{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2024,6,17]],"date-time":"2024-06-17T20:39:26Z","timestamp":1718656766961},"reference-count":30,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2004,10,13]],"date-time":"2004-10-13T00:00:00Z","timestamp":1097625600000},"content-version":"vor","delay-in-days":6829,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Muscle and Nerve"],"published-print":{"date-parts":[[1986,2]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>A possible relationship between muscle cell injury or deterioration and enhanced halothane sensitivity was studied by monitoring mechanical responses of skeletal muscles from normal pigs and pigs susceptible to malignant hyperthermia (MH). Increased time postbiopsy and decreased maximum control tetanic tension both correlated significently with enhanced sensitivity to halothane. In both normal and MHsusceptible (MHS) muscles, greater halothane sensitivity was observed in cut cell than in intact cell bundles and in low tetanic tension as compared to high tension preparations. Subsequent to halothane exposure, twitches of high tension (\u2265 1.75 kg \u00b7 cm <jats:sup>\u22122<\/jats:sup>) intact bundles of both normal and MHS muscles were potentiated. Tetani of normal intact bundles were not altered, whereas those of MHS bundles were depressed after halothane exposure. Control twitch\u2010to\u2010tetanus ratios (twitch ratios) were higher in MHS (0.23) than in normal (0.12) intact bundles. According to discriminant analysis, the best distinction between normal and MHS muscles, either cut or intact, was obtained by comparing halothane\u2010induced changes in tetanic tension and control twitch ratios.<\/jats:p>","DOI":"10.1002\/mus.880090211","type":"journal-article","created":{"date-parts":[[2005,1,1]],"date-time":"2005-01-01T09:06:02Z","timestamp":1104570362000},"page":"174-184","source":"Crossref","is-referenced-by-count":32,"title":["Porcine malignant hyperthermia: Cell injury enhances halothane sensitivity of biopsies"],"prefix":"10.1002","volume":"9","author":[{"given":"Esther M.","family":"Gallant","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Thomas F.","family":"Fletcher","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Virginia M.","family":"Goettl","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"William E.","family":"Rempel","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2004,10,13]]},"reference":[{"key":"e_1_2_1_2_2","first-page":"509","volume-title":"Second International Symposium on Malignant Hyperthemia","author":"Anderson IL","year":"1978"},{"key":"e_1_2_1_3_2","doi-asserted-by":"publisher","DOI":"10.1007\/BF03006840"},{"key":"e_1_2_1_4_2","doi-asserted-by":"publisher","DOI":"10.1007\/BF03007740"},{"key":"e_1_2_1_5_2","doi-asserted-by":"publisher","DOI":"10.1007\/BF03015252"},{"key":"e_1_2_1_6_2","first-page":"213","article-title":"Mechanical activation and electrophysiological properties of intercostal muscle fibersr from malignant\u2010hyperthermia\u2010susceptible (MHS) pigs","volume":"3","author":"Bryant SH","year":"1977","journal-title":"Soc Neurosci"},{"key":"e_1_2_1_7_2","doi-asserted-by":"publisher","DOI":"10.1152\/physrev.1972.52.1.129"},{"key":"e_1_2_1_8_2","doi-asserted-by":"publisher","DOI":"10.1016\/0024-3205(67)90103-8"},{"key":"e_1_2_1_9_2","doi-asserted-by":"publisher","DOI":"10.1152\/ajpcell.1982.243.1.C66"},{"key":"e_1_2_1_10_2","doi-asserted-by":"publisher","DOI":"10.1007\/BF01960413"},{"key":"e_1_2_1_11_2","doi-asserted-by":"publisher","DOI":"10.1002\/mus.880020610"},{"key":"e_1_2_1_12_2","first-page":"91","article-title":"Mechanical properties of normal and malignant hyperthermia. Susceptible porcine muscle: effects of halothane and other drugs","volume":"213","author":"Gallant EM","year":"1980","journal-title":"J Pharmacol Exp Ther"},{"key":"e_1_2_1_13_2","first-page":"292a","article-title":"Halothane alters tetani of skeletal muscles from pigs susceptible to malignant hyperthermia","volume":"47","author":"Gallant EM","year":"1985","journal-title":"Biophys J"},{"key":"e_1_2_1_14_2","doi-asserted-by":"publisher","DOI":"10.1016\/0304-3940(82)90149-5"},{"key":"e_1_2_1_15_2","doi-asserted-by":"publisher","DOI":"10.1113\/jphysiol.1966.sp007909"},{"key":"e_1_2_1_16_2","first-page":"367","article-title":"Muscle contractures and adenosine triphosphate depletion in porcine malignant hyperthermia","volume":"58","author":"Gronert GA","year":"1979","journal-title":"Anesth Analg (Cleve)"},{"key":"e_1_2_1_17_2","doi-asserted-by":"publisher","DOI":"10.1097\/00000542-198011000-00007"},{"key":"e_1_2_1_18_2","doi-asserted-by":"publisher","DOI":"10.1016\/0014-2999(79)90010-4"},{"key":"e_1_2_1_19_2","doi-asserted-by":"publisher","DOI":"10.1007\/BF03006711"},{"key":"e_1_2_1_20_2","doi-asserted-by":"publisher","DOI":"10.1126\/science.6974399"},{"key":"e_1_2_1_21_2","first-page":"49","volume-title":"Second International Symposium on Malignant Hyperthermia","author":"Moulds RFW","year":"1978"},{"key":"e_1_2_1_22_2","doi-asserted-by":"publisher","DOI":"10.1097\/00000542-197507000-00006"},{"key":"e_1_2_1_23_2","doi-asserted-by":"publisher","DOI":"10.1093\/bja\/49.2.169"},{"key":"e_1_2_1_24_2","doi-asserted-by":"publisher","DOI":"10.1097\/00000542-197503000-00011"},{"key":"e_1_2_1_25_2","doi-asserted-by":"publisher","DOI":"10.1002\/mus.880060404"},{"key":"e_1_2_1_26_2","volume-title":"Statistical Package for the Social Sciences","author":"Nie NH","year":"1975"},{"key":"e_1_2_1_27_2","doi-asserted-by":"publisher","DOI":"10.1113\/jphysiol.1966.sp007822"},{"key":"e_1_2_1_28_2","doi-asserted-by":"publisher","DOI":"10.1093\/bja\/51.3.171"},{"key":"e_1_2_1_29_2","doi-asserted-by":"publisher","DOI":"10.1093\/bja\/52.4.377"},{"key":"e_1_2_1_30_2","volume-title":"Scientific Information Retrieval","author":"Robinson BM","year":"1980"},{"key":"e_1_2_1_31_2","doi-asserted-by":"publisher","DOI":"10.1097\/00000542-197304000-00005"}],"container-title":["Muscle &amp; Nerve"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1002%2Fmus.880090211","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/mus.880090211","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,10,21]],"date-time":"2023-10-21T16:04:46Z","timestamp":1697904286000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/mus.880090211"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[1986,2]]},"references-count":30,"journal-issue":{"issue":"2","published-print":{"date-parts":[[1986,2]]}},"alternative-id":["10.1002\/mus.880090211"],"URL":"https:\/\/doi.org\/10.1002\/mus.880090211","archive":["Portico"],"relation":{},"ISSN":["0148-639X","1097-4598"],"issn-type":[{"value":"0148-639X","type":"print"},{"value":"1097-4598","type":"electronic"}],"subject":[],"published":{"date-parts":[[1986,2]]}}}