{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,28]],"date-time":"2025-10-28T10:28:38Z","timestamp":1761647318104},"reference-count":34,"publisher":"Wiley","issue":"6","license":[{"start":{"date-parts":[[2004,10,13]],"date-time":"2004-10-13T00:00:00Z","timestamp":1097625600000},"content-version":"vor","delay-in-days":8747,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Muscle and Nerve"],"published-print":{"date-parts":[[1980,11]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Sixteen patients presenting with trophic changes associated with a peripheral neuropathy were investigated. Muscle power was normal in all patients, but neurogenic muscle atrophy was demonstrated in 4 of the 7 patients who had a muscle biopsy. Alcoholism was responsible for the neuropathy in 11 patients. In the other patients, one had primary hemochromatosis without diabetes and another a dominantly inherited primary hypertrophic neuropathy. Qualitative and quantitative light and electron microscopic studies, including teased nerve fiber preparations, showed axonal loss as the most salient feature. In the alcoholic patients, the large myelinated fibers were primarily involved, followed by small myelinated and unmyelinated fibers. The lesions were predominant distally as shown in patients who had a sural nerve biopsy at both calf and ankle levels. A mechanism of dying\u2010back degeneration of the longest sensory fibers is the most plausible explanation for neurological and pathological abnormalities. In alcoholic neuropathy with trophic changes, loss of sensory fibers is more important than in alcoholic neuropathy without trophic changes. In familial and sporadic cases, axonal loss is more severe and unmyelinated fibers are more severely affected than in alcoholic acrodystrophic neuropathy. Patients with peripheral neuropathies who present with loss of pain sensation but have preserved muscle power are especially exposed to the development of trophic changes induced by usual trauma in insensitive tissues.<\/jats:p>","DOI":"10.1002\/mus.880030606","type":"journal-article","created":{"date-parts":[[2005,1,1]],"date-time":"2005-01-01T07:57:34Z","timestamp":1104566254000},"page":"491-501","source":"Crossref","is-referenced-by-count":31,"title":["A clinicopathologic study of acrodystrophic neuropathies"],"prefix":"10.1002","volume":"3","author":[{"given":"Gerard","family":"Said","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2004,10,13]]},"reference":[{"key":"e_1_2_1_2_2","doi-asserted-by":"publisher","DOI":"10.1016\/0022-510X(73)90120-2"},{"key":"e_1_2_1_3_2","doi-asserted-by":"publisher","DOI":"10.1007\/BF00687600"},{"key":"e_1_2_1_4_2","doi-asserted-by":"publisher","DOI":"10.1002\/ana.410020203"},{"key":"e_1_2_1_5_2","first-page":"1023","article-title":"Acropathie ulc\u00e9ro\u2010mutilante des membres inf\u00e9rieurs: image histologique de \u201cn\u00e9vrite hypertrophique.\u201d","volume":"134","author":"Bergoujnan M","year":"1957","journal-title":"J Med Bordeaux"},{"key":"e_1_2_1_6_2","first-page":"1419","article-title":"Acropathies pseudosyringomyeliques des membres inf\u00e9rieurs","volume":"31","author":"Bureau Y","year":"1955","journal-title":"Sem Hop Paris"},{"key":"e_1_2_1_7_2","doi-asserted-by":"publisher","DOI":"10.1002\/ar.1090750305"},{"key":"e_1_2_1_8_2","first-page":"1187","article-title":"N\u00e9vrite hypertrophique non familiale (\u00e9tude anatomo\u2010clinique)","volume":"37","author":"Cornil L","year":"1930","journal-title":"Rev Neurol (Paris)"},{"key":"e_1_2_1_9_2","doi-asserted-by":"publisher","DOI":"10.1136\/jnnp.14.4.237"},{"key":"e_1_2_1_10_2","first-page":"296","volume-title":"Peripheral Neuropathy","author":"Dyck PJ","year":"1975"},{"key":"e_1_2_1_11_2","doi-asserted-by":"publisher","DOI":"10.1093\/brain\/95.2.223"},{"key":"e_1_2_1_12_2","doi-asserted-by":"publisher","DOI":"10.1001\/archneur.1969.00480110054005"},{"key":"e_1_2_1_13_2","first-page":"791","volume-title":"Peripheral Neuropathy","author":"Dyck PJ","year":"1975"},{"key":"e_1_2_1_14_2","doi-asserted-by":"publisher","DOI":"10.1001\/archneurpsyc.1952.02320130007001"},{"key":"e_1_2_1_15_2","first-page":"11","article-title":"Contribution \u00e0 l'\u00e9tude anatomique de la n\u00e9vrite parenchymateuse subaigu\u00eb ou chronique. 