{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,11]],"date-time":"2026-09-11T22:19:40Z","timestamp":1789165180447,"version":"build-2803163510"},"reference-count":24,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2026,6,6]],"date-time":"2026-06-06T00:00:00Z","timestamp":1780704000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"},{"start":{"date-parts":[[2026,6,6]],"date-time":"2026-06-06T00:00:00Z","timestamp":1780704000000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"funder":[{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["CA188654"],"award-info":[{"award-number":["CA188654"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["AR040864"],"award-info":[{"award-number":["AR040864"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100005202","name":"Muscular Dystrophy Association","doi-asserted-by":"publisher","award":["312455"],"award-info":[{"award-number":["312455"]}],"id":[{"id":"10.13039\/100005202","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Muscle and Nerve"],"published-print":{"date-parts":[[2026,8]]},"abstract":"ABSTRACT<\/jats:title>\n \n Introduction\/Aims<\/jats:title>\n Although magnetic resonance imaging (MRI) has been extensively applied in dystrophic muscle, longitudinal characterization of multiple quantitative MRI parameters during degeneration and regeneration remains limited. This study aimed to longitudinally characterize changes in quantitative MRI parameters in control and dystrophic mouse muscles following myotoxin\u2010induced myonecrosis using multi\u2010parametric MRI (mpMRI).<\/jats:p>\n <\/jats:sec>\n \n Methods<\/jats:title>\n \n mpMRI was performed at 14 Tesla in\n mdx<\/jats:italic>\n \n 4cv<\/jats:italic>\n <\/jats:sup>\n mice (\n n<\/jats:italic>\n \u2009=\u200910) and control (ctrl) mice (\n n<\/jats:italic>\n \u2009=\u20095) following intramuscular BaCl\n 2<\/jats:sub>\n injection. Quantitative maps of T1, T2, magnetization transfer ratio (MTR), and diffusion metrics were obtained from myotoxin\u2010 and saline\u2010injected hind\u2010limb muscles at multiple time points.\n <\/jats:p>\n <\/jats:sec>\n \n Results<\/jats:title>\n \n Mean T1 values decreased, reaching minima at day 5 in ctrl (3.05\u2009\u00b1\u20090.67\u2009s) and day 3 in\n mdx<\/jats:italic>\n \n 4cv<\/jats:italic>\n <\/jats:sup>\n (2.60\u2009\u00b1\u20090.28\u2009s) muscles. Mean T2 values increased and peaked at day 3 in both ctrl (34.83\u2009\u00b1\u20094.73\u2009ms) and\n mdx<\/jats:italic>\n \n 4cv<\/jats:italic>\n <\/jats:sup>\n (33.53\u2009\u00b1\u20092.98\u2009ms) muscles. MTR values decreased, reaching lowest levels at day 5 post\u2010injection in both ctrl (69.12%\u2009\u00b1\u20096.23%) and\n mdx<\/jats:italic>\n \n 4cv<\/jats:italic>\n <\/jats:sup>\n (69.20%\u2009\u00b1\u20095.83%) muscles. T1, T2, and MTR returned to near\u2010baseline values by day 21\u2009day. Diffusion metrics demonstrated early increases in mean and radial diffusivity with a concomitant decrease in fractional anisotropy, followed by recovery between days 5 and 7.\n <\/jats:p>\n <\/jats:sec>\n \n Discussion<\/jats:title>\n mpMRI revealed distinct, time\u2010dependent changes following myotoxin injury, demonstrating the added value of mpMRI as a noninvasive approach for sensitively characterizing the temporal evolution of quantitative MRI parameters following myotoxin\u2010induced muscle injury in both control and dystrophic mice.<\/jats:p>\n <\/jats:sec>","DOI":"10.1002\/mus.70297","type":"journal-article","created":{"date-parts":[[2026,6,6]],"date-time":"2026-06-06T12:24:03Z","timestamp":1780748643000},"page":"485-491","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Quantitative\n MRI<\/scp>\n Assessment of Myotoxin\u2010Induced Skeletal Muscle Damage of\n mdx<\/i>\n Mice"],"prefix":"10.1002","volume":"74","author":[{"given":"Ravneet","family":"Vohra","sequence":"first","affiliation":[{"name":"Department of Radiology University of Washington Seattle WA USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Joshua","family":"Park","sequence":"additional","affiliation":[{"name":"Department of Radiology University of Washington Seattle WA USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Feng","family":"Zhang","sequence":"additional","affiliation":[{"name":"Department of Radiology University of Washington Seattle WA USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5299-0059","authenticated-orcid":false,"given":"Jeffrey S.","family":"Chamberlain","sequence":"additional","affiliation":[{"name":"Department of Neurology University of Washington Seattle WA USA"},{"name":"Senator Paul D. Wellstone Muscular Dystrophy Cooperative Research Center University of Washington Seattle WA USA"},{"name":"Department of Biochemistry University of Washington Seattle WA USA"},{"name":"Department of Medicine University of Washington Seattle WA USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5220-3991","authenticated-orcid":false,"given":"Donghoon","family":"Lee","sequence":"additional","affiliation":[{"name":"Department of Radiology University of Washington Seattle WA USA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2026,6,6]]},"reference":[{"key":"e_1_2_12_2_1","doi-asserted-by":"publisher","DOI":"10.1002\/ana.23528"},{"key":"e_1_2_12_3_1","doi-asserted-by":"publisher","DOI":"10.1002\/mus.20398"},{"key":"e_1_2_12_4_1","doi-asserted-by":"publisher","DOI":"10.1002\/mus.21986"},{"key":"e_1_2_12_5_1","doi-asserted-by":"publisher","DOI":"10.1002\/nbm.3113"},{"key":"e_1_2_12_6_1","doi-asserted-by":"publisher","DOI":"10.1002\/jmri.24417"},{"key":"e_1_2_12_7_1","doi-asserted-by":"publisher","DOI":"10.1002\/mrm.1910330207"},{"key":"e_1_2_12_8_1","doi-asserted-by":"publisher","DOI":"10.1002\/nbm.2851"},{"key":"e_1_2_12_9_1","doi-asserted-by":"publisher","DOI":"10.1002\/mus.24675"},{"key":"e_1_2_12_10_1","doi-asserted-by":"publisher","DOI":"10.1002\/nbm.5278"},{"key":"e_1_2_12_11_1","doi-asserted-by":"publisher","DOI":"10.3389\/fneur.2021.636719"},{"key":"e_1_2_12_12_1","doi-asserted-by":"publisher","DOI":"10.1002\/(SICI)1522-2594(199907)42:1<150::AID-MRM20>3.0.CO;2-5"},{"key":"e_1_2_12_13_1","doi-asserted-by":"publisher","DOI":"10.1097\/00004728-199907000-00023"},{"key":"e_1_2_12_14_1","doi-asserted-by":"publisher","DOI":"10.1002\/nbm.1226"},{"key":"e_1_2_12_15_1","doi-asserted-by":"publisher","DOI":"10.1002\/mrm.20953"},{"key":"e_1_2_12_16_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0124914"},{"key":"e_1_2_12_17_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0206323"},{"key":"e_1_2_12_18_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41598-019-43398-x"},{"key":"e_1_2_12_19_1","doi-asserted-by":"publisher","DOI":"10.1186\/s13395-019-0213-2"},{"key":"e_1_2_12_20_1","doi-asserted-by":"publisher","DOI":"10.1186\/s12891-025-09207-5"},{"key":"e_1_2_12_21_1","doi-asserted-by":"publisher","DOI":"10.1148\/radiol.2432060491"},{"key":"e_1_2_12_22_1","doi-asserted-by":"publisher","DOI":"10.2174\/157340507781386988"},{"key":"e_1_2_12_23_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0059308"},{"key":"e_1_2_12_24_1","doi-asserted-by":"publisher","DOI":"10.1002\/jmri.20651"},{"key":"e_1_2_12_25_1","doi-asserted-by":"publisher","DOI":"10.1002\/nbm.3909"}],"container-title":["Muscle & Nerve"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/mus.70297","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1002\/mus.70297","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/mus.70297","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,9,11]],"date-time":"2026-09-11T22:05:03Z","timestamp":1789164303000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/mus.70297"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,6,6]]},"references-count":24,"journal-issue":{"issue":"2","published-print":{"date-parts":[[2026,8]]}},"alternative-id":["10.1002\/mus.70297"],"URL":"https:\/\/doi.org\/10.1002\/mus.70297","archive":["Portico"],"relation":{},"ISSN":["0148-639X","1097-4598"],"issn-type":[{"value":"0148-639X","type":"print"},{"value":"1097-4598","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,6,6]]},"assertion":[{"value":"2025-03-09","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2026-05-18","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2026-06-06","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}