{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,2]],"date-time":"2026-07-02T13:10:14Z","timestamp":1782997814458,"version":"3.54.5"},"reference-count":40,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2004,10,13]],"date-time":"2004-10-13T00:00:00Z","timestamp":1097625600000},"content-version":"vor","delay-in-days":7166,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Muscle and Nerve"],"published-print":{"date-parts":[[1985,3]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>We measured the number of acetylcholine receptors (AChRs) at neuromuscular junctions (NMJs) in motor point biopsies from 76 patients with myasthenia gravis (MG) and 49 control subjects, using an \u03b1\u2010bungarotoxin binding technique. The mean number of AChRs\/NMJ was significantly lower (<jats:italic>P<\/jats:italic> &lt; 0.001) in muscles of MG patients (deltoid 0.7 \u00b1 0.1 \u00d7 10<jats:sup>7<\/jats:sup>) than in controls (2.1 \u00d7 0.2 \u00d7 10<jats:sup>7<\/jats:sup>). None of the control muscles had fewer than 0.9 \u00d7 10<jats:sup>7<\/jats:sup> AChRs\/NMJ, and 75% of MG muscles were below that level. Conversely, 88% of controls had 1.5% \u00d7 10<jats:sup>7<\/jats:sup> or more AChRs\/NMJ, whereas only one of the MG muscles (2.5%) was at or above that level. The reduction of AChRs correlated approximately with the clinical severity of weakness (<jats:italic>P<\/jats:italic> &lt; 0.02). Patients with focal weakness had reduced numbers of AChRs\/NMJ in clinically strong muscles. The only other condition in which junctional AChRs were reduced was polyositis. These findings in a large sample of patients confirm the reduction of junctional AChRs in MG, the relationship of available junctional AChRs to clinical manifestations, and the systemic nature of the disorder even in cases with focal weakness. Measurement of AChRs can be useful diagnostically in situations where other tests are inconclusive.<\/jats:p>","DOI":"10.1002\/mus.880080311","type":"journal-article","created":{"date-parts":[[2005,1,1]],"date-time":"2005-01-01T04:50:40Z","timestamp":1104555040000},"page":"245-251","source":"Crossref","is-referenced-by-count":61,"title":["Measurement of junctional acetylcholine receptors in myasthenia gravis: Clinical correlates"],"prefix":"10.1002","volume":"8","author":[{"given":"Alan","family":"Pestronk","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Daniel B.","family":"Drachman","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Steven G.","family":"Self","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2004,10,13]]},"reference":[{"key":"e_1_2_1_2_2","doi-asserted-by":"publisher","DOI":"10.1016\/0014-4886(76)90179-5"},{"key":"e_1_2_1_3_2","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.69.1.147"},{"key":"e_1_2_1_4_2","volume-title":"The Innervation of Muscle. A Biopsy Study","author":"Co\u00e9rs C","year":"1959"},{"key":"e_1_2_1_5_2","doi-asserted-by":"publisher","DOI":"10.1212\/WNL.31.11.1440"},{"key":"e_1_2_1_6_2","doi-asserted-by":"publisher","DOI":"10.1056\/NEJM197711242972102"},{"key":"e_1_2_1_7_2","doi-asserted-by":"publisher","DOI":"10.1038\/179156a0"},{"key":"e_1_2_1_8_2","first-page":"104","volume-title":"Handbook of Neurology","author":"Desmedt JE","year":"1970"},{"key":"e_1_2_1_9_2","doi-asserted-by":"publisher","DOI":"10.1056\/NEJM198209233071301"},{"key":"e_1_2_1_10_2","doi-asserted-by":"publisher","DOI":"10.1214\/aos\/1176344552"},{"key":"e_1_2_1_11_2","doi-asserted-by":"publisher","DOI":"10.1080\/01621459.1983.10477973"},{"key":"e_1_2_1_12_2","first-page":"111","volume-title":"Current Topics in Nerve and Muscle Research","author":"Engel