{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,20]],"date-time":"2025-10-20T10:05:03Z","timestamp":1760954703736},"reference-count":32,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2004,10,13]],"date-time":"2004-10-13T00:00:00Z","timestamp":1097625600000},"content-version":"vor","delay-in-days":8262,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Muscle and Nerve"],"published-print":{"date-parts":[[1982,3]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>In order to determine whether branched\u2010chain ketoacids can reduce the excessive rate of muscle protein degradation that characterizes Duchenne muscular dystrophy, nine boys affected with the disease were studied in a metabolic ward while receiving meat\u2010free diets. After a three\u2010day equilibration period, excretion rates of 3\u2010methylhistidine and creatinine were measured in two consecutive four\u2010day periods. In the second period, a supplement containing a mixture of ornithine \u03b1\u2010ketoisocaproate, \u03b1\u2010ketoisovalerate, and \u03b1\u2010keto\u2010\u03b2\u2010methylvalerate in a proportion of 4 : 1 : 1 was administered orally at a dosage of 0.45 gm\/kg\/day. During treatment with the ketoacids, 3\u2010methylhistidine excretion fell by a small (mean: 14%) but highly significant (<jats:italic>P<\/jats:italic> &lt; 0.01) extent, whether expressed in absolute terms or in relation to creatinine excretion. No adverse effects were noted. We conclude that this mixture of ketoacids acutely reduces muscle protein degradation in patients with Duchenne muscular dystrophy.<\/jats:p>","DOI":"10.1002\/mus.880050304","type":"journal-article","created":{"date-parts":[[2005,1,1]],"date-time":"2005-01-01T08:02:30Z","timestamp":1104566550000},"page":"197-201","source":"Crossref","is-referenced-by-count":20,"title":["Branched\u2010chain ketoacids reduce muscle protein degradation in duchenne muscular dystrophy"],"prefix":"10.1002","volume":"5","author":[{"given":"Peter M.","family":"Stewart","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mackenzie","family":"Walser","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Daniel 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