{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,30]],"date-time":"2026-04-30T10:00:50Z","timestamp":1777543250339,"version":"3.51.4"},"reference-count":27,"publisher":"Wiley","issue":"6","license":[{"start":{"date-parts":[[2004,10,13]],"date-time":"2004-10-13T00:00:00Z","timestamp":1097625600000},"content-version":"vor","delay-in-days":9113,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Muscle and Nerve"],"published-print":{"date-parts":[[1979,11]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Halothane, at clinical concentrations, depolarizes the plasma membrane of skeletal muscle from Poland China pigs susceptible to malignant hyperthermia but does not affect the resting membrane potential of muscle from normal Poland China pigs, mice, or frogs. The depolarization is reduced or partially reversed in the presence of dantrolene sodium. We suggest the possibility that malignant hyperthermia may be initiated by this abnormal depolarization of skeletal muscle by halothane.<\/jats:p>","DOI":"10.1002\/mus.880020610","type":"journal-article","created":{"date-parts":[[2005,1,1]],"date-time":"2005-01-01T05:06:20Z","timestamp":1104555980000},"page":"491-494","source":"Crossref","is-referenced-by-count":50,"title":["Role of plasma membrane defect of skeletal muscle in malignant hyperthermia"],"prefix":"10.1002","volume":"2","author":[{"given":"Esther M.","family":"Gallant","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Robert E.","family":"Godt","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Gerald A.","family":"Gronert","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2004,10,13]]},"reference":[{"key":"e_1_2_1_2_2","first-page":"103","volume-title":"The Second International Symposium on Malignant Hyperthermia","author":"Aldrete JA","year":"1978"},{"key":"e_1_2_1_3_2","first-page":"509","volume-title":"Second International Symposium on Malignant Hyperthermia","author":"Anderson IL","year":"1978"},{"key":"e_1_2_1_4_2","doi-asserted-by":"publisher","DOI":"10.1177\/00359157730661P133"},{"key":"e_1_2_1_5_2","doi-asserted-by":"publisher","DOI":"10.1007\/BF03026208"},{"key":"e_1_2_1_6_2","first-page":"9","volume-title":"Malignant Hyperthermia: Current Concepts","author":"Britt BA","year":"1977"},{"key":"e_1_2_1_7_2","doi-asserted-by":"publisher","DOI":"10.1038\/254364a0"},{"key":"e_1_2_1_8_2","first-page":"231","article-title":"Mechanical activation and electrophysiological properties of intercostal muscle fibers from malignant\u2010hyperthermia\u2010susceptible (MHS) pigs","volume":"30","author":"Bryant SH","year":"1977","journal-title":"Soc Neurosci"},{"key":"e_1_2_1_9_2","doi-asserted-by":"publisher","DOI":"10.1093\/bja\/31.7.302"},{"key":"e_1_2_1_10_2","first-page":"721","article-title":"Halothane\u2010induced muscle contracture as a cause of hyperprexia","volume":"43","author":"Ellis FR","year":"1971","journal-title":"Br J Anaesth"},{"key":"e_1_2_1_11_2","doi-asserted-by":"publisher","DOI":"10.1007\/BF00501011"},{"key":"e_1_2_1_12_2","doi-asserted-by":"publisher","DOI":"10.1007\/BF03006817"},{"key":"e_1_2_1_13_2","doi-asserted-by":"publisher","DOI":"10.1097\/00000542-197606000-00005"},{"key":"e_1_2_1_14_2","doi-asserted-by":"publisher","DOI":"10.1097\/00000542-197601000-00008"},{"key":"e_1_2_1_15_2","doi-asserted-by":"publisher","DOI":"10.1093\/bja\/48.4.305"},{"key":"e_1_2_1_16_2","doi-asserted-by":"publisher","DOI":"10.1093\/bja\/47.1.62"},{"key":"e_1_2_1_17_2","doi-asserted-by":"publisher","DOI":"10.1097\/00000542-197202000-00008"},{"key":"e_1_2_1_18_2","doi-asserted-by":"publisher","DOI":"10.1097\/00000542-196205000-00009"},{"key":"e_1_2_1_19_2","doi-asserted-by":"publisher","DOI":"10.1093\/bja\/48.4.297"},{"key":"e_1_2_1_20_2","first-page":"138","article-title":"The mechanism of action of dantrolene sodium","volume":"201","author":"Morgan KG","year":"1977","journal-title":"J Pharmacol Exp Ther"},{"key":"e_1_2_1_21_2","doi-asserted-by":"publisher","DOI":"10.1097\/00000542-197507000-00006"},{"key":"e_1_2_1_22_2","first-page":"23","volume-title":"Second International Symposium on Malignant Hyperthermia","author":"Nelson TE"},{"key":"e_1_2_1_23_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1440-1681.1977.tb02628.x"},{"key":"e_1_2_1_24_2","first-page":"202","article-title":"Site of action of dantrolene in frog sartorius muscle","volume":"189","author":"Putney JW","year":"1974","journal-title":"J Pharmacol Exp Ther"},{"key":"e_1_2_1_25_2","first-page":"394","article-title":"The action of Fluothane\u2014a new volatile anaesthetic","volume":"11","author":"Ravent\u00f3s J","year":"1956","journal-title":"Br J Anaesth"},{"key":"e_1_2_1_26_2","doi-asserted-by":"publisher","DOI":"10.1007\/BF00592693"},{"key":"e_1_2_1_27_2","doi-asserted-by":"publisher","DOI":"10.2170\/jjphysiol.25.747"},{"key":"e_1_2_1_28_2","doi-asserted-by":"publisher","DOI":"10.1126\/science.959824"}],"container-title":["Muscle &amp; 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