{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,10]],"date-time":"2026-10-10T22:05:02Z","timestamp":1791669902931,"version":"4.3.4"},"reference-count":20,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2026,5,24]],"date-time":"2026-05-24T00:00:00Z","timestamp":1779580800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2026,5,24]],"date-time":"2026-05-24T00:00:00Z","timestamp":1779580800000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Muscle and Nerve"],"published-print":{"date-parts":[[2026,8]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Introduction\/Aim<\/jats:title>\n                    <jats:p>\n                      <jats:italic>Optimizing Management of Endocrine Complications in Duchenne Muscular Dystrophy<\/jats:italic>\n                      (OPTIMIZE DMD) is an international consortium of clinicians created to advance endocrine and bone clinical care in DMD. The aim of this study was to better understand current views and practices regarding investigation and management of growth and puberty concerns in individuals with DMD, relative to the 2018 Care Considerations and to inform updated guidance around endocrine care.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>A survey was created and sent to 47 OPTIMIZE DMD Consortium members and allied clinicians between September and November 2024. Areas surveyed included evaluation of growth, puberty, and arrested puberty\/hypogonadism, and related management including use of vamorolone, growth hormone and testosterone.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>Survey responses were received from 37 clinicians (79%). Most individuals were referred to endocrinology for growth and puberty concerns, with referral patterns contingent upon the endocrinology\/multidisciplinary clinic model. Management discussions for growth concerns involved continued monitoring (95% of clinicians), glucocorticoid adjustment (54%) including vamorolone (35%), and growth hormone (41%). For pubertal delay, 88% of endocrinologists offered testosterone for pubertal induction, most commonly intramuscular 4\u2010weekly testosterone injections. Most endocrinologists (92%) offered testosterone supplementation for arrested puberty\/hypogonadism, some (24%) on a case\u2010by\u2010case basis. Delivery routes were more varied, with subcutaneous injections prescribed by 52%.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Discussion<\/jats:title>\n                    <jats:p>Compared with the 2018 Care Considerations, monitoring practices for growth and puberty remain largely consistent, while variability persists in management approaches. These findings provide important insights to inform future guidance and identify priorities for further education and research in endocrine management for individuals with DMD.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1002\/mus.70288","type":"journal-article","created":{"date-parts":[[2026,5,25]],"date-time":"2026-05-25T03:26:47Z","timestamp":1779679607000},"page":"433-439","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["Optimizing Care for Growth and Puberty in Duchenne Muscular Dystrophy: A Survey of Clinical Practice in the\n                    <scp>OPTIMIZE DMD<\/scp>\n                    Consortium"],"prefix":"10.1002","volume":"74","author":[{"given":"Claire L.","family":"Wood","sequence":"first","affiliation":[{"name":"Department of Paediatric Endocrinology Great North Children's Hospital  Newcastle upon Tyne UK"},{"name":"Translational and Clinical Research Institute Faculty of Medical Sciences, Newcastle University  Newcastle upon Tyne UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Funmbi","family":"Babalola","sequence":"additional","affiliation":[{"name":"Department of Pediatrics, Division of Endocrinology Western University, Children's Hospital, London Health Sciences Centre  Ontario Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Robert W.","family":"Benjamin","sequence":"additional","affiliation":[{"name":"Department of Pediatrics, Division of Endocrinology Duke University Medical Center  Durham North Carolina USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Carol","family":"Lam","sequence":"additional","affiliation":[{"name":"Department of Pediatrics, University of Toronto, Canada; Division of Endocrinology Hospital for Sick Children  Toronto Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Laura","family":"McAdam","sequence":"additional","affiliation":[{"name":"Bloorview Research Institute Holland Bloorview Kids Rehabilitation Hospital  Toronto Canada"},{"name":"Department of Paediatrics, Temerty Faculty of Medicine University of Toronto  Toronto Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5631-0559","authenticated-orcid":false,"given":"Stefan","family":"Nicolau","sequence":"additional","affiliation":[{"name":"Center for Gene Therapy, Nationwide Children's Hospital, Columbus, Ohio, USA; Department of Pediatrics The Ohio State University  Columbus Ohio USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anne Marie","family":"Sbrocchi","sequence":"additional","affiliation":[{"name":"Division of Pediatrics and Metabolism Montreal Children's Hospital, McGill University Health Center  Montreal Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mena","family":"Scavina","sequence":"additional","affiliation":[{"name":"Parent Project Muscular Dystrophy  Washington D.C USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Julia C.","family":"Sorbara","sequence":"additional","affiliation":[{"name":"Department of Pediatrics, University of Toronto, Canada; Division of Endocrinology Hospital for Sick Children  Toronto Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alexandra","family":"Ahmet","sequence":"additional","affiliation":[{"name":"Division of Endocrinology, Children's Hospital of Eastern Ontario (CHEO); Department of Pediatrics University of Ottawa  Ottawa Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Susan","family":"Apkon","sequence":"additional","affiliation":[{"name":"Department of Physical Medicine and Rehabilitation Children's Hospital Colorado and University of Colorado School of Medicine  Aurora Colorado USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2933-5579","authenticated-orcid":false,"given":"Sonum","family":"Bharill","sequence":"additional","affiliation":[{"name":"Division of Endocrinology, Department of Pediatrics Johns Hopkins University School of Medicine  Baltimore Maryland USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Melissa","family":"Fiscaletti","sequence":"additional","affiliation":[{"name":"Department of Pediatrics Sainte Justine University Hospital, Universit\u00e9 