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Th\u00e8se de M\u00e9decine Paris 1855."},{"key":"e_1_2_1_19_2","first-page":"367","article-title":"N\u00e9vrite interstitielle hypertrophique","volume":"1","author":"Lesniowski St","year":"1931","journal-title":"Rev Neurol (Paris)"},{"key":"e_1_2_1_20_2","first-page":"897","article-title":"La forme dite sporadique de l'acropathie ulc\u00e9ro\u2010mutilante","volume":"12","author":"Mouren P","year":"1964","journal-title":"Marseille Med"},{"key":"e_1_2_1_21_2","first-page":"131","volume-title":"Peripheral Neuropathy","author":"Ochoa J","year":"1975"},{"key":"e_1_2_1_22_2","first-page":"142","article-title":"Acropathie ulc\u00e9ro\u2010multilante avec r\u00e9tinite pigmentaire et troubles vestibul\u00e1ires","volume":"122","author":"Raverdy Ph","year":"1970","journal-title":"Rev Neurol (Paris)"},{"key":"e_1_2_1_23_2","first-page":"427","article-title":"Sept cas d'une maladie familiale particuli\u00e8re: trouble de la marche, pieds bots, areflexie tendineuse g\u00e9n\u00e9ralis\u00e9e avec accessoirement l\u00e9g\u00e8re maladresse des mains","volume":"1","author":"Roussy G","year":"1926","journal-title":"Rev Neurol (Paris)"},{"key":"e_1_2_1_24_2","first-page":"1166","volume-title":"Peripheral Neuropathy","author":"Sabin TD","year":"1975"},{"key":"e_1_2_1_25_2","first-page":"467","article-title":"Etude des fibres nerveuses isol\u00e9es dans les n\u00e9vrites hypertrophiques primitives","volume":"132","author":"Said G","year":"1976","journal-title":"Rev Neurol (Paris)"},{"key":"e_1_2_1_26_2","doi-asserted-by":"publisher","DOI":"10.1016\/0022-510X(78)90012-6"},{"key":"e_1_2_1_27_2","volume-title":"Acrodystrophic Neuropathy","author":"Spillane JD","year":"1969"},{"key":"e_1_2_1_28_2","first-page":"345","article-title":"Electrical properties of dying\u2010back axons","volume":"28","author":"Sumner A","year":"1978","journal-title":"Neurology (Minneap)"},{"key":"e_1_2_1_29_2","first-page":"193","article-title":"L'acropathie ulc\u00e9ro\u2010mutilante familiale","volume":"74","author":"Thevenard A","year":"1942","journal-title":"Rev Neurol (Paris)"},{"key":"e_1_2_1_30_2","first-page":"1","article-title":"L'acropathie ulc\u00e9ro\u2010mutilante","volume":"53","author":"Thevenard A","year":"1953","journal-title":"Acta Neurol Belg"},{"key":"e_1_2_1_31_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1469-1809.1974.tb01945.x"},{"key":"e_1_2_1_32_2","doi-asserted-by":"publisher","DOI":"10.1016\/0022-510X(75)90155-0"},{"key":"e_1_2_1_33_2","first-page":"37","article-title":"Etude histo\u2010pathologique d'une observation d'arthropathie mutilante sym\u00e9trique familiale","volume":"53","author":"Van Bogaert L","year":"1953","journal-title":"Acta Neurol Belg"},{"key":"e_1_2_1_34_2","doi-asserted-by":"publisher","DOI":"10.1016\/0022-510X(70)90025-0"},{"key":"e_1_2_1_35_2","first-page":"73","volume-title":"Handbook of Clinical Neurology","author":"Wells CEC","year":"1975"}],"container-title":["Muscle &amp; Nerve"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1002%2Fmus.880030606","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/mus.880030606","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,11,12]],"date-time":"2023-11-12T15:13:05Z","timestamp":1699801985000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/mus.880030606"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[1980,11]]},"references-count":34,"journal-issue":{"issue":"6","published-print":{"date-parts":[[1980,11]]}},"alternative-id":["10.1002\/mus.880030606"],"URL":"https:\/\/doi.org\/10.1002\/mus.880030606","archive":["Portico"],"relation":{},"ISSN":["0148-639X","1097-4598"],"issn-type":[{"value":"0148-639X","type":"print"},{"value":"1097-4598","type":"electronic"}],"subject":[],"published":{"date-parts":[[1980,11]]}}}