{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,18]],"date-time":"2026-01-18T01:54:40Z","timestamp":1768701280403,"version":"3.49.0"},"reference-count":16,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2004,10,13]],"date-time":"2004-10-13T00:00:00Z","timestamp":1097625600000},"content-version":"vor","delay-in-days":6495,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Muscle and Nerve"],"published-print":{"date-parts":[[1987,1]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Malignant hyperthermia (MH) is a hereditary myopathy, triggered when susceptible patients are exposed to a depolarizing muscle relaxant and\/or potent volatile anesthetics. We have studied the effects of dantrolene on the free [Ca<jats:sup>2+<\/jats:sup>]<jats:sub>i<\/jats:sub> of intercostal muscle biopsies obtained from two MH\u2010susceptible patients before and after administration of dantrolene orally (2.5 mg\/kg for 3 days) and intravenously (1.0 mg\/kg 2 hours before the biopsy). The free [Ca<jats:sup>2+<\/jats:sup>]<jats:sub>i<\/jats:sub> was measured by Ca<jats:sup>2+<\/jats:sup>\u2010selective microelectrodes. The mean resting free [Ca<jats:sup>2+<\/jats:sup>]<jats:sub>i<\/jats:sub> in the MH\u2010susceptible muscle before dantrolene treatment was 0.42 \u00b1 0.01 \u03bc<jats:italic>M<\/jats:italic> (mean \u00b1 SEM, <jats:italic>n<\/jats:italic> = 12). The administration of dantrolene reduced this value to 0.27 \u00b1 0.01 \u03bc<jats:italic>M<\/jats:italic> (<jats:italic>n<\/jats:italic> = 14). There was no detectable difference in the resting membrane potential after dantrolene. These results represent the first direct demonstration that dantrolene is able to reduc the resting free [Ca<jats:sup>2+<\/jats:sup>]<jats:sub>i<\/jats:sub> in skeletal muscle of MH\u2010susceptible patients.<\/jats:p>","DOI":"10.1002\/mus.880100114","type":"journal-article","created":{"date-parts":[[2005,1,1]],"date-time":"2005-01-01T07:17:59Z","timestamp":1104563879000},"page":"77-79","source":"Crossref","is-referenced-by-count":21,"title":["Dantrolene sodium is able to reduce the resting ionic [Ca<sup>2+<\/sup>]<sub>i<\/sub> In muscle from humans with malignant hyperthermia"],"prefix":"10.1002","volume":"10","author":[{"given":"Jos\u00e9 R.","family":"L\u00f3pez","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Pablo","family":"Medina","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Lorenzo","family":"Alamo","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2004,10,13]]},"reference":[{"key":"e_1_2_1_2_2","doi-asserted-by":"publisher","DOI":"10.1113\/jphysiol.1977.sp011731"},{"key":"e_1_2_1_3_2","doi-asserted-by":"publisher","DOI":"10.1007\/BF03006294"},{"key":"e_1_2_1_4_2","doi-asserted-by":"publisher","DOI":"10.1097\/00000542-198011000-00007"},{"key":"e_1_2_1_5_2","doi-asserted-by":"publisher","DOI":"10.1097\/00000542-197606000-00005"},{"key":"e_1_2_1_6_2","doi-asserted-by":"publisher","DOI":"10.1002\/mus.880020303"},{"key":"e_1_2_1_7_2","doi-asserted-by":"publisher","DOI":"10.1007\/BF03006711"},{"key":"e_1_2_1_8_2","doi-asserted-by":"publisher","DOI":"10.1016\/0005-2736(84)90187-1"},{"key":"e_1_2_1_9_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0006-3495(83)84316-1"},{"key":"e_1_2_1_10_2","doi-asserted-by":"publisher","DOI":"10.1002\/mus.880080502"},{"key":"e_1_2_1_11_2","first-page":"313a","article-title":"Dantrolene reverses the syndrome of malignant hyperthermia by reducing the level of intracellular [Ca2+]","volume":"47","author":"L\u00f3pez JR","year":"1985","journal-title":"Biophys J"},{"key":"e_1_2_1_12_2","first-page":"85","article-title":"[Ca2+]i in muscles of malignant hyperthermia susceptible pigs. Determined in vivo with Ca2+ selective microelectrodes","volume":"9","author":"L\u00f3pez JR","year":"1986","journal-title":"Muscle Nerve"},{"key":"e_1_2_1_13_2","first-page":"138","article-title":"The mechanism of action of dantrolene sodium","volume":"201","author":"Morgan KG","year":"1977","journal-title":"J Pharmacol Exp Ther"},{"key":"e_1_2_1_14_2","series-title":"Ann NY Acad Sci","first-page":"52","volume-title":"Calcium selective electrodes","author":"Simon W","year":"1978"},{"key":"e_1_2_1_15_2","first-page":"321","article-title":"Calcium movements in relation to muscle contraction","volume":"22","author":"Taylor SR","year":"1979","journal-title":"Proc West Pharmacol Soc"},{"key":"e_1_2_1_16_2","doi-asserted-by":"publisher","DOI":"10.1016\/0005-2736(80)90205-9"},{"key":"e_1_2_1_17_2","doi-asserted-by":"publisher","DOI":"10.1126\/science.959824"}],"container-title":["Muscle &amp; Nerve"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1002%2Fmus.880100114","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1002%2Fmus.880100114","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/mus.880100114","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,10,21]],"date-time":"2023-10-21T03:01:05Z","timestamp":1697857265000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/mus.880100114"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[1987,1]]},"references-count":16,"journal-issue":{"issue":"1","published-print":{"date-parts":[[1987,1]]}},"alternative-id":["10.1002\/mus.880100114"],"URL":"https:\/\/doi.org\/10.1002\/mus.880100114","archive":["Portico"],"relation":{},"ISSN":["0148-639X","1097-4598"],"issn-type":[{"value":"0148-639X","type":"print"},{"value":"1097-4598","type":"electronic"}],"subject":[],"published":{"date-parts":[[1987,1]]}}}