{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,20]],"date-time":"2026-02-20T23:13:50Z","timestamp":1771629230856,"version":"3.50.1"},"reference-count":21,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2004,10,13]],"date-time":"2004-10-13T00:00:00Z","timestamp":1097625600000},"content-version":"vor","delay-in-days":9297,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Muscle and Nerve"],"published-print":{"date-parts":[[1979,5]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Muscle breakdown and repair were measured by metabolic balance techniques in a patient with polymyositis who was being treated with prednisolone and azathioprine. Changes in body muscle mass that had been estimated from nitrogen and phosphorus balances correlated with anthropometric assessments of thigh muscle mass and quadriceps strength. Decline in muscle strength was associated with a net rate of muscle breakdown of 148 g\/day. Recovery was associated with a net rate of muscle repair of up to 100 g\/day. Early reduction in corticosteroid treatment appeared to enhance the rate of repair. Changes in the isometric contraction force of the quadriceps muscle (but not in clinical symptoms, plasma creatine kinase [CK] or erythrocyte sedimentation rate [ESR]) were found to reliably indicate whether the muscle was in a state of breakdown or repair. Treatment of the individual patient may be quantitatively monitored by metabolic balance studies or, more simply, by measurement of muscle strength.<\/jats:p>","DOI":"10.1002\/mus.880020311","type":"journal-article","created":{"date-parts":[[2005,1,1]],"date-time":"2005-01-01T07:54:23Z","timestamp":1104566063000},"page":"223-228","source":"Crossref","is-referenced-by-count":26,"title":["Muscle breakdown and repair in polymyositis: A case study"],"prefix":"10.1002","volume":"2","author":[{"given":"H. T.","family":"Edwards","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"C. M.","family":"Wiles","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"J. M.","family":"Round","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"M. J.","family":"Jackson","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"A.","family":"Young","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2004,10,13]]},"reference":[{"key":"e_1_2_1_2_2","first-page":"303","volume-title":"The Parathyroid Glands and Metabolic Bone Disease","author":"Albright F.","year":"1948"},{"key":"e_1_2_1_3_2","doi-asserted-by":"publisher","DOI":"10.1056\/NEJM197502132920706"},{"key":"e_1_2_1_4_2","first-page":"351","article-title":"Polymyositis","volume":"17","author":"Bradley WG","year":"1977","journal-title":"Br J Hosp Med"},{"key":"e_1_2_1_5_2","first-page":"207","article-title":"Survival in polymyositis: corticosteroids and risk factors","volume":"4","author":"Carpenter JR","year":"1977","journal-title":"J Rheumatol"},{"key":"e_1_2_1_6_2","doi-asserted-by":"publisher","DOI":"10.1093\/brain\/98.4.637"},{"key":"e_1_2_1_7_2","doi-asserted-by":"publisher","DOI":"10.1136\/gut.10.5.408"},{"key":"e_1_2_1_8_2","doi-asserted-by":"publisher","DOI":"10.1042\/bj0740247"},{"key":"e_1_2_1_9_2","first-page":"516","volume-title":"Documenta Geigy, Scientific Tables","author":"Diem K","year":"1962"},{"key":"e_1_2_1_10_2","first-page":"20","volume-title":"Muscle Biopsy: A Modern Approach","author":"Dubowitz V","year":"1973"},{"key":"e_1_2_1_11_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(75)91642-6"},{"key":"e_1_2_1_12_2","first-page":"569","article-title":"Muscle biopsy","volume":"3","author":"Edwards RHT","year":"1977","journal-title":"Hosp Update"},{"key":"e_1_2_1_13_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(73)92672-X"},{"key":"e_1_2_1_14_2","doi-asserted-by":"publisher","DOI":"10.1042\/cs0520283"},{"key":"e_1_2_1_15_2","first-page":"63P","article-title":"Anthropometric determination of leg fat and muscle plus bone volume in young male and female adults","volume":"204","author":"Jones PRM","year":"1969","journal-title":"J Physiol (Lond)"},{"key":"e_1_2_1_16_2","first-page":"1","volume-title":"Medical Research Council Memorandum No 45: Aids to the Examination of the Peripheral Nervous System","year":"1976"},{"key":"e_1_2_1_17_2","first-page":"641","volume-title":"Disorders of Voluntary Muscle","author":"Pearson CM","year":"1974"},{"key":"e_1_2_1_18_2","doi-asserted-by":"publisher","DOI":"10.1016\/0022-510X(75)90115-X"},{"key":"e_1_2_1_19_2","first-page":"696","article-title":"An improved procedure for serum creatine phosphokinase determination","volume":"69","author":"Rosalki SB","year":"1967","journal-title":"J Lab Clin Med"},{"key":"e_1_2_1_20_2","doi-asserted-by":"publisher","DOI":"10.1093\/brain\/89.4.747"},{"key":"e_1_2_1_21_2","first-page":"201","article-title":"Assessment of physical capabilities with special reference to the evaluation of maximal voluntary isometric muscle strength and maximal working capacity","volume":"58","author":"Tornvall G","year":"1963","journal-title":"Acta Physiol Scand [Suppl.]"},{"key":"e_1_2_1_22_2","volume-title":"Polymyositis","author":"Walton JN","year":"1958"}],"container-title":["Muscle &amp; Nerve"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1002%2Fmus.880020311","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/mus.880020311","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,11,12]],"date-time":"2023-11-12T16:34:48Z","timestamp":1699806888000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/mus.880020311"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[1979,5]]},"references-count":21,"journal-issue":{"issue":"3","published-print":{"date-parts":[[1979,5]]}},"alternative-id":["10.1002\/mus.880020311"],"URL":"https:\/\/doi.org\/10.1002\/mus.880020311","archive":["Portico"],"relation":{},"ISSN":["0148-639X","1097-4598"],"issn-type":[{"value":"0148-639X","type":"print"},{"value":"1097-4598","type":"electronic"}],"subject":[],"published":{"date-parts":[[1979,5]]}}}