AG","year":"1979"},{"key":"e_1_2_1_13_2","doi-asserted-by":"publisher","DOI":"10.1085\/jgp.64.4.468"},{"key":"e_1_2_1_14_2","doi-asserted-by":"publisher","DOI":"10.1083\/jcb.76.1.237"},{"key":"e_1_2_1_15_2","doi-asserted-by":"publisher","DOI":"10.1126\/science.182.4109.293"},{"key":"e_1_2_1_16_2","doi-asserted-by":"publisher","DOI":"10.1126\/science.176.4031.189"},{"key":"e_1_2_1_17_2","doi-asserted-by":"publisher","DOI":"10.1001\/archneur.1978.00500260035009"},{"key":"e_1_2_1_18_2","first-page":"92","volume-title":"Plasmapheresis and the Immunobiology of Myasthenia Gravis, chap","author":"Heilbronn E","year":"1979"},{"key":"e_1_2_1_19_2","doi-asserted-by":"publisher","DOI":"10.1212\/WNL.26.5.410"},{"key":"e_1_2_1_20_2","doi-asserted-by":"publisher","DOI":"10.1093\/brain\/101.2.345"},{"key":"e_1_2_1_21_2","doi-asserted-by":"publisher","DOI":"10.1126\/science.850793"},{"key":"e_1_2_1_22_2","doi-asserted-by":"publisher","DOI":"10.1177\/12.3.219"},{"key":"e_1_2_1_23_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1749-6632.1981.tb33724.x"},{"key":"e_1_2_1_24_2","doi-asserted-by":"publisher","DOI":"10.1212\/WNL.28.2.130"},{"key":"e_1_2_1_25_2","doi-asserted-by":"publisher","DOI":"10.1212\/WNL.26.11.1054"},{"key":"e_1_2_1_26_2","volume-title":"Myasthenia Gravis","author":"Lisak RP","year":"1982"},{"key":"e_1_2_1_27_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1749-6632.1976.tb47724.x"},{"key":"e_1_2_1_28_2","doi-asserted-by":"crossref","first-page":"6300","DOI":"10.1016\/S0021-9258(18)50365-3","article-title":"Acetylcholine receptor degradation in adult rat diaphragms in organ culture and the effect of anti\u2010acetylcholine receptor antibodies","volume":"254","author":"Merlie JP","year":"1979","journal-title":"J Biol Chem"},{"key":"e_1_2_1_29_2","doi-asserted-by":"publisher","DOI":"10.1002\/mus.880080309"},{"key":"e_1_2_1_30_2","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.73.12.4584"},{"key":"e_1_2_1_31_2","doi-asserted-by":"publisher","DOI":"10.1038\/274068a0"},{"key":"e_1_2_1_32_2","first-page":"411","volume-title":"Myasthenia Gravis","author":"Rowland LH","year":"1961"},{"key":"e_1_2_1_33_2","doi-asserted-by":"publisher","DOI":"10.1212\/WNL.28.8.804"},{"key":"e_1_2_1_34_2","first-page":"585","volume-title":"Disorders of Voluntary Muscle","author":"Simpson JA","year":"1981"},{"key":"e_1_2_1_35_2","doi-asserted-by":"publisher","DOI":"10.1126\/science.663610"},{"key":"e_1_2_1_36_2","doi-asserted-by":"publisher","DOI":"10.1113\/jphysiol.1981.sp013679"},{"key":"e_1_2_1_37_2","doi-asserted-by":"publisher","DOI":"10.1126\/science.1179220"},{"key":"e_1_2_1_38_2","doi-asserted-by":"publisher","DOI":"10.1212\/WNL.29.5.654"},{"key":"e_1_2_1_39_2","doi-asserted-by":"publisher","DOI":"10.1212\/WNL.30.11.1203"},{"key":"e_1_2_1_40_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1749-6632.1971.tb30747.x"},{"key":"e_1_2_1_41_2","doi-asserted-by":"publisher","DOI":"10.1097\/00005072-196207000-00001"}],"container-title":["Muscle &amp; Nerve"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1002%2Fmus.880080311","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/mus.880080311","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,10,21]],"date-time":"2023-10-21T00:51:31Z","timestamp":1697849491000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/mus.880080311"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[1985,3]]},"references-count":40,"journal-issue":{"issue":"3","published-print":{"date-parts":[[1985,3]]}},"alternative-id":["10.1002\/mus.880080311"],"URL":"https:\/\/doi.org\/10.1002\/mus.880080311","archive":["Portico"],"relation":{},"ISSN":["0148-639X","1097-4598"],"issn-type":[{"value":"0148-639X","type":"print"},{"value":"1097-4598","type":"electronic"}],"subject":[],"published":{"date-parts":[[1985,3]]}}}