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In normal extracellular medium, the resting potential was reduced, but membrane conductance was not different from control. Excitability was reduced and the action potentials had no overshoot. On exposure to a 1\u2010m<jats:italic>M<\/jats:italic> potassium solution, with or without insulin, the cells depolarized to about \u221250 mV, and became inexcitable. Over the tested membrane potential range from \u2212120 to \u221240 mV, the slope conductance in the 1\u2010m<jats:italic>M<\/jats:italic> potassium solution was not different from that of control fibers in a 1\u2010m<jats:italic>M<\/jats:italic> potassium solution. In particular, the potassium component conductance was not reduced. Depolarized fibers could not be completely repolarized by returning to a 3.5\u2010m<jats:italic>M<\/jats:italic> potassium solution. An experimentally induced transient shift of the chloride equilibrium potential to a highly negative value caused stable repolarization. Paralysis could also be induced by replacement of extracellular chloride with an impermanent anion, a treatment which causes myotonia in healthy fibers. It was concluded that the basic defects are a reduced excitability and an increased sodium conductance, and that these defects are aggravated on reduction of the extracellular potassium concentration.<\/jats:p>","DOI":"10.1002\/mus.880070205","type":"journal-article","created":{"date-parts":[[2005,1,1]],"date-time":"2005-01-01T04:43:16Z","timestamp":1104554596000},"page":"110-120","source":"Crossref","is-referenced-by-count":158,"title":["Hypokalemic periodic paralysis: In vitro investigation of muscle fiber membrane parameters"],"prefix":"10.1002","volume":"7","author":[{"given":"Reinhardt","family":"R\u00fcdel","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Frank","family":"Lehmann\u2010Horn","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kenneth","family":"Ricker","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gerald","family":"K\u00fcther","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2004,10,13]]},"reference":[{"key":"e_1_2_1_2_2","doi-asserted-by":"publisher","DOI":"10.1113\/jphysiol.1977.sp011855"},{"key":"e_1_2_1_3_2","doi-asserted-by":"publisher","DOI":"10.1038\/214726a0"},{"key":"e_1_2_1_4_2","doi-asserted-by":"publisher","DOI":"10.1016\/0024-3205(69)90283-5"},{"key":"e_1_2_1_5_2","first-page":"147","volume-title":"Diseases of 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