{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,24]],"date-time":"2026-09-24T10:11:31Z","timestamp":1790244691369,"version":"4.1.0"},"reference-count":18,"publisher":"Wiley","license":[{"start":{"date-parts":[[2026,9,24]],"date-time":"2026-09-24T00:00:00Z","timestamp":1790208000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"},{"start":{"date-parts":[[2026,9,24]],"date-time":"2026-09-24T00:00:00Z","timestamp":1790208000000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Muscle and Nerve"],"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Introduction\/Aims<\/jats:title>\n                    <jats:p>Phrenic nerve involvement in neuralgic amyotrophy (NA) may cause diaphragm paresis and respiratory impairment, for which chronic non\u2010invasive ventilation (NIV) may be beneficial. Data on treatment success and predictors are lacking. This study evaluated NIV treatment success and its predictors in NA patients with diaphragm paresis.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>Clinical data of all NA patients initiated on chronic NIV at the Centre of Home Mechanical Ventilation (Maastricht, the Netherlands) between September 2008 and April 2023 were retrospectively analyzed. Successful NIV use was defined as continued NIV or successful step\u2010down due to clinical improvement. Cox proportional\u2010hazards regression analyses were performed to identify predictors of successful outcome.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>Fifty\u2010four patients (mean age 62.5\u2009\u00b1\u200910.9\u2009years; 72.2% male) were included. Mean baseline postural decline in forced vital capacity (\u0394FVC) was \u221235.1%\u2009\u00b1\u200919.6%. Median NIV adherence was 6.4 [3.6\u20138.1] hours\/day. Thirty\u2010eight patients (70.4%) continued NIV during a mean follow\u2010up of 4.9\u2009years. Of these, six (11%) were successfully stepped down from NIV following clinical and\/or functional improvement. Sixteen patients discontinued NIV because of lack of effect or intolerance. Baseline \u0394FVC (sitting to supine) independently predicted successful NIV use (HR 0.947; 95% CI: 0.91\u20130.99).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Discussion<\/jats:title>\n                    <jats:p>Chronic NIV was successful in most NA patients with diaphragm paresis, supporting its role as a long\u2010term treatment option. Greater postural decline in FVC predicted treatment success, suggesting that postural spirometry may help identify patients most likely to benefit from NIV.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1002\/mus.70403","type":"journal-article","created":{"date-parts":[[2026,9,24]],"date-time":"2026-09-24T09:52:41Z","timestamp":1790243561000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Predictors for Successful Non\u2010Invasive Ventilation in Patients With Neuralgic Amyotrophy and Phrenic Nerve Involvement"],"prefix":"10.1002","author":[{"ORCID":"https:\/\/orcid.org\/0009-0007-6580-5618","authenticated-orcid":false,"given":"A. B.","family":"Hendrikx","sequence":"first","affiliation":[{"name":"Centre for Home Mechanical Ventilation Maastricht (CHMV) Maastricht University Medical Centre  Maastricht the Netherlands"},{"name":"Department of Respiratory Medicine Maastricht University Medical Centre  Maastricht the Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2844-3500","authenticated-orcid":false,"given":"R. T.","family":"Sprooten","sequence":"additional","affiliation":[{"name":"Centre for Home Mechanical Ventilation Maastricht (CHMV) Maastricht University Medical Centre  Maastricht the Netherlands"},{"name":"Department of Respiratory Medicine Maastricht University Medical Centre  Maastricht the Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9324-1289","authenticated-orcid":false,"given":"B. A.","family":"Vosse","sequence":"additional","affiliation":[{"name":"Centre for Home Mechanical Ventilation Maastricht (CHMV) Maastricht University Medical Centre  Maastricht the Netherlands"},{"name":"Department of Respiratory Medicine Maastricht University Medical Centre  Maastricht the Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0277-2971","authenticated-orcid":false,"given":"S. C.","family":"Steijns","sequence":"additional","affiliation":[{"name":"Centre for Home Mechanical Ventilation Maastricht (CHMV) Maastricht University Medical Centre  Maastricht the Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2796-729X","authenticated-orcid":false,"given":"S. M.","family":"van Kuijk","sequence":"additional","affiliation":[{"name":"Department of Clinical Epidemiology and Medical Technical Assessment (KEMTA) Maastricht University Medical Centre  Maastricht the Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6940-0027","authenticated-orcid":false,"given":"J. G.","family":"Hoeijmakers","sequence":"additional","affiliation":[{"name":"Department of Neurology Maastricht University Medical Centre  Maastricht the Netherlands"},{"name":"Mental Health and Neuroscience Research Institute, Faculty of Health, Medicine and Life Sciences Maastricht University  Maastricht the Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1633-6356","authenticated-orcid":false,"given":"F. M.","family":"Franssen","sequence":"additional","affiliation":[{"name":"Department of Respiratory Medicine Maastricht University Medical Centre  Maastricht the Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2026,9,24]]},"reference":[{"key":"e_1_2_12_2_1","unstructured":"M. B.Bromberg \u201cBrachial Plexus Syndromes \u201d(2021) https:\/\/www.uptodate.com\/contents\/brachial\u2010plexus\u2010syndromes."