{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,13]],"date-time":"2026-08-13T14:42:09Z","timestamp":1786632129468,"version":"build-2736575974"},"reference-count":22,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2026,6,28]],"date-time":"2026-06-28T00:00:00Z","timestamp":1782604800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"},{"start":{"date-parts":[[2026,6,28]],"date-time":"2026-06-28T00:00:00Z","timestamp":1782604800000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"funder":[{"DOI":"10.13039\/100005202","name":"Muscular Dystrophy Association","doi-asserted-by":"publisher","award":["MDA 1313867"],"award-info":[{"award-number":["MDA 1313867"]}],"id":[{"id":"10.13039\/100005202","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000971","name":"ALS Association","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100000971","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Muscle and Nerve"],"published-print":{"date-parts":[[2026,9]]},"abstract":"ABSTRACT<\/jats:title>\n \n Introduction\/Aims<\/jats:title>\n Respiratory weakness, typically monitored as vital capacity (VC), is a central feature of amyotrophic lateral sclerosis (ALS). VC is increasingly measured remotely in participants' homes, although in\u2010clinic assessment remains the standard. We tested concordance between at\u2010home and in\u2010clinic VC to determine trial eligibility, track progression, and predict survival in a large ALS trial.<\/jats:p>\n <\/jats:sec>\n \n Methods<\/jats:title>\n \n At\u2010home and in\u2010clinic\n VC<\/jats:styled-content>\n were assessed at baseline and approximately every 8\u2009weeks for a year in the first four regimens of the\n HEALEY ALS<\/jats:styled-content>\n Platform Trial. At\u2010home assessments were coached via live videoconference and centrally reviewed.\n VC<\/jats:styled-content>\n measurements, expressed as percent of predicted normal (%\n PN<\/jats:styled-content>\n ), were compared cross\u2010sectionally, longitudinally, and for predicting survival time. Data from 233 participants with 3\u20138 paired at\u2010home and in\u2010clinic\n VC<\/jats:styled-content>\n assessments completed <\u200914\u2009days apart were analyzed.\n <\/jats:p>\n <\/jats:sec>\n \n Results<\/jats:title>\n \n At\u2010home and in\u2010clinic\n VC<\/jats:styled-content>\n were well correlated (Lin's\n r<\/jats:italic>\n \n c<\/jats:italic>\n <\/jats:sub>\n \u2009=\u20090.82) with no systematic bias. At\u2010home\n VC<\/jats:styled-content>\n \u2265\u200960%\n PN<\/jats:styled-content>\n predicted in\u2010clinic\n VC<\/jats:styled-content>\n \u2265\u200960%\n PN<\/jats:styled-content>\n with a positive predictive value of 91% and a negative predictive value of 65%.\n VC<\/jats:styled-content>\n slopes were moderately correlated (\n r<\/jats:italic>\n \n c<\/jats:italic>\n <\/jats:sub>\n \u2009=\u20090.68). At\u2010home\n VC<\/jats:styled-content>\n progressed 28% faster than in\u2010clinic\n VC<\/jats:styled-content>\n with proportionately less variance (at\u2010home [\n SE<\/jats:styled-content>\n ]\u2009=\u2009\u22121.882 [0.153] %\n PN<\/jats:styled-content>\n \/month, in\u2010clinic\u2009=\u2009\u22121.476 [0.131] %\n PN<\/jats:styled-content>\n \/month). Slopes of at\u2010home and in\u2010clinic\n VC<\/jats:styled-content>\n explained 15% and 17% of variation in future survival time, respectively.\n <\/jats:p>\n <\/jats:sec>\n \n Discussion<\/jats:title>\n \n At\u2010home and in\u2010clinic\n VC<\/jats:styled-content>\n were well correlated cross\u2010sectionally. At\u2010home\n VC<\/jats:styled-content>\n performed well tracking longitudinal change and predicting survival. The reduced participant burden of assessment and concordance with in\u2010clinic measurement support use of at\u2010home monitoring of\n VC.<\/jats:styled-content>\n <\/jats:p>\n <\/jats:sec>","DOI":"10.1002\/mus.70322","type":"journal-article","created":{"date-parts":[[2026,6,29]],"date-time":"2026-06-29T05:13:10Z","timestamp":1782709990000},"page":"702-708","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["At\u2010Home Versus in\u2010Clinic Vital Capacity Measurement: Insights From the\n HEALEY ALS<\/scp>\n Platform Trial"],"prefix":"10.1002","volume":"74","author":[{"given":"Eric A.","family":"Macklin","sequence":"first","affiliation":[{"name":"Sean M. Healey and AMG Center for ALS & the Neurological Clinical Research Institute, Massachusetts General Hospital Boston Massachusetts USA"},{"name":"Department of Neurology Harvard Medical School Boston Massachusetts USA"},{"name":"Massachusetts General Hospital Biostatistics, Massachusetts General Hospital Boston Massachusetts USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"James D.","family":"Berry","sequence":"additional","affiliation":[{"name":"Sean M. Healey and AMG Center for ALS & the Neurological Clinical Research Institute, Massachusetts General Hospital Boston Massachusetts USA"},{"name":"Department of Neurology Harvard Medical School Boston Massachusetts USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Brittney A.","family":"Harkey","sequence":"additional","affiliation":[{"name":"Sean M. Healey and AMG Center for ALS & the Neurological Clinical Research Institute, Massachusetts General Hospital Boston Massachusetts USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lindsay","family":"Heyd","sequence":"additional","affiliation":[{"name":"Sean M. Healey and AMG Center for ALS & the Neurological Clinical Research Institute, Massachusetts General Hospital Boston Massachusetts USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marianne","family":"Chase","sequence":"additional","affiliation":[{"name":"Sean M. Healey and AMG Center for ALS & the Neurological Clinical Research Institute, Massachusetts General Hospital Boston Massachusetts USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hong","family":"Yu","sequence":"additional","affiliation":[{"name":"Sean M. Healey and AMG Center for ALS & the Neurological Clinical Research Institute, Massachusetts General Hospital Boston Massachusetts USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alexander V.","family":"Sherman","sequence":"additional","affiliation":[{"name":"Sean M. Healey and AMG Center for ALS & the Neurological Clinical Research Institute, Massachusetts General Hospital Boston Massachusetts USA"},{"name":"Department of Neurology Harvard Medical School Boston Massachusetts USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Derek","family":"Dagostino","sequence":"additional","affiliation":[{"name":"Sean M. Healey and AMG Center for ALS & the Neurological Clinical Research Institute, Massachusetts General Hospital Boston Massachusetts USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gale","family":"Kittle","sequence":"additional","affiliation":[{"name":"Barrow Neurological Institute Phoenix Arizona USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Meghan","family":"Hall","sequence":"additional","affiliation":[{"name":"Barrow Neurological Institute Phoenix Arizona USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mariah R.","family":"Connolly","sequence":"additional","affiliation":[{"name":"Barrow Neurological Institute Phoenix Arizona USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kristin","family":"Drake","sequence":"additional","affiliation":[{"name":"Sean M. Healey and AMG Center for ALS & the Neurological Clinical Research Institute, Massachusetts General Hospital Boston Massachusetts USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Elisa","family":"Giacomelli","sequence":"additional","affiliation":[{"name":"Sean M. Healey and AMG Center for ALS & the Neurological Clinical Research Institute, Massachusetts General Hospital Boston Massachusetts USA"},{"name":"Department of Neurology Harvard Medical School Boston Massachusetts USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0002-9427-1452","authenticated-orcid":false,"given":"Erica","family":"Scirocco","sequence":"additional","affiliation":[{"name":"Sean M. Healey and AMG Center for ALS & the Neurological Clinical Research Institute, Massachusetts General Hospital Boston Massachusetts USA"},{"name":"Department of Neurology Harvard Medical School Boston Massachusetts USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Saloni","family":"Sharma","sequence":"additional","affiliation":[{"name":"Sean M. Healey and AMG Center for ALS & the Neurological Clinical Research Institute, Massachusetts General Hospital Boston Massachusetts USA"},{"name":"Department of Neurology Harvard Medical School Boston Massachusetts USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Suma","family":"Babu","sequence":"additional","affiliation":[{"name":"Sean M. Healey and AMG Center for ALS & the Neurological Clinical Research Institute, Massachusetts General Hospital Boston Massachusetts USA"},{"name":"Department of Neurology Harvard Medical School Boston Massachusetts USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Michael","family":"Benatar","sequence":"additional","affiliation":[{"name":"Department of Neurology and the ALS Center Miller School of Medicine, University of Miami Miami Florida USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8574-5332","authenticated-orcid":false,"given":"Zachary","family":"Simmons","sequence":"additional","affiliation":[{"name":"Penn