{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,13]],"date-time":"2026-08-13T14:42:35Z","timestamp":1786632155480,"version":"build-2736575974"},"reference-count":25,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2026,6,18]],"date-time":"2026-06-18T00:00:00Z","timestamp":1781740800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"},{"start":{"date-parts":[[2026,6,18]],"date-time":"2026-06-18T00:00:00Z","timestamp":1781740800000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"funder":[{"DOI":"10.13039\/100011724","name":"Muscular Dystrophy UK","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100011724","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100012317","name":"UCLH Biomedical Research Centre","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100012317","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Muscle and Nerve"],"published-print":{"date-parts":[[2026,9]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Introduction\/Aims<\/jats:title>\n                    <jats:p>Corticosteroids (CS) are routinely prescribed for children with Duchenne muscular dystrophy (DMD) to delay disease progression. However, evidence supporting their use beyond adolescence into adulthood is limited, resulting in inconsistent clinical practice. The aim of this study was to assess the effect of continuing CS on respiratory function in males with DMD age \u2265\u200916\u2009years and to understand the impact of CS discontinuation.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>This was a multicenter, retrospective cohort study. Pulmonary function data from medical records of 208 males, stratified into three groups (CS\u2010continued, CS\u2010stopped, CS\u2010na\u00efve) was assessed.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      Data was available for 208 subjects (age 16y\u201340.5\u2009years). Continued CS use was associated with delayed respiratory decline compared with CS\u2010stopped or CS\u2010naive, demonstrated by later attainment of key pulmonary milestones (forced vital capacity (FVC) &lt;\u20091\u2009L (24.75\u2009years vs. 19.25\u2009years vs. 20.5\u2009years;\n                      <jats:italic>p<\/jats:italic>\n                      \u2009&lt;\u20090.0001), FVC percent predicted &lt;\u200950% (17.5\u2009years vs. 16.25\u2009years vs. 16.75\u2009years;\n                      <jats:italic>p<\/jats:italic>\n                      \u2009=\u20090.0031) and &lt;\u200930% (22.79\u2009years vs. 17.04\u2009years vs. 18.38\u2009years;\n                      <jats:italic>p<\/jats:italic>\n                      \u2009&lt;\u20090.0001)) and initiation of noninvasive ventilation (NIV) (median age 19.17\u2009years vs. 16\u2009years vs. 17.33\u2009years;\n                      <jats:italic>p<\/jats:italic>\n                      \u2009=\u20090.0031). Longitudinal measures of lung function declined fastest in the CS\u2010stopped group (\n                      <jats:italic>p<\/jats:italic>\n                      \u2009&lt;\u20090.05).\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Discussion<\/jats:title>\n                    <jats:p>Continuing CS therapy into late adolescence and adulthood slows respiratory decline in DMD, even at doses below recommended levels. The most rapid rate of decline appeared in the CS\u2010stopped group. Clinically, these findings support long\u2010term CS continuation in DMD to preserve pulmonary function and delay the onset of NIV. However, the balance of benefits versus side effects of long\u2010term CS and optimal CS dose in adults remains unclear.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1002\/mus.70312","type":"journal-article","created":{"date-parts":[[2026,6,19]],"date-time":"2026-06-19T03:55:05Z","timestamp":1781841305000},"page":"570-579","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["The Effect of Corticosteroids on Pulmonary Function in a Large Cohort of Late Adolescents and Adults With Duchenne Muscular Dystrophy"],"prefix":"10.1002","volume":"74","author":[{"given":"Aleksandra","family":"Pietrusz","sequence":"first","affiliation":[{"name":"UCL Queen Square Institute of Neurology Department of Neuromuscular Diseases  London UK"},{"name":"National Hospital for Neurology and Neurosurgery  London 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