},{"issue":"4","key":"e_1_2_12_3_1","doi-asserted-by":"crossref","first-page":"539","DOI":"10.1016\/j.jsmc.2020.08.002","article-title":"Phrenic Nerve Involvement in Neuralgic Amyotrophy (Parsonage\u2010Turner Syndrome)","volume":"15","author":"Farr E.","year":"2020","journal-title":"Sleep Medicine Clinics"},{"issue":"13","key":"e_1_2_12_4_1","doi-asserted-by":"crossref","first-page":"45","DOI":"10.2174\/1874306401913010045","article-title":"Use of Non\u2010Invasive Ventilation With Volume\u2010Assured Pressure Support in Neuralgic Amyotrophy With Bilateral Diaphragmatic Paralysis","volume":"8","author":"Diaz\u2010Abad M.","year":"2019","journal-title":"Open Respiratory Medicine Journal"},{"issue":"2","key":"e_1_2_12_5_1","doi-asserted-by":"crossref","first-page":"227","DOI":"10.1177\/1558944715627246","article-title":"Parsonage\u2010Turner Syndrome: Clinical and Epidemiological Features From a Hand Surgeon's Perspective","volume":"11","author":"Milner C. S.","year":"2016","journal-title":"Hand (N. Y.)"},{"key":"e_1_2_12_6_1","doi-asserted-by":"crossref","unstructured":"N.vanAlfen J.Doorduin M. H. J.vanRosmalen et\u00a0al. \u201cPhrenic Neuropathy and Diaphragm Dysfunction in Neuralgic Amyotrophy \u201d91 no.9(2018):e843\u2013e849.","DOI":"10.1212\/WNL.0000000000006076"},{"issue":"2","key":"e_1_2_12_7_1","doi-asserted-by":"crossref","first-page":"199","DOI":"10.1007\/s11420-010-9176-x","article-title":"Parsonage\u2010Turner Syndrome","volume":"6","author":"Feinberg J. H.","year":"2010","journal-title":"HSS Journal"},{"issue":"12","key":"e_1_2_12_8_1","doi-asserted-by":"crossref","first-page":"113","DOI":"10.3390\/jcm5120113","article-title":"Diaphragm Dysfunction: Diagnostic Approaches and Management Strategies","volume":"5","author":"Dub\u00e9 B.\u2010P.","year":"2016","journal-title":"Journal of Clinical Medicine"},{"issue":"4","key":"e_1_2_12_9_1","doi-asserted-by":"crossref","first-page":"223","DOI":"10.1016\/j.pulmoe.2018.10.008","article-title":"Diaphragmatic Dysfunction","volume":"25","author":"Ricoy J.","year":"2019","journal-title":"Pulmonology Journal"},{"issue":"1","key":"e_1_2_12_10_1","doi-asserted-by":"crossref","first-page":"8","DOI":"10.1159\/000521288","article-title":"Charlson Comorbidity Index: A Critical Review of Clinimetric Properties","volume":"91","author":"Charlson M. E.","year":"2022","journal-title":"Psychotherapy and Psychosomatics"},{"issue":"2017","key":"e_1_2_12_11_1","doi-asserted-by":"crossref","DOI":"10.1136\/bcr-2017-219892","article-title":"A Case of Progressive Orthopnoea and Shoulder Pain Secondary to Bilateral Diaphragmatic Paralysis","volume":"18","author":"Herbert A.","year":"2017","journal-title":"BML Case Reports"},{"key":"e_1_2_12_12_1","volume-title":"Principles and Practice of Sleep Medicine","author":"Kryger M. H.","year":"2022"},{"key":"e_1_2_12_13_1","volume-title":"West's Respiratory Physiology: The Essentials","author":"West J. B.","year":"2021"},{"key":"e_1_2_12_14_1","volume-title":"Fishman's Pulmonary Diseases and Disorders","author":"Fishman A. P.","year":"2023"},{"issue":"2","key":"e_1_2_12_15_1","doi-asserted-by":"crossref","first-page":"173","DOI":"10.1007\/s00408-016-9972-2","article-title":"Phrenic Nerve Palsy Secondary to Parsonage\u2010Turner Syndrome: A Diagnosis Commonly Overlooked","volume":"195","author":"McEnery T.","year":"2017","journal-title":"Lung"},{"issue":"6","key":"e_1_2_12_16_1","doi-asserted-by":"crossref","first-page":"986","DOI":"10.1002\/mus.24673","article-title":"Idiopathic Phrenic Neuropathies: A Case Series and Review of the Literature","volume":"52","author":"Podnar S.","year":"2015","journal-title":"Muscle & Nerve"},{"issue":"2","key":"e_1_2_12_17_1","doi-asserted-by":"crossref","first-page":"248","DOI":"10.1016\/0003-4975(90)90146-W","article-title":"Diaphragmatic Plication for Unilateral Diaphragmatic Paralysis: A 10\u2010Year Experience","volume":"49","author":"Graham D.","year":"1990","journal-title":"Annals of Thoracic Surgery"},{"key":"e_1_2_12_18_1","doi-asserted-by":"crossref","first-page":"111","DOI":"10.1186\/1749-8090-5-111","article-title":"Long\u2010Term Results of Diaphragmatic Plication in Adults With Unilateral Diaphragm Paralysis","volume":"5","author":"Celik S.","year":"2010","journal-title":"Journal of Cardiothoracic Surgery"},{"issue":"9","key":"e_1_2_12_19_1","first-page":"e843","article-title":"Phrenic Neuropathy and Diaphragm Dysfunction in Neuralgic Amyotrophy","volume":"91","author":"Alfen N.","year":"2018","journal-title":"Neurology"}],"container-title":["Muscle &amp; Nerve"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/mus.70403","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1002\/mus.70403","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/mus.70403","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,9,24]],"date-time":"2026-09-24T09:52:46Z","timestamp":1790243566000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/mus.70403"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,9,24]]},"references-count":18,"alternative-id":["10.1002\/mus.70403"],"URL":"https:\/\/doi.org\/10.1002\/mus.70403","archive":["Portico"],"relation":{},"ISSN":["0148-639X","1097-4598"],"issn-type":[{"value":"0148-639X","type":"print"},{"value":"1097-4598","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,9,24]]},"assertion":[{"value":"2026-02-26","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2026-09-04","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2026-09-24","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}],"article-number":"mus.70403"}}