{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,11]],"date-time":"2026-04-11T17:40:36Z","timestamp":1775929236400,"version":"3.50.1"},"reference-count":14,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2004,10,13]],"date-time":"2004-10-13T00:00:00Z","timestamp":1097625600000},"content-version":"vor","delay-in-days":6436,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Muscle and Nerve"],"published-print":{"date-parts":[[1987,3]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Calcium uptake and (Ca<jats:sup>2+<\/jats:sup> + Mg<jats:sup>2+<\/jats:sup>)\u2010ATPase were measured in sarcoplasmic reticulum (SR) vesicles prepared from muscles of eight patients susceptible to malignant hyperthermia (MH) and eight control subjects. Intracellular resting free calcium level of some of the studied subjects was also determined. Both calcium uptake capacity and (Ca<jats:sup>2+<\/jats:sup> + Mg<jats:sup>2+<\/jats:sup>)\u2010ATPase activity were significantly lower in SR prepared from MH\u2010susceptible patients than from normal subjects. Besides, in these MH\u2010susceptible patients myoplasmic free Ca<jats:sup>2+<\/jats:sup> was increased. These results corroborate previous suggestions that abnormal function of the SR membrane was related to the MH syndrome.<\/jats:p>","DOI":"10.1002\/mus.880100307","type":"journal-article","created":{"date-parts":[[2005,1,1]],"date-time":"2005-01-01T07:18:29Z","timestamp":1104563909000},"page":"238-241","source":"Crossref","is-referenced-by-count":17,"title":["Deficient function of the sarcoplasmic reticulum in patients susceptible to malignant hyperthermia"],"prefix":"10.1002","volume":"10","author":[{"given":"Madalina","family":"Condrescu","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jos\u00e9 R.","family":"L\u00f3pez","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Pablo","family":"Medina","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Lorenzo","family":"Alamo","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2004,10,13]]},"reference":[{"key":"e_1_2_1_2_2","doi-asserted-by":"publisher","DOI":"10.1097\/00000542-198009001-00251"},{"key":"e_1_2_1_3_2","doi-asserted-by":"publisher","DOI":"10.1007\/BF03005702"},{"key":"e_1_2_1_4_2","first-page":"282a","article-title":"The high resting free calcium concentration in hyperthermic muscles might be associated to a diminished capacity of calcium uptake by the sarcoplasmic reticulum","volume":"47","author":"Condrescu M","year":"1985","journal-title":"Biophys J"},{"key":"e_1_2_1_5_2","doi-asserted-by":"crossref","first-page":"83","DOI":"10.2220\/biomedres.4.83","article-title":"Changes in the Ca\u2010induced Ca release mechanism in the sarcoplasmic reticulum of the muscle from a patient with malignant hyperthermia","volume":"4","author":"Endo M","year":"1983","journal-title":"Biomed Res"},{"key":"e_1_2_1_6_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0021-9258(18)84756-1"},{"key":"e_1_2_1_7_2","doi-asserted-by":"publisher","DOI":"10.1007\/BF03006711"},{"key":"e_1_2_1_8_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0006-3495(83)84316-1"},{"key":"e_1_2_1_9_2","doi-asserted-by":"publisher","DOI":"10.1002\/mus.880080502"},{"key":"e_1_2_1_10_2","first-page":"313a","article-title":"Free myoplasmic calcium concentration in skeletal fibers from malignant hyperthermia susceptible swine, measured in vivo with Ca2+\u2010selective microelectrodes","volume":"47","author":"L\u00f3pez JR","year":"1985","journal-title":"Biophys J"},{"key":"e_1_2_1_11_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0021-9258(19)52451-6"},{"key":"e_1_2_1_12_2","first-page":"648","article-title":"Sarcoplasmic reticulum. 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The uptake of Ca++ by sarcoplasmic reticulum fragments","volume":"239","author":"Martonosi A","year":"1964","journal-title":"J Biol Chem"},{"key":"e_1_2_1_13_2","doi-asserted-by":"publisher","DOI":"10.1016\/0005-2736(71)90036-8"},{"key":"e_1_2_1_14_2","doi-asserted-by":"publisher","DOI":"10.1016\/0014-5793(83)80739-X"},{"key":"e_1_2_1_15_2","doi-asserted-by":"publisher","DOI":"10.1016\/0005-2760(71)90069-5"}],"container-title":["Muscle &amp; Nerve"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1002%2Fmus.880100307","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1002%2Fmus.880100307","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/mus.880100307","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,10,20]],"date-time":"2023-10-20T23:35:40Z","timestamp":1697844940000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/mus.880100307"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[1987,3]]},"references-count":14,"journal-issue":{"issue":"3","published-print":{"date-parts":[[1987,3]]}},"alternative-id":["10.1002\/mus.880100307"],"URL":"https:\/\/doi.org\/10.1002\/mus.880100307","archive":["Portico"],"relation":{},"ISSN":["0148-639X","1097-4598"],"issn-type":[{"value":"0148-639X","type":"print"},{"value":"1097-4598","type":"electronic"}],"subject":[],"published":{"date-parts":[[1987,3]]}}}