{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,7]],"date-time":"2026-09-07T15:10:36Z","timestamp":1788793836002,"version":"build-2803163510"},"reference-count":33,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2026,8,3]],"date-time":"2026-08-03T00:00:00Z","timestamp":1785715200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"},{"start":{"date-parts":[[2026,8,3]],"date-time":"2026-08-03T00:00:00Z","timestamp":1785715200000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Muscle and Nerve"],"published-print":{"date-parts":[[2026,10]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Introduction\/Aims<\/jats:title>\n                    <jats:p>Sensory cortical hyperexcitability, reflected by enlarged median nerve somatosensory evoked potentials (SEPs), has been reported in amyotrophic lateral sclerosis (ALS) and is associated with shorter survival. This study investigated whether similar changes involve the ulnar nerve representation within the hand area of the primary somatosensory cortex and examined their relationship with survival.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>Ninety\u2010nine patients with sporadic ALS and 42 healthy controls were retrospectively studied. Sensory nerve action potentials (SNAPs) and SEPs were recorded following median and ulnar nerve stimulation. SNAP amplitudes and the peak\u2010to\u2010peak amplitudes between N20 and P25 (N20p\u2010P25p) were compared between groups. Patients were followed until death or tracheostomy, and associations between SEP amplitudes and survival were analyzed using Kaplan\u2013Meier and Cox proportional hazards analyses.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      SNAP amplitudes did not differ between patients and controls. In contrast, patients with ALS showed larger N20p\u2010P25p amplitudes for both median and ulnar nerve SEPs. N20p\u2010P25p amplitudes were positively correlated between the two nerves, and the ulnar\u2010to\u2010median amplitude ratio did not differ from controls. Patients with ulnar N20p\u2010P25p\u2009\u2265\u20094.89\u2009\u03bcV had significantly shorter survival than those with lower amplitude (log\u2010rank test,\n                      <jats:italic>p<\/jats:italic>\n                      \u2009=\u20090.035). Multivariate Cox analysis identified increased N20p\u2010P25p amplitude as an independent predictor of shorter survival for both nerves.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Discussion<\/jats:title>\n                    <jats:p>Sensory cortical hyperexcitability in ALS extends beyond the median nerve to the ulnar nerve hand area of the somatosensory cortex. Its association with survival supports the notion that sensory cortical dysfunction represents a fundamental pathophysiological feature of ALS and a potential electrophysiological prognostic marker.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1002\/mus.70371","type":"journal-article","created":{"date-parts":[[2026,8,4]],"date-time":"2026-08-04T05:18:42Z","timestamp":1785820722000},"page":"1246-1255","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Sensory Cortical Hyperexcitability in Amyotrophic Lateral Sclerosis Involves a Broad Hand Representation Within the Primary Somatosensory Cortex"],"prefix":"10.1002","volume":"74","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-6625-2249","authenticated-orcid":false,"given":"Yoshiyuki","family":"Matsuki","sequence":"first","affiliation":[{"name":"Department of Neurology Tokyo Metropolitan Neurological Hospital  Fuchu Tokyo 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Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3158-6265","authenticated-orcid":false,"given":"Hideki","family":"Kimura","sequence":"additional","affiliation":[{"name":"Department of Neurology Tokyo Metropolitan Neurological Hospital  Fuchu Tokyo Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2904-6080","authenticated-orcid":false,"given":"Kazushi","family":"Takahashi","sequence":"additional","affiliation":[{"name":"Department of Neurology Tokyo Metropolitan Neurological Hospital  Fuchu Tokyo Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8620-612X","authenticated-orcid":false,"given":"Yuki","family":"Nakayama","sequence":"additional","affiliation":[{"name":"Unit for Intractable Disease Nursing Care Tokyo Metropolitan Institute of Medical Science  Setagaya Tokyo 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