{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,9,10]],"date-time":"2025-09-10T22:21:29Z","timestamp":1757542889941},"reference-count":37,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2004,10,13]],"date-time":"2004-10-13T00:00:00Z","timestamp":1097625600000},"content-version":"vor","delay-in-days":7166,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Muscle and Nerve"],"published-print":{"date-parts":[[1985,3]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>In polymyositis (PM), neither the precise target nor the mechanism of the attack against skeletal muscle have yet been defined. In this study, we report evidence of a pathologic process involving a membrane component of muscle, acetylcholine receptors (AChRs). Our results show that PM patients have significantly reduced AChRs at neuromuscular junctions, averaging 55% below control values (<jats:italic>P<\/jats:italic> &lt; 0.001). Incubation of cultured mammalian muscle cells with sera from PM patients significantly reduced (<jats:italic>P<\/jats:italic> &lt; 0.005) the number of surface AChRs and increased their rate of degradation in 7\/8 cases (<jats:italic>P<\/jats:italic> &lt; 0.005). Similar effects were produced by purified lgG from PM patients. These results demonstrate the presence in PM patients of circulating lgG with functional effects on a component of the surface membrane of skeletal muscle. They suggest that PM and myasthenia gravis may have important features in common.<\/jats:p>","DOI":"10.1002\/mus.880080309","type":"journal-article","created":{"date-parts":[[2005,1,1]],"date-time":"2005-01-01T04:50:40Z","timestamp":1104555040000},"page":"233-239","source":"Crossref","is-referenced-by-count":10,"title":["Polymyositis: Reduction of acetylcholine receptors in skeletal muscle"],"prefix":"10.1002","volume":"8","author":[{"given":"Alan","family":"Pestronk","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Daniel B.","family":"Drachman","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2004,10,13]]},"reference":[{"key":"e_1_2_1_2_2","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.74.5.2130"},{"key":"e_1_2_1_3_2","first-page":"2381","article-title":"The role of acetylcholine receptor antibodies in myasthenia gravis","volume":"38","author":"Appel SH","year":"1979","journal-title":"Fed Proc"},{"key":"e_1_2_1_4_2","doi-asserted-by":"publisher","DOI":"10.1097\/00005792-197707000-00001"},{"key":"e_1_2_1_5_2","doi-asserted-by":"publisher","DOI":"10.1007\/BF00312989"},{"key":"e_1_2_1_6_2","first-page":"525","volume-title":"Disorders of Voluntary Muscle","author":"Currie S","year":"1981"},{"key":"e_1_2_1_7_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1749-6632.1981.tb33745.x"},{"key":"e_1_2_1_8_2","doi-asserted-by":"publisher","DOI":"10.1083\/jcb.65.2.335"},{"key":"e_1_2_1_9_2","first-page":"335","article-title":"Turnover of acetylcholine receptors in skeletal muscle","volume":"65","author":"Devreotes PN","year":"1975","journal-title":"Cold Spring Harbor Symp Quant Biol"},{"key":"e_1_2_1_10_2","first-page":"60","article-title":"Tanned\u2010cell hemagglutination test for detection of antibodies in sera of patients with myasthenia gravis","volume":"63","author":"Djanian AY","year":"1964","journal-title":"J Lab Clin Med"},{"key":"e_1_2_1_11_2","doi-asserted-by":"publisher","DOI":"10.1056\/NEJM197801192980305"},{"key":"e_1_2_1_12_2","doi-asserted-by":"publisher","DOI":"10.1146\/annurev.ne.04.030181.001211"},{"key":"e_1_2_1_13_2","doi-asserted-by":"publisher","DOI":"10.1056\/NEJM198209233071301"},{"key":"e_1_2_1_14_2","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.75.7.3422"},{"key":"e_1_2_1_15_2","first-page":"132","volume-title":"Recent Advances in Myology","author":"Engel AG","year":"1975"},{"key":"e_1_2_1_16_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1749-6632.1971.tb30741.x"},{"key":"e_1_2_1_17_2","doi-asserted-by":"publisher","DOI":"10.1016\/0198-8859(81)90055-0"},{"key":"e_1_2_1_18_2","first-page":"51","volume-title":"Handbook of Clinical Neurology, vol 41, Diseases of Muscle, Part II","author":"Hudgson P","year":"1979"},{"key":"e_1_2_1_19_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1749-6632.1971.tb30742.x"},{"key":"e_1_2_1_20_2","doi-asserted-by":"publisher","DOI":"10.1126\/science.831257"},{"key":"e_1_2_1_21_2","doi-asserted-by":"publisher","DOI":"10.1212\/WNL.26.11.1054"},{"key":"e_1_2_1_22_2","doi-asserted-by":"publisher","DOI":"10.1038\/304177a0"},{"key":"e_1_2_1_23_2","doi-asserted-by":"publisher","DOI":"10.1038\/264074a0"},{"key":"e_1_2_1_24_2","doi-asserted-by":"publisher","DOI":"10.1016\/0022-510X(73)90033-6"},{"key":"e_1_2_1_25_2","doi-asserted-by":"publisher","DOI":"10.1001\/jama.237.17.1842"},{"key":"e_1_2_1_26_2","first-page":"449","article-title":"Histocompatibility antigens and human disease","volume":"18","author":"Oliver RTD","year":"1977","journal-title":"Br J Hosp Med"},{"key":"e_1_2_1_27_2","doi-asserted-by":"publisher","DOI":"10.1002\/1529-0131(195904)2:2<127::AID-ART1780020205>3.0.CO;2-M"},{"key":"e_1_2_1_28_2","doi-asserted-by":"publisher","DOI":"10.7326\/0003-4819-59-6-827"},{"key":"e_1_2_1_29_2","doi-asserted-by":"publisher","DOI":"10.1002\/mus.880080311"},{"key":"e_1_2_1_30_2","unstructured":"ReichlinM ArnettF: Multiplicity of antibodies in myositis sera.Arthritis Rheum in press."},{"key":"e_1_2_1_31_2","first-page":"417","article-title":"Giant cell arteritis: Review of 35 cases","volume":"28","author":"Russell RWR","year":"1959","journal-title":"QJ Med"},{"key":"e_1_2_1_32_2","doi-asserted-by":"publisher","DOI":"10.1001\/archneur.1962.00450240006002"},{"key":"e_1_2_1_33_2","first-page":"149","volume-title":"Single Fiber Electromyography","author":"St\u00e5lberg E","year":"1979"},{"key":"e_1_2_1_34_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1749-6632.1965.tb18999.x"},{"key":"e_1_2_1_35_2","doi-asserted-by":"publisher","DOI":"10.1016\/0022-510X(78)90060-6"},{"key":"e_1_2_1_36_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1749-6632.1966.tb45461.x"},{"key":"e_1_2_1_37_2","doi-asserted-by":"publisher","DOI":"10.1016\/B978-0-12-427150-0.50032-2"},{"key":"e_1_2_1_38_2","doi-asserted-by":"publisher","DOI":"10.1097\/00005072-196207000-00001"}],"container-title":["Muscle &amp; 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