{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,6,27]],"date-time":"2025-06-27T10:35:52Z","timestamp":1751020552005},"reference-count":34,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2004,10,13]],"date-time":"2004-10-13T00:00:00Z","timestamp":1097625600000},"content-version":"vor","delay-in-days":7194,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Muscle and Nerve"],"published-print":{"date-parts":[[1985,2]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Mice were given 1 to 67 daily injections of whole plasma from a control subject and a patient with the Lambert\u2010Eaton myasthenic syndrome (LES), and the parameters of neuromuscular transmission in diaphragm muscles were studied in vitro. In animals that received 41 to 59 injections of LES plasma, mean quantum content of the endplate potentials, as measured under the conditions of low [Ca<jats:sup>2+<\/jats:sup>]<jats:sub>0<\/jats:sub> (1.2 m<jats:italic>M<\/jats:italic>) and high [Mg<jats:sup>2+<\/jats:sup>]<jats:sub>0<\/jats:sub> (10 m<jats:italic>M<\/jats:italic>), was reduced to 30% of the control, or 40% of the value found in normal untreated mice. When [K<jats:sup>+<\/jats:sup>]<jats:sub>0<\/jats:sub> was elevated from 5 m<jats:italic>M<\/jats:italic> to 17.5 m<jats:italic>M<\/jats:italic>, the frequency of spontaneous miniature endplate potentials increased by a factor of 98 and 105 respectively in the control and normal mice but only 39 times in the LES plasma recipients. Despite these presynaptic abnormalities, no evidence of postsynaptic deficit, nerve conduction failure, or inability of the muscle fibers to produce normal action potentials was found. These electrophysiologic features in mice thus represent a reproduction of the human condition, supporting the concept of humoral involvement in the pathophysiology of LES. Passively transferred LES in mice is a faithful animal model of the human disease which will be useful in exploring the molecular basis of the presynaptic impairment.<\/jats:p>","DOI":"10.1002\/mus.880080213","type":"journal-article","created":{"date-parts":[[2005,1,1]],"date-time":"2005-01-01T04:50:20Z","timestamp":1104555020000},"page":"162-172","source":"Crossref","is-referenced-by-count":46,"title":["Passive transfer of the Lambert\u2010Eaton myasthenic syndrome: Neuromuscular transmission in mice injected with plasma"],"prefix":"10.1002","volume":"8","author":[{"given":"Yong I.","family":"Kim","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2004,10,13]]},"reference":[{"key":"e_1_2_1_2_2","doi-asserted-by":"publisher","DOI":"10.1136\/jnnp.37.11.1214"},{"key":"e_1_2_1_3_2","first-page":"2346","article-title":"P\u00e9cot\u2010Dechavassine M: V\u00e9sicules synaptiques et poches au niveau des \u2018zones actives\u2019 de la jonction neuromusculaire","volume":"271","author":"Couteaux R","year":"1970","journal-title":"CR Acad Sci [D] (Paris)"},{"key":"e_1_2_1_4_2","doi-asserted-by":"publisher","DOI":"10.1113\/jphysiol.1980.sp013145"},{"key":"e_1_2_1_5_2","doi-asserted-by":"publisher","DOI":"10.1113\/jphysiol.1954.sp005129"},{"key":"e_1_2_1_6_2","doi-asserted-by":"publisher","DOI":"10.1146\/annurev.ne.04.030181.001211"},{"key":"e_1_2_1_7_2","doi-asserted-by":"publisher","DOI":"10.1001\/jama.1957.02970480021005"},{"key":"e_1_2_1_8_2","first-page":"689","article-title":"Detailed analysis of neuromuscular transmission in a patient with the myasthenic syndrome sometimes associated with bronchogenic carcinoma","volume":"43","author":"Elmqvist D","year":"1968","journal-title":"Mayo Clin