{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,23]],"date-time":"2026-10-23T03:02:29Z","timestamp":1792724549568,"version":"4.5.0"},"reference-count":35,"publisher":"Wiley","issue":"9","license":[{"start":{"date-parts":[[2004,10,13]],"date-time":"2004-10-13T00:00:00Z","timestamp":1097625600000},"content-version":"vor","delay-in-days":7652,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Muscle and Nerve"],"published-print":{"date-parts":[[1983,11]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Over 1,000 needle biopsies have been carried out at University College Hospital in London. Needle biopsy has been used by us for histochemical and electron microscopic examination of muscle during the diagnosis and treatment of neuropathic and myopathic disorders, for the diagnosis of mitochondrial myopathies, to study the course of recovery in polymyositis, and for investigations into muscle changes in systemic lupus erythematosus (SLE) and other autoimmune conditions. We have developed a microprocessor system for the measurement of muscle fiber areas, and needle biopsy specimens provide suitable material for such measurements. We have also used needle biopsy specimens for studies of protein turnover using stable isotopes and for trace metal and electrolyte analyses. Needle biopsy is safe and rapid. As the patient usually experiences only minimal discomfort and thereis no permanent scar, repeat biopsies are well tolerated allowing follow\u2010up studies after treatment.<\/jats:p>","DOI":"10.1002\/mus.880060910","type":"journal-article","created":{"date-parts":[[2005,1,1]],"date-time":"2005-01-01T04:41:03Z","timestamp":1104554463000},"page":"676-683","source":"Crossref","is-referenced-by-count":61,"title":["Occasional survey. Needle biopsy of skeletal muscle: A review of 10 years experience"],"prefix":"10.1002","volume":"6","author":[{"given":"R. H. T.","family":"Edwards","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"J. M.","family":"Round","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"D. A.","family":"Jones","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2004,10,13]]},"reference":[{"key":"e_1_2_1_2_2","doi-asserted-by":"publisher","DOI":"10.1016\/0022-510X(68)90134-2"},{"key":"e_1_2_1_3_2","doi-asserted-by":"publisher","DOI":"10.1016\/0020-708X(76)90143-5"},{"key":"e_1_2_1_4_2","doi-asserted-by":"publisher","DOI":"10.1007\/978-94-009-9756-1_13"},{"key":"e_1_2_1_5_2","first-page":"134","article-title":"Investigation of neuromuscular disorders","volume":"17","author":"Dubowitz V","year":"1983","journal-title":"J R Coll Physicians Lond"},{"key":"e_1_2_1_6_2","first-page":"98","volume-title":"Muscle Biopsy: A Modern Approach","author":"Dubowitz V","year":"1983"},{"key":"e_1_2_1_7_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-0404.1969.tb01238.x"},{"key":"e_1_2_1_8_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(71)80137-X"},{"key":"e_1_2_1_9_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(82)92635-6"},{"key":"e_1_2_1_10_2","first-page":"243","volume-title":"Recent Advances in Clinical Biochemistry","author":"Edwards RHT","year":"1981"},{"key":"e_1_2_1_11_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(75)91642-6"},{"key":"e_1_2_1_12_2","doi-asserted-by":"publisher","DOI":"10.1056\/NEJM198001313020504"},{"key":"e_1_2_1_13_2","doi-asserted-by":"publisher","DOI":"10.1152\/jappl.1982.53.6.1473"},{"key":"e_1_2_1_14_2","first-page":"107","volume-title":"Exercise Bio Energetics and Gas Exchange","author":"Faulkner JA","year":"1980"},{"key":"e_1_2_1_15_2","doi-asserted-by":"publisher","DOI":"10.1126\/science.644316"},{"key":"e_1_2_1_16_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1475-097X.1981.tb00888.x"},{"key":"e_1_2_1_17_2","first-page":"A75","article-title":"Assessment of mitochondrial function in needle biopsy samples","volume":"2","author":"Gohil K","year":"1981","journal-title":"Eur J Clin Invest"},{"key":"e_1_2_1_18_2","unstructured":"GohilK JonesDA RoundJM MillsK EdwardsRHT: Skeletal muscle mitochondrial function in patients with muscle pain.Clin Sci in press."},{"key":"e_1_2_1_19_2","doi-asserted-by":"publisher","DOI":"10.1172\/JCI105557"},{"key":"e_1_2_1_20_2","doi-asserted-by":"publisher","DOI":"10.1177\/036354657900700208"},{"key":"e_1_2_1_21_2","doi-asserted-by":"publisher","DOI":"10.3109\/00365517809108434"},{"key":"e_1_2_1_22_2","first-page":"917","article-title":"Muscle disease in systemic lupus erythematosus","volume":"8","author":"Isenberg DA","year":"1981","journal-title":"J Rheumatol"},{"key":"e_1_2_1_23_2","first-page":"5P","article-title":"Moppet, a rapid and accurate system for the measurement of muscle fibre crosssectional areas","volume":"305","author":"Jones DA","year":"1980","journal-title":"J Physiol (Lond)"},{"key":"e_1_2_1_24_2","doi-asserted-by":"publisher","DOI":"10.1002\/eji.1830060713"},{"key":"e_1_2_1_25_2","doi-asserted-by":"publisher","DOI":"10.1126\/science.7302583"},{"key":"e_1_2_1_26_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2990.1980.tb00205.x"},{"key":"e_1_2_1_27_2","first-page":"291","article-title":"A study of the contractility, biochemistry and morphology of an isolated preparation of human skeletal muscle","volume":"52","author":"Moulds RFW","year":"1977","journal-title":"Clin Sci Mol Med"},{"key":"e_1_2_1_28_2","doi-asserted-by":"publisher","DOI":"10.1002\/mus.880020509"},{"key":"e_1_2_1_29_2","doi-asserted-by":"publisher","DOI":"10.1038\/296165a0"},{"key":"e_1_2_1_30_2","doi-asserted-by":"publisher","DOI":"10.1136\/jcp.35.6.620"},{"key":"e_1_2_1_31_2","doi-asserted-by":"publisher","DOI":"10.1007\/BF01012026"},{"key":"e_1_2_1_32_2","first-page":"290","article-title":"Characterisation of polymyositic infiltrates using monoclonal antibodies to human leucocyte antigens","volume":"45","author":"Rowe DJ","year":"1981","journal-title":"Clin Exp Immunol"},{"key":"e_1_2_1_33_2","doi-asserted-by":"publisher","DOI":"10.1172\/JCI108262"},{"key":"e_1_2_1_34_2","doi-asserted-by":"publisher","DOI":"10.1002\/mus.880020309"},{"key":"e_1_2_1_35_2","first-page":"107","volume-title":"Research in Muscular Dystrophy Proceedings; IIIrd Symposium","author":"Sissons HA","year":"1965"},{"key":"e_1_2_1_36_2","doi-asserted-by":"publisher","DOI":"10.1042\/cs0620227"}],"container-title":["Muscle &amp; Nerve"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1002%2Fmus.880060910","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/mus.880060910","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,10,20]],"date-time":"2023-10-20T03:41:54Z","timestamp":1697773314000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/mus.880060910"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[1983,11]]},"references-count":35,"journal-issue":{"issue":"9","published-print":{"date-parts":[[1983,11]]}},"alternative-id":["10.1002\/mus.880060910"],"URL":"https:\/\/doi.org\/10.1002\/mus.880060910","archive":["Portico"],"relation":{},"ISSN":["0148-639X","1097-4598"],"issn-type":[{"value":"0148-639X","type":"print"},{"value":"1097-4598","type":"electronic"}],"subject":[],"published":{"date-parts":[[1983,11]]}}}