{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,24]],"date-time":"2026-09-24T01:12:28Z","timestamp":1790212348370,"version":"4.1.0"},"reference-count":37,"publisher":"Wiley","issue":"7","license":[{"start":{"date-parts":[[2004,10,13]],"date-time":"2004-10-13T00:00:00Z","timestamp":1097625600000},"content-version":"vor","delay-in-days":7347,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Muscle and Nerve"],"published-print":{"date-parts":[[1984,9]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Pretreatment with glucagon relieved patients with McArdle disease from muscular symptoms during exercise and enhanced exercise performance, though it did not produce any improvement in patients with Tarui disease. The difference in glucagon effect between the two diseases was clearly demonstrated in the bicycle ergometer exercise tests. In addition, the semi\u2010ischemic forearm exercise tests performed after glucagon injection showed that increased lactate production was significantly incluced by exercise in McArdle disease, but it was not the case in Tarui disease. In McArdle disese, the augmentation in exercise\u2010induced lactate production was also observed after administration of glucose, or glucose plus insulin, but it was neither observed after administration of insulin alone nor after arginine or epinephrine administration. These findings suggest that the beneficial effect of glucagon in McArdle disease is due to the enhanced utilization of circulating glucose through the muscular glycolytic pathway realized in the coexistence of hyperglycemia and hyperinsulinemia.<\/jats:p>","DOI":"10.1002\/mus.880070706","type":"journal-article","created":{"date-parts":[[2005,1,1]],"date-time":"2005-01-01T04:27:40Z","timestamp":1104553660000},"page":"552-559","source":"Crossref","is-referenced-by-count":27,"title":["A comparative study on glucagon effect between mcardle disease and tarui disease"],"prefix":"10.1002","volume":"7","author":[{"given":"Ikuo","family":"Mineo","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Norio","family":"Kono","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Takao","family":"Shimizu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Seiichi","family":"Sumi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kyohei","family":"Nonaka","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Seiichiro","family":"Tarui","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2004,10,13]]},"reference":[{"key":"e_1_2_1_2_2","doi-asserted-by":"publisher","DOI":"10.1002\/mus.880030602"},{"key":"e_1_2_1_3_2","doi-asserted-by":"publisher","DOI":"10.1172\/JCI107645"},{"key":"e_1_2_1_4_2","doi-asserted-by":"crossref","first-page":"683","DOI":"10.1152\/jappl.1976.41.5.683","article-title":"Influence of glucose ingestion on fuel\u2010hormone response during prolonged exercise","volume":"41","author":"Ahlborg G","year":"1976","journal-title":"J Appl Physiol"},{"key":"e_1_2_1_5_2","doi-asserted-by":"publisher","DOI":"10.1136\/pgmj.53.617.161"},{"key":"e_1_2_1_6_2","doi-asserted-by":"publisher","DOI":"10.1042\/bj1460231"},{"key":"e_1_2_1_7_2","doi-asserted-by":"publisher","DOI":"10.1136\/jnnp.36.2.217"},{"key":"e_1_2_1_8_2","doi-asserted-by":"publisher","DOI":"10.1172\/JCI110399"},{"key":"e_1_2_1_9_2","first-page":"123","volume-title":"Advances in Neurology","author":"DiMauro S","year":"1977"},{"key":"e_1_2_1_10_2","first-page":"90","article-title":"Phosphoglycerate kinase deficiency: a new cause of recurrent myoglobinuria","volume":"10","author":"DiMauro S","year":"1981","journal-title":"Ann Neurol"},{"key":"e_1_2_1_11_2","doi-asserted-by":"publisher","DOI":"10.1126\/science.6262916"},{"key":"e_1_2_1_12_2","doi-asserted-by":"publisher","DOI":"10.1056\/NEJM196301172680306"},{"key":"e_1_2_1_13_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0002-9343(70)80003-1"},{"key":"e_1_2_1_14_2","doi-asserted-by":"publisher","DOI":"10.1056\/NEJM197511202932107"},{"key":"e_1_2_1_15_2","first-page":"1464","volume-title":"Methods of Enzymatic Analysis","author":"Gutmann I","year":"1974"},{"key":"e_1_2_1_16_2","doi-asserted-by":"publisher","DOI":"10.1136\/jnnp.27.3.186"},{"key":"e_1_2_1_17_2","doi-asserted-by":"publisher","DOI":"10.1016\/0009-8981(80)90013-3"},{"key":"e_1_2_1_18_2","doi-asserted-by":"publisher","DOI":"10.1016\/B978-0-12-152803-4.50010-5"},{"key":"e_1_2_1_19_2","doi-asserted-by":"publisher","DOI":"10.1016\/0006-291X(80)91535-1"},{"key":"e_1_2_1_20_2","first-page":"13","article-title":"Myopathy due to a defect in muscle glycogen breakdown","volume":"10","author":"McArdle B","year":"1951","journal-title":"Clin Sci"},{"key":"e_1_2_1_21_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(62)92145-1"},{"key":"e_1_2_1_22_2","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.45.6.791"},{"key":"e_1_2_1_23_2","doi-asserted-by":"publisher","DOI":"10.1016\/0002-9343(61)90075-4"},{"key":"e_1_2_1_24_2","doi-asserted-by":"crossref","first-page":"294","DOI":"10.1111\/j.0954-6820.1967.tb12635.x","article-title":"The second wind phenomenon in McArdle's syndrome","volume":"472","author":"Pernow BB","year":"1967","journal-title":"Acta Med Scand [Suppl]"},{"key":"e_1_2_1_25_2","doi-asserted-by":"publisher","DOI":"10.1056\/NEJM196608252750802"},{"key":"e_1_2_1_26_2","doi-asserted-by":"publisher","DOI":"10.1001\/archneur.1965.00470050089010"},{"key":"e_1_2_1_27_2","doi-asserted-by":"publisher","DOI":"10.1001\/archneur.1963.00460100013001"},{"key":"e_1_2_1_28_2","doi-asserted-by":"publisher","DOI":"10.1212\/WNL.16.1.93"},{"key":"e_1_2_1_29_2","doi-asserted-by":"publisher","DOI":"10.1172\/JCI110583"},{"key":"e_1_2_1_30_2","doi-asserted-by":"publisher","DOI":"10.1056\/NEJM196102022640504"},{"key":"e_1_2_1_31_2","doi-asserted-by":"publisher","DOI":"10.1172\/JCI103983"},{"key":"e_1_2_1_32_2","first-page":"179","article-title":"An approach to develop a new enzymatic method for determination of free fatty acid","volume":"4","author":"Takahashi Z","year":"1975","journal-title":"Preliminary report. 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