Proc"},{"key":"e_1_2_1_9_2","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.80.24.7636"},{"key":"e_1_2_1_10_2","doi-asserted-by":"publisher","DOI":"10.1002\/mus.880050905"},{"key":"e_1_2_1_11_2","doi-asserted-by":"publisher","DOI":"10.1016\/0002-9343(72)90179-9"},{"key":"e_1_2_1_12_2","doi-asserted-by":"publisher","DOI":"10.1016\/0013-4694(67)90118-6"},{"key":"e_1_2_1_13_2","doi-asserted-by":"publisher","DOI":"10.1212\/WNL.30.7.760"},{"key":"e_1_2_1_14_2","doi-asserted-by":"publisher","DOI":"10.1098\/rspb.1967.0011"},{"key":"e_1_2_1_15_2","doi-asserted-by":"publisher","DOI":"10.1113\/jphysiol.1957.sp005811"},{"key":"e_1_2_1_16_2","doi-asserted-by":"publisher","DOI":"10.1113\/jphysiol.1978.sp012133"},{"key":"e_1_2_1_17_2","doi-asserted-by":"publisher","DOI":"10.1055\/s-2008-1041649"},{"key":"e_1_2_1_18_2","first-page":"199","article-title":"Passive transfer of the Lambert\u2010Eaton myasthenic syndrome to mice using whole plasma and immunoglobulin fractions","volume":"10","author":"Kim YI","year":"1984","journal-title":"Soc Neurosci Abstr"},{"key":"e_1_2_1_19_2","doi-asserted-by":"publisher","DOI":"10.1016\/0014-4886(81)90041-8"},{"key":"e_1_2_1_20_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1749-6632.1971.tb30750.x"},{"key":"e_1_2_1_21_2","first-page":"67","volume-title":"The Remote Effects of Cancer on the Nervous System","author":"Lambert EH","year":"1965"},{"key":"e_1_2_1_22_2","first-page":"362","volume-title":"Myasthenia Gravis","author":"Lambert EH","year":"1961"},{"key":"e_1_2_1_23_2","doi-asserted-by":"publisher","DOI":"10.1113\/jphysiol.1983.sp014943"},{"key":"e_1_2_1_24_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(81)90474-8"},{"key":"e_1_2_1_25_2","first-page":"S21","article-title":"Autoimmunity in the Lambert\u2010Eaton invasthenic syndrome","volume":"5","author":"Lennon VA","year":"1982","journal-title":"Muscle Nerve"},{"key":"e_1_2_1_26_2","doi-asserted-by":"publisher","DOI":"10.1113\/jphysiol.1978.sp012438"},{"key":"e_1_2_1_27_2","doi-asserted-by":"publisher","DOI":"10.1016\/0010-468X(83)90078-8"},{"key":"e_1_2_1_28_2","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.79.7.2415"},{"key":"e_1_2_1_29_2","doi-asserted-by":"publisher","DOI":"10.1152\/physrev.1966.46.1.51"},{"key":"e_1_2_1_30_2","first-page":"S17","article-title":"Lambert\u2010Eaton myasthenic syndrome: electrophysiological evidence for a humoral factor","volume":"5","author":"Newsom\u2010Davis J","year":"1982","journal-title":"Muscle Nerve"},{"key":"e_1_2_1_31_2","doi-asserted-by":"publisher","DOI":"10.1136\/jnnp.43.11.978"},{"key":"e_1_2_1_32_2","doi-asserted-by":"publisher","DOI":"10.1136\/jnnp.41.8.746"},{"key":"e_1_2_1_33_2","doi-asserted-by":"publisher","DOI":"10.1126\/science.1179220"},{"key":"e_1_2_1_34_2","doi-asserted-by":"publisher","DOI":"10.1152\/physrev.1980.60.3.756"},{"key":"e_1_2_1_35_2","doi-asserted-by":"crossref","first-page":"C157","DOI":"10.1152\/ajpcell.1977.233.5.C157","article-title":"Estimates of quantal\u2010release and binomial statistical\u2010release parameters at rat neuromuscular junction","volume":"233","author":"Wilson DF","year":"1977","journal-title":"Am J Physiol"}],"container-title":["Muscle &amp; Nerve"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1002%2Fmus.880080213","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/mus.880080213","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,10,21]],"date-time":"2023-10-21T05:12:22Z","timestamp":1697865142000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/mus.880080213"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[1985,2]]},"references-count":34,"journal-issue":{"issue":"2","published-print":{"date-parts":[[1985,2]]}},"alternative-id":["10.1002\/mus.880080213"],"URL":"https:\/\/doi.org\/10.1002\/mus.880080213","archive":["Portico"],"relation":{},"ISSN":["0148-639X","1097-4598"],"issn-type":[{"value":"0148-639X","type":"print"},{"value":"1097-4598","type":"electronic"}],"subject":[],"published":{"date-parts":[[1985,2]]}}}