de Montr\u00e9al  Montreal Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kathi","family":"Kinnett","sequence":"additional","affiliation":[{"name":"Parent Project Muscular Dystrophy  Washington D.C USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hugh J.","family":"McMillan","sequence":"additional","affiliation":[{"name":"Division of Neurology, Children's Hospital of Eastern Ontario (CHEO); Department of Pediatrics University of Ottawa  Ottawa Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nadia","family":"Merchant","sequence":"additional","affiliation":[{"name":"Division of Pediatric Endocrinology, Department of Pediatrics University of Texas Southwestern Medical Center  Dallas Texas USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nat","family":"Nasomyont","sequence":"additional","affiliation":[{"name":"Division of Diabetes and Endocrinology, Cincinnati Children's Hospital Medical Center; College of Medicine University of Cincinnati  Cincinnati Ohio USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Maria Fernanda Ochoa","family":"Molina","sequence":"additional","affiliation":[{"name":"Endocrinology Unit, Division of Pediatrics, School of Medicine Pontifical Catholic University of Chile  Santiago CL Chile"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8186-4462","authenticated-orcid":false,"given":"Nora E.","family":"Renthal","sequence":"additional","affiliation":[{"name":"Department of Pediatrics, Division of Endocrinology Boston Children's Hospital and Harvard Medical School  Boston Massachusetts USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Pamela","family":"Smith","sequence":"additional","affiliation":[{"name":"Division of Endocrinology Phoenix Children's Hospital  Phoenix Arizona USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Prasanth N.","family":"Surampudi","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine, Division of Endocrinology University of California, Davis Medical Center  Sacramento California USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3630-9937","authenticated-orcid":false,"given":"Jaclyn G.","family":"Tamaroff","sequence":"additional","affiliation":[{"name":"Division of Endocrinology and Diabetes, Department of Pediatrics Vanderbilt University Medical Center  Nashville Tennessee USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Cuixia","family":"Tian","sequence":"additional","affiliation":[{"name":"Division of Diabetes and Endocrinology, Cincinnati Children's Hospital Medical Center; College of Medicine University of Cincinnati  Cincinnati Ohio USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Leanne M.","family":"Ward","sequence":"additional","affiliation":[{"name":"Division of Endocrinology, Children's Hospital of Eastern Ontario (CHEO); Department of Pediatrics University of Ottawa  Ottawa Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6895-2372","authenticated-orcid":false,"given":"David R.","family":"Weber","sequence":"additional","affiliation":[{"name":"Division of Endocrinology and Diabetes, the Children's Hospital of Philadelphia; Department of Pediatrics University of Pennsylvania Perelman School of Medicine  Philadelphia Pennsylvania USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2845-6555","authenticated-orcid":false,"given":"Sze Choong (Jarod)","family":"Wong","sequence":"additional","affiliation":[{"name":"Department of Pediatric Endocrinology, Royal Hospital for Children; Human Nutrition, School of Medicine, Dentistry and Nursing University of Glasgow  Glasgow Scotland, UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Janet L.","family":"Crane","sequence":"additional","affiliation":[{"name":"Department of Pediatrics, Division of Endocrinology and Department of Orthopedic Surgery, Center for Musculoskeletal Research The Johns Hopkins University School of Medicine  Baltimore Maryland USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Meilan M.","family":"Rutter","sequence":"additional","affiliation":[{"name":"Division of Diabetes and Endocrinology, Cincinnati Children's Hospital Medical Center; College of Medicine University of Cincinnati  Cincinnati Ohio USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"name":"the OPTIMIZE DMD Consortium","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2026,5,24]]},"reference":[{"key":"e_1_2_13_2_1","doi-asserted-by":"publisher","DOI":"10.1097\/MED.0000000000000456"},{"issue":"1","key":"e_1_2_13_3_1","first-page":"303370","article-title":"A Parent Project Muscular Dystrophy\u2010Sponsored International Workshop Report on Endocrine and Bone Issues in Patients With Duchenne Muscular Dystrophy: An Ever\u2010Changing Landscape","volume":"12","author":"Ward L. M.","year":"2025","journal-title":"J Neuromuscul Dis"},{"key":"e_1_2_13_4_1","doi-asserted-by":"publisher","DOI":"10.1016\/S1474-4422(18)30024-3"},{"key":"e_1_2_13_5_1","doi-asserted-by":"publisher","DOI":"10.1542\/peds.2018-0333F"},{"key":"e_1_2_13_6_1","unstructured":"Jisc. 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Horm Res","volume":"93","author":"Lee S. L.\u2010K.","year":"2020","journal-title":"Paediatr"},{"key":"e_1_2_13_17_1","doi-asserted-by":"publisher","DOI":"10.1515\/jpem-2025-0061"},{"key":"e_1_2_13_18_1","doi-asserted-by":"publisher","DOI":"10.1080\/09638288.2020.1725155"},{"key":"e_1_2_13_19_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ensci.2024.100513"},{"key":"e_1_2_13_20_1","doi-asserted-by":"publisher","DOI":"10.3233\/JND-230144"},{"key":"e_1_2_13_21_1","doi-asserted-by":"publisher","DOI":"10.1515\/jpem-2025-0039"}],"container-title":["Muscle &amp; Nerve"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/mus.70288","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1002\/mus.70288","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/mus.70288","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,9,11]],"date-time":"2026-09-11T22:04:36Z","timestamp":1789164276000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/mus.70288"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,5,24]]},"references-count":20,"journal-issue":{"issue":"2","published-print":{"date-parts":[[2026,8]]}},"alternative-id":["10.1002\/mus.70288"],"URL":"https:\/\/doi.org\/10.1002\/mus.70288","archive":["Portico"],"relation":{},"ISSN":["0148-639X","1097-4598"],"issn-type":[{"value":"0148-639X","type":"print"},{"value":"1097-4598","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,5,24]]},"assertion":[{"value":"2025-09-04","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2026-05-13","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2026-05-24","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}