{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,11]],"date-time":"2026-09-11T22:19:36Z","timestamp":1789165176134,"version":"build-2803163510"},"reference-count":29,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2026,6,16]],"date-time":"2026-06-16T00:00:00Z","timestamp":1781568000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"},{"start":{"date-parts":[[2026,6,16]],"date-time":"2026-06-16T00:00:00Z","timestamp":1781568000000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Muscle and Nerve"],"published-print":{"date-parts":[[2026,8]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:p>\n                    There is currently no consensus on how to define recovery for individuals with amyotrophic lateral sclerosis (ALS). Tofersen treatment for superoxide dismutase\u20101\u2010related (\n                    <jats:italic>SOD1<\/jats:italic>\n                    ) ALS marks a pivot in clinical management: for the first time, clinicians can target disease stabilization and functional recovery in some individuals. This advancement shifts the focus of ALS care toward optimizing functional recovery alongside symptomatic management. However, there are no evidence\u2010based guidelines for prescribing neuromuscular rehabilitation (NMR) to improve functional recovery. Building on our preliminary single\u2010center data of integrated NMR with tofersen, we propose a new ALS Recovery Model System of Care, utilizing a hub\u2010and\u2010spoke infrastructure to combine NMR with novel therapies. This model aims to define ALS recovery, characterize recovery profiles, standardize NMR protocols, and establish a rehabilitation framework adaptable to future disease\u2010stabilizing therapies.\n                  <\/jats:p>","DOI":"10.1002\/mus.70320","type":"journal-article","created":{"date-parts":[[2026,6,17]],"date-time":"2026-06-17T06:22:02Z","timestamp":1781677322000},"page":"321-327","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["Amyotrophic Lateral Sclerosis Recovery: A New Model System of Care Integrating Neuromuscular Rehabilitation With Clinical Stabilization in\n                    <scp>ALS<\/scp>"],"prefix":"10.1002","volume":"74","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-1488-7621","authenticated-orcid":false,"given":"Sean E.","family":"Smith","sequence":"first","affiliation":[{"name":"Department of Neurology Washington University School of Medicine in St. Louis  St. Louis Missouri USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Beth","family":"Hughes","sequence":"additional","affiliation":[{"name":"Program in Physical Therapy Washington University School of Medicine in St. Louis  St. Louis Missouri USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Timothy M.","family":"Miller","sequence":"additional","affiliation":[{"name":"Department of Neurology Washington University School of Medicine in St. Louis  St. Louis Missouri USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Robert C.","family":"Bucelli","sequence":"additional","affiliation":[{"name":"Department of Neurology Washington University School of Medicine in St. Louis  St. Louis Missouri USA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2026,6,16]]},"reference":[{"key":"e_1_2_13_2_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa2204705"},{"key":"e_1_2_13_3_1","doi-asserted-by":"publisher","DOI":"10.1001\/jamaneurol.2025.4946"},{"key":"e_1_2_13_4_1","doi-asserted-by":"publisher","DOI":"10.1002\/mus.27818"},{"key":"e_1_2_13_5_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.eclinm.2024.102495"},{"key":"e_1_2_13_6_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00415-024-12437-7"},{"key":"e_1_2_13_7_1","doi-asserted-by":"publisher","DOI":"10.1038\/s43856-024-00573-0"},{"key":"e_1_2_13_8_1","doi-asserted-by":"publisher","DOI":"10.1002\/acn3.52264"},{"key":"e_1_2_13_9_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00415-025-13579-y"},{"key":"e_1_2_13_10_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.apmr.2016.02.027"},{"key":"e_1_2_13_11_1","doi-asserted-by":"publisher","DOI":"10.1089\/neur.2020.0047"},{"key":"e_1_2_13_12_1","doi-asserted-by":"publisher","DOI":"10.1002\/mus.24202"},{"key":"e_1_2_13_13_1","doi-asserted-by":"publisher","DOI":"10.1097\/PHM.0000000000001419"},{"key":"e_1_2_13_14_1","doi-asserted-by":"publisher","DOI":"10.3390\/jcm14238590"},{"key":"e_1_2_13_15_1","first-page":"1","article-title":"Therapeutic Exercise for People With Amyotrophic Lateral Sclerosis or Motor Neuron Disease","volume":"5","author":"Dal Bello\u2010Haas V.","year":"2013","journal-title":"Cochrane Database of Systematic Reviews"},{"key":"e_1_2_13_16_1","doi-asserted-by":"publisher","DOI":"10.2147\/DNND.S146949"},{"key":"e_1_2_13_17_1","doi-asserted-by":"publisher","DOI":"10.1080\/21678421.2017.1404108"},{"issue":"1","key":"e_1_2_13_18_1","first-page":"54","article-title":"Neuromuscular Notes: Exercise and Rehabilitation Medicine in Neuromuscular Disease","volume":"23","author":"Meserve C. D.","year":"2024","journal-title":"Practical Neurology"},{"key":"e_1_2_13_19_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0320788"},{"key":"e_1_2_13_20_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.apmr.2004.01.040"},{"key":"e_1_2_13_21_1","doi-asserted-by":"publisher","DOI":"10.1080\/14660820600640620"},{"key":"e_1_2_13_22_1","doi-asserted-by":"publisher","DOI":"10.3109\/17482961003792958"},{"key":"e_1_2_13_23_1","doi-asserted-by":"publisher","DOI":"10.1002\/mus.24153"},{"key":"e_1_2_13_24_1","doi-asserted-by":"publisher","DOI":"10.1080\/09638288.2019.1682066"},{"key":"e_1_2_13_25_1","doi-asserted-by":"publisher","DOI":"10.23736\/S1973-9087.24.08095-X"},{"key":"e_1_2_13_26_1","first-page":"S1","article-title":"Preliminary Outcomes of Early Neuromuscular Rehabilitation in SOD1 ALS Patients Receiving Tofersen: A 6\u2010Month Observational Study","volume":"72","author":"Smith S. E.","year":"2025","journal-title":"Proceedings of the 24th Annual NEALS Meeting. 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