{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,8]],"date-time":"2026-02-08T13:27:32Z","timestamp":1770557252486,"version":"3.49.0"},"reference-count":22,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2004,10,13]],"date-time":"2004-10-13T00:00:00Z","timestamp":1097625600000},"content-version":"vor","delay-in-days":7897,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Muscle and Nerve"],"published-print":{"date-parts":[[1983,3]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Three patients with Hypokalemic Periodic Paralysis (HOPP)\u2010associated progressive interattack muscle weakness, who became unresponsive or worsened by acetazolamide, responded favorably to dichloro\u2010phenamide, a more potent carbonic anhydrase inhibitor. Dichloro\u2010phenamide in single\u2010blind placebo\u2010controlled trials, considerably improved functional strength in two of the patients and had a moderate but definite effect in the third. Muscle groups graded 4\/5 (MRC scale) returned to normal; very weak (0\u20133\/5) atrophic muscles, improved to a minor degree. In one patient with acetazolamide\u2010resistant paralytic attacks, dichlorophenamide also diminished the frequency and severity of the acute attacks. Dichlorophenamide had, in the present study, less effect than acetazolamide in reducing serum HCO<jats:inline-graphic xmlns:xlink=\"http:\/\/www.w3.org\/1999\/xlink\" xlink:href=\"graphic\/tex2gif-stack-1.gif\" xlink:title=\"urn:x-wiley:0148639X:media:MUS880060303:tex2gif-stack-1\"\/> and elevating Cl<jats:sup>\u2212<\/jats:sup>. Its effectiveness may be related to the degree of sensitivity of certain HOPP patients to alterations of Cl<jats:sup>\u2212<\/jats:sup> and\/or HCO<jats:inline-graphic xmlns:xlink=\"http:\/\/www.w3.org\/1999\/xlink\" xlink:href=\"graphic\/tex2gif-stack-2.gif\" xlink:title=\"urn:x-wiley:0148639X:media:MUS880060303:tex2gif-stack-2\"\/> serum levels or to a different action of the drug unrelated to carbonic anhydrase inhibition or acidosis. Dichlorophenamide should be considered as an alternate to acetazolamide in the treatment of patients with HOPP\u2010associated interattack muscle weakness who have become unresponsive or worsened by acetazolamide.<\/jats:p>","DOI":"10.1002\/mus.880060303","type":"journal-article","created":{"date-parts":[[2005,1,1]],"date-time":"2005-01-01T08:06:18Z","timestamp":1104566778000},"page":"182-186","source":"Crossref","is-referenced-by-count":50,"title":["Treatment of \u201cpermanent\u201d muscle weakness in familial hypokalemic periodic paralysis"],"prefix":"10.1002","volume":"6","author":[{"given":"Marinos C.","family":"Dalakas","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"W. King","family":"Engel","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2004,10,13]]},"reference":[{"key":"e_1_2_1_2_2","unstructured":"BeverKH:Dichlorophenamide: preclinical evaluation as a natriuretic agent. Merck Sharp and Dohme Research Laboratories 1956."},{"key":"e_1_2_1_3_2","first-page":"379","article-title":"Treatment of \u201cpermanent\u201d muscle weakness in hypokalemic periodic paralysis","volume":"30","author":"Dalakas MC","year":"1980","journal-title":"Neurology (NY)"},{"key":"e_1_2_1_4_2","doi-asserted-by":"publisher","DOI":"10.1001\/archneur.1970.00480200003001"},{"key":"e_1_2_1_5_2","doi-asserted-by":"publisher","DOI":"10.1001\/archopht.1958.00940080445012"},{"key":"e_1_2_1_6_2","doi-asserted-by":"publisher","DOI":"10.7326\/0003-4819-73-1-39"},{"key":"e_1_2_1_7_2","doi-asserted-by":"publisher","DOI":"10.1002\/ana.410030614"},{"key":"e_1_2_1_8_2","doi-asserted-by":"publisher","DOI":"10.1177\/28.5.6769996"},{"key":"e_1_2_1_9_2","doi-asserted-by":"publisher","DOI":"10.1136\/bjo.45.2.125"},{"key":"e_1_2_1_10_2","first-page":"10","volume-title":"American Hospital Formulary Service","author":"McEnvoy GK","year":"1980"},{"key":"e_1_2_1_11_2","first-page":"129","article-title":"Hereditary periodic paralysis. II. Effects of fasting and of various types of diet on occurrence of paralytic attacks","volume":"1","author":"McQuarrie I","year":"1952","journal-title":"Metabolism"},{"key":"e_1_2_1_12_2","doi-asserted-by":"publisher","DOI":"10.1042\/bj1680567"},{"key":"e_1_2_1_13_2","first-page":"896","volume-title":"The Pharmacological Basis of Therapeutics","author":"Mudge GH","year":"1980"},{"key":"e_1_2_1_14_2","doi-asserted-by":"publisher","DOI":"10.1093\/brain\/87.2.341"},{"key":"e_1_2_1_15_2","first-page":"378","article-title":"Alterations in the sarcolemmal adenylate cyclase activity (AC\u2010a) in myotonia","volume":"27","author":"Reddy NM","year":"1977","journal-title":"Neurology (Minneap)"},{"key":"e_1_2_1_16_2","doi-asserted-by":"publisher","DOI":"10.1056\/NEJM196803142781102"},{"key":"e_1_2_1_17_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1748-1716.1979.tb06393.x"},{"key":"e_1_2_1_18_2","doi-asserted-by":"publisher","DOI":"10.1097\/00000441-195802000-00009"},{"key":"e_1_2_1_19_2","doi-asserted-by":"publisher","DOI":"10.1172\/JCI107529"},{"key":"e_1_2_1_20_2","doi-asserted-by":"publisher","DOI":"10.1016\/0014-4886(61)90006-1"},{"key":"e_1_2_1_21_2","first-page":"1054","article-title":"Potassium metabolism during diuretic therapy","volume":"24","author":"Talso PJ","year":"1961","journal-title":"Circulation"},{"key":"e_1_2_1_22_2","doi-asserted-by":"publisher","DOI":"10.1212\/WNL.31.11.1423"},{"key":"e_1_2_1_23_2","doi-asserted-by":"publisher","DOI":"10.1001\/archneur.1975.00490480051006"}],"container-title":["Muscle &amp; Nerve"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1002%2Fmus.880060303","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/mus.880060303","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,10,20]],"date-time":"2023-10-20T11:01:49Z","timestamp":1697799709000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/mus.880060303"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[1983,3]]},"references-count":22,"journal-issue":{"issue":"3","published-print":{"date-parts":[[1983,3]]}},"alternative-id":["10.1002\/mus.880060303"],"URL":"https:\/\/doi.org\/10.1002\/mus.880060303","archive":["Portico"],"relation":{},"ISSN":["0148-639X","1097-4598"],"issn-type":[{"value":"0148-639X","type":"print"},{"value":"1097-4598","type":"electronic"}],"subject":[],"published":{"date-parts":[[1983,3]]}}}