{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,11]],"date-time":"2026-09-11T22:19:39Z","timestamp":1789165179516,"version":"build-2803163510"},"reference-count":22,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2026,5,29]],"date-time":"2026-05-29T00:00:00Z","timestamp":1780012800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"},{"start":{"date-parts":[[2026,5,29]],"date-time":"2026-05-29T00:00:00Z","timestamp":1780012800000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Muscle and Nerve"],"published-print":{"date-parts":[[2026,8]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Introduction\/Aims<\/jats:title>\n                    <jats:p>Open muscle biopsy (OMB) is a key diagnostic tool for neuromuscular diseases, though patients often worry about risks and discomfort. This study aimed to assess pain during and after OMB, factors influencing pain perception, and adverse events.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>In this single\u2010center prospective study at the Neuropathology Unit of the Piti\u00e9\u2010Salp\u00eatri\u00e8re Hospital, Paris, 100 patients (68 women; mean age 55.4\u2009years) aged \u2265\u200918\u2009years with suspected myopathy were enrolled from August 2024 to June 2025. Exclusion criteria were inability to understand French, pregnancy, and no social security coverage. Patients completed the numerical rating scale (NRS) for pain assessment and the Patient Health Questionnaire\u20109. Descriptive statistics summarized patient characteristics. Univariate and multivariate linear regression analyses identified factors associated with procedural pain. Follow\u2010up phone calls were performed at 15 and 30\u2009days postbiopsy.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      Procedural pain was mild (median NRS\u2009=\u20092) with moderate and weak positive correlations with preprocedural anxiety (\n                      <jats:italic>r<\/jats:italic>\n                      \u2009=\u20090.54,\n                      <jats:italic>p<\/jats:italic>\n                      \u2009&lt;\u20090.01) and Clinical Frailty Scale scores (\n                      <jats:italic>r<\/jats:italic>\n                      \u2009=\u20090.32,\n                      <jats:italic>p<\/jats:italic>\n                      \u2009=\u20090.02), respectively. Weak negative correlations were observed with satisfaction with staff communication (\n                      <jats:italic>r<\/jats:italic>\n                      \u2009=\u2009\u22120.29,\n                      <jats:italic>p<\/jats:italic>\n                      \u2009=\u20090.02) and comfort with medical staff (\n                      <jats:italic>r<\/jats:italic>\n                      \u2009=\u2009\u22120.27,\n                      <jats:italic>p<\/jats:italic>\n                      \u2009=\u20090.05). Postprocedural discomfort occurred in 42\/83 patients, mostly short\u2010lived. No major complications occurred.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Discussion<\/jats:title>\n                    <jats:p>OMB is a safe procedure. Pain intensity was lower than that generally reported in the literature. Frailty may influence acute pain perception. Preprocedural anxiety emerged as the strongest predictor of pain intensity. Therefore, preprocedural anxiety should be routinely addressed in patients undergoing OMB.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1002\/mus.70293","type":"journal-article","created":{"date-parts":[[2026,5,29]],"date-time":"2026-05-29T11:57:09Z","timestamp":1780055829000},"page":"383-389","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Psychosocial Determinants of Pain in Muscle Biopsy"],"prefix":"10.1002","volume":"74","author":[{"ORCID":"https:\/\/orcid.org\/0009-0000-6385-8432","authenticated-orcid":false,"given":"Beatrice","family":"Labella","sequence":"first","affiliation":[{"name":"Neuromuscular Functional Unit, Department of Neuropathology Groupe Hospitalier Universitaire La Piti\u00e9\u2010Salp\u00eatri\u00e8re \u2010 Sorbonne University  Paris France"},{"name":"Neuromuscular Morphology Unit Myology Institute, Groupe Hospitalier Universitaire Piti\u00e9\u2010Salp\u00eatri\u00e8re  Paris France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Emmanuelle","family":"Lacene","sequence":"additional","affiliation":[{"name":"Neuromuscular Functional Unit, Department of Neuropathology Groupe Hospitalier Universitaire La Piti\u00e9\u2010Salp\u00eatri\u00e8re \u2010 Sorbonne University  Paris France"},{"name":"Neuromuscular Morphology Unit Myology Institute, Groupe Hospitalier Universitaire Piti\u00e9\u2010Salp\u00eatri\u00e8re  Paris France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Maud","family":"Beuvin","sequence":"additional","affiliation":[{"name":"Neuromuscular Morphology Unit Myology Institute, Groupe Hospitalier Universitaire Piti\u00e9\u2010Salp\u00eatri\u00e8re  Paris France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ana\u00efs","family":"Chanut","sequence":"additional","affiliation":[{"name":"Neuromuscular Morphology Unit Myology Institute, Groupe Hospitalier Universitaire Piti\u00e9\u2010Salp\u00eatri\u00e8re  Paris France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Angeline","family":"Madelaine","sequence":"additional","affiliation":[{"name":"Neuromuscular Functional Unit, Department of Neuropathology Groupe Hospitalier Universitaire La Piti\u00e9\u2010Salp\u00eatri\u00e8re \u2010 Sorbonne University  Paris France"},{"name":"Neuromuscular Morphology Unit Myology Institute, Groupe Hospitalier Universitaire Piti\u00e9\u2010Salp\u00eatri\u00e8re  Paris France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Favienne","family":"Levy\u2010Borsato","sequence":"additional","affiliation":[{"name":"Neuromuscular Morphology Unit Myology Institute, Groupe Hospitalier Universitaire Piti\u00e9\u2010Salp\u00eatri\u00e8re  Paris France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Guy","family":"Brochier","sequence":"additional","affiliation":[{"name":"Neuromuscular Functional Unit, Department of Neuropathology Groupe Hospitalier Universitaire La Piti\u00e9\u2010Salp\u00eatri\u00e8re \u2010 Sorbonne University  Paris France"},{"name":"Neuromuscular Morphology Unit Myology Institute, Groupe Hospitalier Universitaire Piti\u00e9\u2010Salp\u00eatri\u00e8re  Paris France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Cl\u00e9mence","family":"Labasse","sequence":"additional","affiliation":[{"name":"Neuromuscular Morphology Unit Myology Institute, Groupe Hospitalier Universitaire Piti\u00e9\u2010Salp\u00eatri\u00e8re  Paris France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Guillaume","family":"Bassez","sequence":"additional","affiliation":[{"name":"Department of Neuromyologie Myology Institute, Groupe Hospitalier Universitaire La Piti\u00e9\u2010Salp\u00eatri\u00e8re  Paris France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Danielle","family":"Seilhean","sequence":"additional","affiliation":[{"name":"Neuromuscular Functional Unit, 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