{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,11]],"date-time":"2026-04-11T17:41:23Z","timestamp":1775929283058,"version":"3.50.1"},"reference-count":22,"publisher":"Wiley","issue":"5","license":[{"start":{"date-parts":[[2004,10,13]],"date-time":"2004-10-13T00:00:00Z","timestamp":1097625600000},"content-version":"vor","delay-in-days":7074,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Muscle and Nerve"],"published-print":{"date-parts":[[1985,6]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Ca<jats:sup>2+<\/jats:sup> selective microlectrodes have been used to determine the free myoplasmic [Ca<jats:sup>2+<\/jats:sup>] in human skeletal muscle obtained from patients who had developed early signs associated with malignant hyperthermia (MH) during anesthesia. Intercostal muscle biopsies were performed under local anesthesia in four MH patients 15 days to 4 months after developing the MH crisis and in three control subjects. We used only microelectrodes that showed a Nernstian response between pCa<jats:sub>3<\/jats:sub> and pCa<jats:sub>7<\/jats:sub> (30.5 mV per decade at 37\u00b0C). Membrane resting potential (<jats:italic>V<jats:sub>m<\/jats:sub><\/jats:italic>) and calcium potential (<jats:italic>V<jats:sub>Ca<\/jats:sub><\/jats:italic>) were obtained from superficial fibers. The free cytosolic [Ca<jats:sup>2+<\/jats:sup>] was 0.39 \u00b1 0.1 m\u0308<jats:italic>M<\/jats:italic> (mean \u00b1 SEM, <jats:italic>n<\/jats:italic> = 18) in muscle fibers obtained from malignant hyperthermic patients, whereas in control subjects it was 0.11 \u00b1 0.02 m\u0308<jats:italic>M<\/jats:italic> (<jats:italic>n<\/jats:italic> = 10). These results suggest that this syndrome might be related to an abnormally high myoplasmic free resting calcium concentration, probably due to a defective function of the plasma membrane or the sarcoplasmic reticulum.<\/jats:p>","DOI":"10.1002\/mus.880080502","type":"journal-article","created":{"date-parts":[[2005,1,1]],"date-time":"2005-01-01T08:18:04Z","timestamp":1104567484000},"page":"355-358","source":"Crossref","is-referenced-by-count":113,"title":["Intracellular ionized calcium concentration in muscles from humans with malignant hyperthermia"],"prefix":"10.1002","volume":"8","author":[{"given":"Jos\u00e9 R.","family":"L\u00f3pez","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Lorenzo","family":"Alamo","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Carlo","family":"Caputo","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jaime","family":"Wikinski","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"David","family":"Ledezma","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2004,10,13]]},"reference":[{"key":"e_1_2_1_2_2","doi-asserted-by":"publisher","DOI":"10.1113\/jphysiol.1981.sp013762"},{"key":"e_1_2_1_3_2","doi-asserted-by":"publisher","DOI":"10.1113\/jphysiol.1969.sp008703"},{"key":"e_1_2_1_4_2","doi-asserted-by":"publisher","DOI":"10.1007\/BFb0034293"},{"key":"e_1_2_1_5_2","first-page":"44","article-title":"Etiology and pathophysiology of malignant hyperthermia","volume":"38","author":"Britt BA","year":"1979","journal-title":"Fed Proc"},{"key":"e_1_2_1_6_2","doi-asserted-by":"publisher","DOI":"10.1097\/00000542-197503000-00010"},{"key":"e_1_2_1_7_2","first-page":"63","volume-title":"Malignant Hyperthermia, Current Concepts","author":"Britt BA","year":"1977"},{"key":"e_1_2_1_8_2","doi-asserted-by":"publisher","DOI":"10.1007\/BF03005788"},{"key":"e_1_2_1_9_2","doi-asserted-by":"publisher","DOI":"10.1007\/BF03015252"},{"key":"e_1_2_1_10_2","doi-asserted-by":"publisher","DOI":"10.1038\/274390a0"},{"key":"e_1_2_1_11_2","doi-asserted-by":"publisher","DOI":"10.1016\/0005-2736(83)90500-X"},{"key":"e_1_2_1_12_2","doi-asserted-by":"publisher","DOI":"10.1002\/mus.880020610"},{"key":"e_1_2_1_13_2","first-page":"91","article-title":"Mechanical properties of normal and malignant hyperthermia susceptible porcine muscle; effects of halothane and other drugs","volume":"213","author":"Gallant EM","year":"1980","journal-title":"J Pharmacol Exp Ther"},{"key":"e_1_2_1_14_2","doi-asserted-by":"publisher","DOI":"10.1097\/00000542-198011000-00007"},{"key":"e_1_2_1_15_2","doi-asserted-by":"publisher","DOI":"10.1002\/mus.880020303"},{"key":"e_1_2_1_16_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0006-3495(83)84316-1"},{"key":"e_1_2_1_17_2","first-page":"48a","article-title":"Measurements of free [Ca2+]i in human malignant hyperthermic muscles","volume":"45","author":"L\u00f3pez JR","year":"1984","journal-title":"Biophys J"},{"key":"e_1_2_1_18_2","doi-asserted-by":"publisher","DOI":"10.1016\/0014-5793(83)80739-X"},{"key":"e_1_2_1_19_2","doi-asserted-by":"publisher","DOI":"10.1016\/0014-5793(84)80845-5"},{"key":"e_1_2_1_20_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1749-6632.1978.tb41935.x"},{"key":"e_1_2_1_21_2","first-page":"321","article-title":"Calcium movements in relation to muscle contraction","volume":"22","author":"Taylor SR","year":"1979","journal-title":"Proc West Pharmacol Soc"},{"key":"e_1_2_1_22_2","doi-asserted-by":"publisher","DOI":"10.1016\/0005-2736(80)90205-9"},{"key":"e_1_2_1_23_2","doi-asserted-by":"publisher","DOI":"10.1126\/science.959824"}],"container-title":["Muscle &amp; 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