{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,13]],"date-time":"2026-08-13T14:42:18Z","timestamp":1786632138903,"version":"build-2736575974"},"reference-count":29,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2026,7,17]],"date-time":"2026-07-17T00:00:00Z","timestamp":1784246400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"},{"start":{"date-parts":[[2026,7,17]],"date-time":"2026-07-17T00:00:00Z","timestamp":1784246400000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Muscle and Nerve"],"published-print":{"date-parts":[[2026,9]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Introduction<\/jats:title>\n                    <jats:p>Sexuality is a relevant yet understudied aspect in people living with motor neuron disease (MND). This study aimed to assess whether sexuality in people with MND is influenced by motor, cognitive, behavioral, or mood disturbances, and to explore whether being sexually active impacts caregiver burden.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>We conducted a cross\u2010sectional observational study involving participants with MND and their primary caregivers from three ALS multidisciplinary units in Seville, Spain. Data were collected between October 2018 and July 2021. Functional, cognitive, behavioral, and mood assessments were conducted. Sexuality was evaluated through sex\u2010specific questionnaires. Caregiver burden was assessed using the Zarit Burden Interview.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      Among 66 participants who completed the sexuality assessment, 42.9% reported sexual activity in the previous month. Of these, 70% had no sexual dysfunction, while 26.7% had moderate and 3.3% severe dysfunction. No correlation was found between sexual activity and motor function. Sexual activity was less frequent in participants with apathy (\n                      <jats:italic>p<\/jats:italic>\n                      \u2009=\u20090.026), depression (\n                      <jats:italic>p<\/jats:italic>\n                      \u2009=\u20090.021), and frontotemporal dementia (\n                      <jats:italic>p<\/jats:italic>\n                      \u2009=\u20090.013). Among sexually active patients, those with cognitive impairment\u2014particularly memory dysfunction\u2014had higher rates of orgasm difficulties (\n                      <jats:italic>p<\/jats:italic>\n                      \u2009=\u20090.019). No other clinical parameters were related to sexuality. Sexuality of participants with MND did not influence caregiver burden.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Discussion<\/jats:title>\n                    <jats:p>Sexuality in MND is more associated with cognitive and mood factors than with motor disability. Addressing sexuality in clinical practice may contribute to improving quality of life and should be integrated into the multidisciplinary care of MND patients.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1002\/mus.70348","type":"journal-article","created":{"date-parts":[[2026,7,18]],"date-time":"2026-07-18T05:00:43Z","timestamp":1784350843000},"page":"669-677","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Impact of Sexuality in Patients With Motor Neuron Disease"],"prefix":"10.1002","volume":"74","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-7591-4446","authenticated-orcid":false,"given":"R. Yolanda","family":"Morgado Linares","sequence":"first","affiliation":[{"name":"Neuromuscular Disorders Unit, Department of Neurology Hospital Universitario Virgen Macarena  Sevilla Spain"},{"name":"Neuromuscular Disorders Unit, Department of Neurology Hospital Universitario de Valme  Sevilla Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4142-4283","authenticated-orcid":false,"given":"\u00cd\u00f1igo","family":"Rojas\u2010Marcos","sequence":"additional","affiliation":[{"name":"Neuromuscular Disorders Unit, Department of Neurology Instituto de Biomedicina de Sevilla, Hospital U. Virgen del Roc\u00edo\/CSIC\/Universidad de Sevilla  Sevilla Spain"},{"name":"Centro de Investigaci\u00f3n Biom\u00e9dica en Red sobre Enfermedades Neurodegenerativas (CIBERNED)  Madrid Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marco","family":"Mesa","sequence":"additional","affiliation":[{"name":"Hospital Universitario Virgen del Roc\u00edo  Sevilla Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Eva","family":"Mart\u00ednez","sequence":"additional","affiliation":[{"name":"Neuromuscular Disorders Unit, Department of Neurology