State Health Milton S. Hershey Medical Center Hershey Pennsylvania USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Eufrosina","family":"Young","sequence":"additional","affiliation":[{"name":"Upstate Medical University Syracuse New York USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Merit E.","family":"Cudkowicz","sequence":"additional","affiliation":[{"name":"Sean M. Healey and AMG Center for ALS & the Neurological Clinical Research Institute, Massachusetts General Hospital Boston Massachusetts USA"},{"name":"Department of Neurology Harvard Medical School Boston Massachusetts USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jeremy","family":"Shefner","sequence":"additional","affiliation":[{"name":"Barrow Neurological Institute Phoenix Arizona USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0505-1168","authenticated-orcid":false,"given":"Sabrina","family":"Paganoni","sequence":"additional","affiliation":[{"name":"Sean M. Healey and AMG Center for ALS & the Neurological Clinical Research Institute, Massachusetts General Hospital Boston Massachusetts USA"},{"name":"Department of Neurology Harvard Medical School Boston Massachusetts USA"},{"name":"Spaulding Rehabilitation Hospital, Harvard Medical School Boston Massachusetts USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"name":"the HEALEY ALS Platform Trial Study Group","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2026,6,28]]},"reference":[{"key":"e_1_2_12_2_1","doi-asserted-by":"publisher","DOI":"10.1080\/21678421.2018.1452945"},{"key":"e_1_2_12_3_1","doi-asserted-by":"publisher","DOI":"10.1080\/21678421.2017.1354995"},{"key":"e_1_2_12_4_1","doi-asserted-by":"publisher","DOI":"10.1001\/jamaneurol.2017.3339"},{"key":"e_1_2_12_5_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00415\u2010020\u201009751\u20101"},{"key":"e_1_2_12_6_1","doi-asserted-by":"publisher","DOI":"10.1080\/21678421.2019.1587633"},{"key":"e_1_2_12_7_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00415\u2010022\u201010996\u20101"},{"key":"e_1_2_12_8_1","doi-asserted-by":"publisher","DOI":"10.1002\/ana.26285"},{"key":"e_1_2_12_9_1","doi-asserted-by":"publisher","DOI":"10.1038\/s43587\u2010024\u201000740\u2010x"},{"key":"e_1_2_12_10_1","doi-asserted-by":"publisher","DOI":"10.1002\/mus.28442"},{"key":"e_1_2_12_11_1","doi-asserted-by":"publisher","DOI":"10.1183\/09031936.00080312"},{"key":"e_1_2_12_12_1","doi-asserted-by":"publisher","DOI":"10.1001\/jamanetworkopen.2024.59058"},{"key":"e_1_2_12_13_1","doi-asserted-by":"publisher","DOI":"10.1001\/jamaneurol.2024.5249"},{"key":"e_1_2_12_14_1","doi-asserted-by":"publisher","DOI":"10.1001\/jama.2024.27643"},{"key":"e_1_2_12_15_1","doi-asserted-by":"publisher","DOI":"10.1001\/jama.2024.26429"},{"key":"e_1_2_12_16_1","doi-asserted-by":"publisher","DOI":"10.1164\/rccm.201908\u20101590ST"},{"key":"e_1_2_12_17_1","doi-asserted-by":"publisher","DOI":"10.1080\/10543400802527890"},{"key":"e_1_2_12_18_1","doi-asserted-by":"publisher","DOI":"10.1016\/S1474\u20104422(18)30089\u20109"},{"key":"e_1_2_12_19_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.0006\u2010341x.2000.00249.x"},{"key":"e_1_2_12_20_1","doi-asserted-by":"publisher","DOI":"10.1080\/21678421.2016.1249486"},{"key":"e_1_2_12_21_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jns.2022.120143"},{"key":"e_1_2_12_22_1","doi-asserted-by":"publisher","DOI":"10.3389\/fneur.2025.1588992"},{"key":"e_1_2_12_23_1","doi-asserted-by":"publisher","DOI":"10.3389\/fneur.2022.938256"}],"container-title":["Muscle & Nerve"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/mus.70322","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1002\/mus.70322","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/mus.70322","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,8,13]],"date-time":"2026-08-13T13:51:55Z","timestamp":1786629115000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/mus.70322"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,6,28]]},"references-count":22,"journal-issue":{"issue":"3","published-print":{"date-parts":[[2026,9]]}},"alternative-id":["10.1002\/mus.70322"],"URL":"https:\/\/doi.org\/10.1002\/mus.70322","archive":["Portico"],"relation":{},"ISSN":["0148-639X","1097-4598"],"issn-type":[{"value":"0148-639X","type":"print"},{"value":"1097-4598","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,6,28]]},"assertion":[{"value":"2025-10-29","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2026-06-05","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2026-06-28","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}