{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,11]],"date-time":"2026-09-11T22:19:36Z","timestamp":1789165176874,"version":"build-2803163510"},"reference-count":23,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2026,6,1]],"date-time":"2026-06-01T00:00:00Z","timestamp":1780272000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"},{"start":{"date-parts":[[2026,6,1]],"date-time":"2026-06-01T00:00:00Z","timestamp":1780272000000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Muscle and Nerve"],"published-print":{"date-parts":[[2026,8]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Introduction\/Aims<\/jats:title>\n                    <jats:p>Immune\u2010mediated necrotizing myopathy (IMNM) is an autoimmune myositis which is characterized by severe muscle fiber necrosis and refractoriness to immunotherapies. Overlap between myositis and other autoimmune disorders is well\u2010recognized; however, the coexistence of IMNM and Sj\u00f6gren disease (SjD) is rare. We investigated the clinicopathological features of anti\u2010signal recognition particle antibody\u2010positive IMNM associated with SjD.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>\n                      We retrospectively reviewed previously reported cases and analyzed the clinical and pathological features of two patients: a 68\u2010year\u2010old man with a 2\u2010year history of sicca symptoms, who presented a 3\u2010month history of dysphagia, difficulty arising from a sitting position and gait disturbance, and a 67\u2010year\u2010old woman with a 20\u2010year history of sicca symptoms, who subsequently developed muscle weakness, dysphagia, and\n                      <jats:styled-content style=\"fixed-case\">hyperCKemia<\/jats:styled-content>\n                      .\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>Muscle pathological findings in both patients were consistent with those of IMNM without SjD. In contrast, they exhibited relatively mild limb weakness and showed a better response to immunotherapies compared with patients with typical IMNM. Notably, Patient 1 developed severe Raynaud's phenomenon and digital ulcers, requiring additional treatment.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Discussion<\/jats:title>\n                    <jats:p>IMNM associated with SjD may present with relatively mild muscle involvement compared with IMNM without SjD; however, SjD\u2010related disease activity may become more prominent during the clinical course.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1002\/mus.70304","type":"journal-article","created":{"date-parts":[[2026,6,2]],"date-time":"2026-06-02T03:35:54Z","timestamp":1780371354000},"page":"450-456","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["A Rare Association of Anti\u2010\n                    <scp>SRP<\/scp>\n                    Antibody\u2010Positive Immune\u2010Mediated Necrotizing Myopathy and Sj\u00f6gren Disease: Two Case Reports"],"prefix":"10.1002","volume":"74","author":[{"given":"Hiroaki","family":"Tanaka","sequence":"first","affiliation":[{"name":"Department of Neurology Nara Medical University  Kashihara Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0003-4418-4462","authenticated-orcid":false,"given":"Yukako","family":"Nishimori","sequence":"additional","affiliation":[{"name":"Department of Neurology Nara Medical University  Kashihara Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4943-3152","authenticated-orcid":false,"given":"Nobuyuki","family":"Eura","sequence":"additional","affiliation":[{"name":"Department of Neurology Nara Medical University  Kashihara Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mayu","family":"Sugata","sequence":"additional","affiliation":[{"name":"Department of Neurology Nara Medical University  Kashihara Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Katsuya","family":"Takeuchi","sequence":"additional","affiliation":[{"name":"Department of Neurology Nara Medical University  Kashihara Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Masaki","family":"Kobayashi","sequence":"additional","affiliation":[{"name":"Department of Neurology Nara Medical University  Kashihara Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0148-4687","authenticated-orcid":false,"given":"Kazuma","family":"Sugie","sequence":"additional","affiliation":[{"name":"Department of Neurology Nara Medical University  Kashihara Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2026,6,1]]},"reference":[{"key":"e_1_2_11_2_1","doi-asserted-by":"publisher","DOI":"10.1111\/bpa.12772"},{"key":"e_1_2_11_3_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00296-010-1517-z"},{"key":"e_1_2_11_4_1","doi-asserted-by":"publisher","DOI":"10.1177\/0961203312474703"},{"key":"e_1_2_11_5_1","doi-asserted-by":"publisher","DOI":"10.2340\/00015555-1744"},{"key":"e_1_2_11_6_1","doi-asserted-by":"publisher","DOI":"10.1111\/1346-8138.13344"},{"key":"e_1_2_11_7_1","doi-asserted-by":"publisher","DOI":"10.5606\/ArchRheumatol.2016.5740"},{"key":"e_1_2_11_8_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.nmd.2016.08.013"},{"key":"e_1_2_11_9_1","doi-asserted-by":"publisher","DOI":"10.5692\/clinicalneurol.cn-001075"},{"key":"e_1_2_11_10_1","doi-asserted-by":"publisher","DOI":"10.31138\/mjr.29.2.92"},{"key":"e_1_2_11_11_1","doi-asserted-by":"publisher","DOI":"10.2169\/internalmedicine.9307-17"},{"issue":"2","key":"e_1_2_11_12_1","first-page":"183","article-title":"A Case of Immune\u2010Mediated Necrotizing Myopathy Associated With Primary Sj\u00f6gren Syndrome","volume":"73","author":"Takahashi N.","year":"2021","journal-title":"Brain and Nerve"},{"key":"e_1_2_11_13_1","doi-asserted-by":"publisher","DOI":"10.1186\/s12891-023-06354-5"},{"key":"e_1_2_11_14_1","doi-asserted-by":"publisher","DOI":"10.1080\/03009742.2023.2202510"},{"issue":"3","key":"e_1_2_11_15_1","first-page":"73","article-title":"A Case of Anti\u2010SRP Antibody\u2010Positive Immune\u2010Mediated Necrotizing Myopathy With Nailfold Hemorrhages and Sj\u00f6gren's Syndrome","volume":"46","author":"Kanamori M.","year":"2023","journal-title":"Toyama\u2010Kenritsu Chuo Byoin Igaku Zasshi"},{"issue":"9","key":"e_1_2_11_16_1","article-title":"Overlap of Sj\u00f6gren's Syndrome and Immune\u2010Mediated Necrotizing Myopathy With Interstitial Lung Disease: A Case Report","volume":"16","author":"Tanimura K.","year":"2024","journal-title":"Cureus"},{"key":"e_1_2_11_17_1","doi-asserted-by":"publisher","DOI":"10.1093\/rheumatology\/keae129"},{"key":"e_1_2_11_18_1","doi-asserted-by":"publisher","DOI":"10.3389\/fimmu.2025.1654576"},{"key":"e_1_2_11_19_1","doi-asserted-by":"publisher","DOI":"10.1212\/WNL.61.3.316"},{"key":"e_1_2_11_20_1","doi-asserted-by":"publisher","DOI":"10.1136\/jnnp-2016-313166"},{"key":"e_1_2_11_21_1","doi-asserted-by":"publisher","DOI":"10.1007\/s10067-021-05749-w"},{"key":"e_1_2_11_22_1","doi-asserted-by":"publisher","DOI":"10.1002\/j.2040-4603.2014.tb00541.x"},{"issue":"1","key":"e_1_2_11_23_1","article-title":"Raynaud's Phenomenon: Reviewing the Pathophysiology and Management Strategies","volume":"14","author":"Nawaz I.","year":"2022","journal-title":"Cureus"},{"key":"e_1_2_11_24_1","doi-asserted-by":"publisher","DOI":"10.1002\/ccr3.8990"}],"container-title":["Muscle &amp; 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