the Centre Hospitalier Universitaire de Qu\u00e9bec\u2010Universit\u00e9 Laval  Quebec Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6996-5068","authenticated-orcid":false,"given":"Robert","family":"Knoerl","sequence":"additional","affiliation":[{"name":"Department of Health Behavior and Clinical Science University of Michigan School of Nursing  Ann Arbor Michigan USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Susanna B.","family":"Park","sequence":"additional","affiliation":[{"name":"School of Medical Sciences, Faculty of Medicine and Health, Brain and Mind Centre, the University of Sydney  Sydney Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jennifer S.","family":"Gewandter","sequence":"additional","affiliation":[{"name":"Department of Anesthesiology and Perioperative Medicine University of Rochester School of Medicine and Dentistry  Rochester New York USA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2026,5,20]]},"reference":[{"key":"e_1_2_12_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.pain.2014.09.020"},{"key":"e_1_2_12_3_1","doi-asserted-by":"publisher","DOI":"10.3322\/caac.21204"},{"key":"e_1_2_12_4_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.diabres.2018.02.043"},{"key":"e_1_2_12_5_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00520-014-2255-7"},{"key":"e_1_2_12_6_1","doi-asserted-by":"publisher","DOI":"10.1007\/s10549-017-4230-8"},{"key":"e_1_2_12_7_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00520-013-1766-y"},{"key":"e_1_2_12_8_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00520-013-1905-5"},{"key":"e_1_2_12_9_1","doi-asserted-by":"publisher","DOI":"10.1200\/JCO.20.01399"},{"key":"e_1_2_12_10_1","doi-asserted-by":"publisher","DOI":"10.3389\/fphar.2022.1080888"},{"key":"e_1_2_12_11_1","doi-asserted-by":"publisher","DOI":"10.1007\/s11916-023-01107-4"},{"key":"e_1_2_12_12_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00520-023-08245-w"},{"key":"e_1_2_12_13_1","doi-asserted-by":"publisher","DOI":"10.6004\/jnccn.2023.7083"},{"key":"e_1_2_12_14_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jpain.2023.11.014"},{"key":"e_1_2_12_15_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00520-014-2158-7"},{"key":"e_1_2_12_16_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jpain.2015.07.002"},{"key":"e_1_2_12_17_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.clgc.2013.07.003"},{"key":"e_1_2_12_18_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ejca.2005.02.012"},{"key":"e_1_2_12_19_1","doi-asserted-by":"publisher","DOI":"10.1177\/1073191111411667"},{"key":"e_1_2_12_20_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0022-3999(01)00296-3"},{"key":"e_1_2_12_21_1","doi-asserted-by":"publisher","DOI":"10.1007\/s11136-020-02603-5"},{"key":"e_1_2_12_22_1","doi-asserted-by":"publisher","DOI":"10.1200\/JCO.2009.25.9978"},{"issue":"2","key":"e_1_2_12_23_1","first-page":"129","article-title":"Pain Assessment: Global Use of the Brief Pain Inventory","volume":"23","author":"Cleeland C. 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