{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,7]],"date-time":"2026-10-07T17:01:10Z","timestamp":1791392470312,"version":"4.3.3"},"reference-count":43,"publisher":"Wiley","issue":"5","license":[{"start":{"date-parts":[[2026,8,28]],"date-time":"2026-08-28T00:00:00Z","timestamp":1787875200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"},{"start":{"date-parts":[[2026,8,28]],"date-time":"2026-08-28T00:00:00Z","timestamp":1787875200000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Muscle and Nerve"],"published-print":{"date-parts":[[2026,11]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Introduction\/Aims<\/jats:title>\n                    <jats:p>In the era of disease modifying treatments (DMT), early\u2010onset scoliosis may occur despite administration to infants with spinal muscular atrophy (SMA). We hypothesize that postural torticollis (Ptort), defined as tilt and\/or rotation of the head to the same side due to an assumed asymmetry in cervical muscle strength, could be playing a role in early\u2010onset scoliosis (EOS). The aim of this study was to assess the frequency of Ptort and EOS in infants with SMA.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>\n                      Clinical data was collected retrospectively on infants with SMA identified by newborn screening (NBS) seen at a single institution, including\n                      <jats:italic>SMN2<\/jats:italic>\n                      copy number; presence of torticollis, scoliosis, or both; and the date at which the patient received DMT. When available, spinal x\u2010ray results and Cobb angles were recorded.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      Twenty\u2010three patients with 2\u20135 copies of\n                      <jats:italic>SMN2<\/jats:italic>\n                      were included. Twenty (87%) were treated with DMT at a median age of 23.5\u2009days of life (range 8\u2013233\u2009days). High prevalences of Ptort (52%) and EOS (30.5%) were reported. Four infants (17.4%) were noted to have Ptort preceding the development of EOS.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Discussion<\/jats:title>\n                    <jats:p>Early identification of Ptort and vigilance for the development of scoliosis are warranted even in treated infants. Further longitudinal studies are needed to evaluate the factors that are associated with this clinical observation.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1002\/mus.70383","type":"journal-article","created":{"date-parts":[[2026,8,29]],"date-time":"2026-08-29T06:38:47Z","timestamp":1787985527000},"page":"1348-1357","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Postural Torticollis and Early\u2010Onset Scoliosis in Infants With\n                    <scp>SMA<\/scp>\n                    Identified Through Newborn Screening: Single Institution Experience"],"prefix":"10.1002","volume":"74","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-4376-4567","authenticated-orcid":false,"given":"Meghan","family":"Moore Burk","sequence":"first","affiliation":[{"name":"Children's Hospital Colorado  Aurora Colorado USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Carolyn","family":"Kelley","sequence":"additional","affiliation":[{"name":"Children's Hospital Colorado  Aurora Colorado USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sara","family":"Thinger","sequence":"additional","affiliation":[{"name":"Children's Hospital Colorado  Aurora Colorado USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hattie","family":"Foster","sequence":"additional","affiliation":[{"name":"Children's Hospital Colorado  Aurora Colorado USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0005-2096-6501","authenticated-orcid":false,"given":"Kelli","family":"Johnson","sequence":"additional","affiliation":[{"name":"Children's Hospital Colorado  Aurora Colorado USA"},{"name":"Department of Physical Medicine and Rehabilitation University of Colorado School of Medicine  Aurora Colorado 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