Hospital Universitario Virgen Macarena  Sevilla Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3109-6095","authenticated-orcid":false,"given":"Macarena","family":"Cabrera\u2010Serrano","sequence":"additional","affiliation":[{"name":"Neuromuscular Disorders Unit, Department of Neurology Instituto de Biomedicina de Sevilla, Hospital U. Virgen del Roc\u00edo\/CSIC\/Universidad de Sevilla  Sevilla Spain"},{"name":"Centro de Investigaci\u00f3n Biom\u00e9dica en Red sobre Enfermedades Neurodegenerativas (CIBERNED)  Madrid Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6917-2236","authenticated-orcid":false,"given":"Carmen","family":"Paradas","sequence":"additional","affiliation":[{"name":"Neuromuscular Disorders Unit, Department of Neurology Instituto de Biomedicina de Sevilla, Hospital U. Virgen del Roc\u00edo\/CSIC\/Universidad de Sevilla  Sevilla Spain"},{"name":"Centro de Investigaci\u00f3n Biom\u00e9dica en Red sobre Enfermedades Neurodegenerativas (CIBERNED)  Madrid Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2026,7,17]]},"reference":[{"key":"e_1_2_11_2_1","doi-asserted-by":"publisher","DOI":"10.1007\/s13760\u2010022\u201002036\u20106"},{"issue":"3","key":"e_1_2_11_3_1","first-page":"212","article-title":"Sexual Intimacy in Persons With Amyotrophic Lateral Sclerosis and Their Partners: A Pilot Study","volume":"53","author":"Ramirez V.","year":"2024","journal-title":"Journal of Allied Health"},{"key":"e_1_2_11_4_1","doi-asserted-by":"publisher","DOI":"10.1007\/BF02260859"},{"key":"e_1_2_11_5_1","doi-asserted-by":"publisher","DOI":"10.1017\/S0033291798006667"},{"key":"e_1_2_11_6_1","doi-asserted-by":"publisher","DOI":"10.1136\/jnnp-2018-319684"},{"key":"e_1_2_11_7_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00415-004-0351-1"},{"key":"e_1_2_11_8_1","doi-asserted-by":"publisher","DOI":"10.1155\/2021\/5563343"},{"key":"e_1_2_11_9_1","doi-asserted-by":"publisher","DOI":"10.12968\/bjnn.2014.10.5.242"},{"key":"e_1_2_11_10_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0885-3924(03)00323-3"},{"key":"e_1_2_11_11_1","doi-asserted-by":"publisher","DOI":"10.3109\/17482968.2012.696658"},{"key":"e_1_2_11_12_1","doi-asserted-by":"publisher","DOI":"10.7748\/ns2010.12.25.15.40.c8207"},{"key":"e_1_2_11_13_1","doi-asserted-by":"publisher","DOI":"10.3233\/NRE-172204"},{"key":"e_1_2_11_14_1","doi-asserted-by":"publisher","DOI":"10.1590\/0004-282x20180061"},{"key":"e_1_2_11_15_1","doi-asserted-by":"publisher","DOI":"10.1080\/146608200300079536"},{"key":"e_1_2_11_16_1","doi-asserted-by":"publisher","DOI":"10.3109\/17482968.2010.489115"},{"key":"e_1_2_11_17_1","doi-asserted-by":"publisher","DOI":"10.1080\/21678421.2017.1406952"},{"key":"e_1_2_11_18_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0163-8343(03)00043-4"},{"issue":"4","key":"e_1_2_11_19_1","first-page":"338","article-title":"Adaptaci\u00f3n Para Nuestro Medio de la Escala de Sobrecarga del Cuidador (Caregiver Burden Interview) de Zarit","volume":"6","author":"Mart\u00edn Carrasco M.","year":"1996","journal-title":"Revue de Gerontologie"},{"key":"e_1_2_11_20_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0212-6567(04)79497-4"},{"key":"e_1_2_11_21_1","doi-asserted-by":"publisher","DOI":"10.1093\/brain\/awr179"},{"key":"e_1_2_11_22_1","doi-asserted-by":"publisher","DOI":"10.1080\/19317611.2024.2318388"},{"key":"e_1_2_11_23_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1743-6109.2011.02511.x"},{"key":"e_1_2_11_24_1","unstructured":"Instituto Nacional Estad\u00edstica \u201cEncuesta de Salud y H\u00e1bitos Sexuales 2003 \u201dNIPO 60507024\u20104 2009 https:\/\/www.ine.es\/ss\/Satellite?L=es_ES&c=INEPublicacion_C&cid=1259924965002&p=1254735110672&pagename=ProductosYServicios%2FPYSLayout&param1=PYSDetalleGratuitas."},{"issue":"39","key":"e_1_2_11_25_1","first-page":"645","article-title":"Health, Sexual Activity, and Sexual Satisfaction","volume":"117","author":"Dekker A.","year":"2020","journal-title":"Deutsches \u00c4rzteblatt International"},{"key":"e_1_2_11_26_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jagp.2014.03.006"},{"key":"e_1_2_11_27_1","doi-asserted-by":"publisher","DOI":"10.3109\/17482960903307797"},{"key":"e_1_2_11_28_1","doi-asserted-by":"publisher","DOI":"10.1017\/S1041610216001642"},{"key":"e_1_2_11_29_1","doi-asserted-by":"publisher","DOI":"10.1159\/000522042"},{"key":"e_1_2_11_30_1","doi-asserted-by":"publisher","DOI":"10.1080\/17482960601073543"}],"container-title":["Muscle &amp; 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