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The sensitivity also was increased in Duchenne muscular dystrophy or asymptomatic patients with raised serum creatine kinase activity. Judging from the interaction between caffeine and the contractile system, the abnormal response originated from the sarcoplasmic reticulum in malignant hyperthermia. In Duchenne muscular dystrophy, the contractile system also might be involved in the increased sensitivity. Since the disease spectrum presenting abnormal responses is broad, it is suggested that muscle fibers become sensitive to caffeine when they are degenerating or regenerating.<\/jats:p>","DOI":"10.1002\/mus.880060707","type":"journal-article","created":{"date-parts":[[2005,1,1]],"date-time":"2005-01-01T04:38:59Z","timestamp":1104554339000},"page":"510-514","source":"Crossref","is-referenced-by-count":37,"title":["Malignant hyperthermia and related neuromuscular diseases: Caffeine contracture of the skinned muscle fibers"],"prefix":"10.1002","volume":"6","author":[{"given":"Akio","family":"Takagi","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Nobuhiko","family":"Sunohara","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Tadayuki","family":"Ishihara","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ikuya","family":"Nonaka","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hideo","family":"Sugita","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2004,10,13]]},"reference":[{"key":"e_1_2_1_2_2","first-page":"41","article-title":"Kinetics of radiocaffeine uptake and release in frog sartorius","volume":"138","author":"Bianchi CP","year":"1962","journal-title":"J Pharmacol Exp Ther"},{"key":"e_1_2_1_3_2","first-page":"44","article-title":"Etiology and pathophysiology of malignant hyperthermia","volume":"38","author":"Britt BA","year":"1979","journal-title":"Fed Proc"},{"key":"e_1_2_1_4_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(60)92690-8"},{"key":"e_1_2_1_5_2","first-page":"273","volume-title":"Malignant Hyperthermia","author":"Ellis FR","year":"1978"},{"key":"e_1_2_1_6_2","doi-asserted-by":"publisher","DOI":"10.1152\/physrev.1977.57.1.71"},{"key":"e_1_2_1_7_2","doi-asserted-by":"publisher","DOI":"10.1038\/newbio246216a0"},{"key":"e_1_2_1_8_2","doi-asserted-by":"crossref","first-page":"83","DOI":"10.2220\/biomedres.4.83","article-title":"Changes in the Ca\u2010induced Ca release mechanism in the sarcoplasmic reticulum of the muscle from a patient with malignant hyperthermia","volume":"4","author":"Endo M","year":"1983","journal-title":"Biomed Res"},{"key":"e_1_2_1_9_2","doi-asserted-by":"crossref","first-page":"395","DOI":"10.1097\/00000542-198011000-00007","article-title":"Malignant hyperthermia","volume":"53","author":"Gronert GA","year":"1978","journal-title":"Anesthesiology"},{"key":"e_1_2_1_10_2","first-page":"67","volume-title":"Malignant Hyperthermia","author":"Harriman DGF","year":"1978"},{"key":"e_1_2_1_11_2","first-page":"376","article-title":"Caffeine effects on radiocalcium movement in normal and denervated rat skeletal muscle","volume":"155","author":"Isaacson A","year":"1967","journal-title":"J Pharmacol Exp Ther"},{"key":"e_1_2_1_12_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(70)92069-6"},{"key":"e_1_2_1_13_2","first-page":"105","article-title":"Malignant hyperthermia: Diagnosis, treatment and investigation of a skeletal muscle lesion","volume":"38","author":"Nelson TE","year":"1979","journal-title":"Tex Rep Biol Med"},{"key":"e_1_2_1_14_2","doi-asserted-by":"publisher","DOI":"10.1093\/oxfordjournals.jbchem.a128887"},{"key":"e_1_2_1_15_2","doi-asserted-by":"publisher","DOI":"10.1007\/BF03007752"},{"key":"e_1_2_1_16_2","first-page":"3","volume-title":"Muscular Dystrophy","author":"Rowland LP","year":"1980"},{"key":"e_1_2_1_17_2","first-page":"127","article-title":"Histological and histochemical study on biopsied muscle of malignant hyperthermia and subclinical myopathy","volume":"16","author":"Sunohara N","year":"1980","journal-title":"Hiroshima J Anesth"},{"key":"e_1_2_1_18_2","doi-asserted-by":"publisher","DOI":"10.1002\/mus.880050511"},{"key":"e_1_2_1_19_2","doi-asserted-by":"publisher","DOI":"10.1002\/mus.880040104"},{"key":"e_1_2_1_20_2","doi-asserted-by":"publisher","DOI":"10.1212\/WNL.28.5.497"},{"key":"e_1_2_1_21_2","doi-asserted-by":"publisher","DOI":"10.1212\/WNL.28.5.447"}],"container-title":["Muscle &amp; 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