{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,9,20]],"date-time":"2025-09-20T18:36:02Z","timestamp":1758393362798},"reference-count":20,"publisher":"Wiley","issue":"8","license":[{"start":{"date-parts":[[2004,10,13]],"date-time":"2004-10-13T00:00:00Z","timestamp":1097625600000},"content-version":"vor","delay-in-days":6222,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Muscle and Nerve"],"published-print":{"date-parts":[[1987,10]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>The content and distribution of acetylcholinesterase (AChE) activity in the skeletal muscle disorder malignant hyperthermia (MH) was examined. The AChE activity of sarcolemma membranes isolated from MH\u2010susceptible (MHS) swine was increased twofold when compared with normal sarcolemma. The total AChE activity of muscle extracts was also doubled in MHS tissue; however, the relative distribution between low\u2010salt extractable (globular forms) and high\u2010salt extractable (asymmetric forms) AChE activities were similar in MHS and normal muscle. Our results suggest that, for as yet unexplained reasons, both the sarcolemmal and total AChE activity of skeletal muscle is increased in porcine MH.<\/jats:p>","DOI":"10.1002\/mus.880100808","type":"journal-article","created":{"date-parts":[[2005,1,1]],"date-time":"2005-01-01T08:59:06Z","timestamp":1104569946000},"page":"723-727","source":"Crossref","is-referenced-by-count":6,"title":["Increased skeletal muscle acetylcholinesterase activity in porcine malignant hyperthermia"],"prefix":"10.1002","volume":"10","author":[{"given":"James R.","family":"Mickelson","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hemant S.","family":"Thatte","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Terrrence M.","family":"Beaudry","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Esther M.","family":"Gallant","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Charles F.","family":"Louis","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2004,10,13]]},"reference":[{"key":"e_1_2_1_2_2","first-page":"27","article-title":"Actions of sympathomimetic amines and their antagonists on skeletal muscle","volume":"21","author":"Bowman WC","year":"1969","journal-title":"Pharmacol Rev"},{"key":"e_1_2_1_3_2","doi-asserted-by":"publisher","DOI":"10.1016\/0301-0082(83)90015-1"},{"key":"e_1_2_1_4_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1471-4159.1982.tb07918.x"},{"key":"e_1_2_1_5_2","doi-asserted-by":"publisher","DOI":"10.1016\/0006-2952(61)90145-9"},{"key":"e_1_2_1_6_2","doi-asserted-by":"crossref","first-page":"83","DOI":"10.2220\/biomedres.4.83","article-title":"Changes in the Ca\u2010induced Ca release mechanism in the sarcoplasmic reticulum of the muscle from a patient with malignant hyperthermia","volume":"4","author":"Endo M","year":"1983","journal-title":"Biomed Res"},{"key":"e_1_2_1_7_2","first-page":"287","article-title":"Erythrocyte membrane enzyme abnormalities in two herediatry disorders of muscle","volume":"10","author":"Godin DV","year":"1979","journal-title":"J Med"},{"key":"e_1_2_1_8_2","doi-asserted-by":"crossref","first-page":"395","DOI":"10.1097\/00000542-198011000-00007","article-title":"Malignant hyperthermia","volume":"53","author":"Gronert GA","year":"1980","journal-title":"Aneshesiology"},{"key":"e_1_2_1_9_2","doi-asserted-by":"publisher","DOI":"10.1097\/00000542-197601000-00008"},{"key":"e_1_2_1_10_2","doi-asserted-by":"publisher","DOI":"10.1016\/0005-2736(84)90187-1"},{"key":"e_1_2_1_11_2","first-page":"309","volume-title":"Handbook of Physiology","author":"Lewis GP","year":"1975"},{"key":"e_1_2_1_12_2","doi-asserted-by":"publisher","DOI":"10.1093\/bja\/48.9.831"},{"key":"e_1_2_1_13_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0021-9258(19)52451-6"},{"key":"e_1_2_1_14_2","doi-asserted-by":"publisher","DOI":"10.1146\/annurev.ne.05.030182.000421"},{"key":"e_1_2_1_15_2","first-page":"195","article-title":"Acepromazine and droperidol inhibition of halothane\u2010indued malignant hyperthermia (porcine stress syndrome) in swine","volume":"42","author":"McGrath CJ","year":"1981","journal-title":"Am J Vet Res"},{"key":"e_1_2_1_16_2","doi-asserted-by":"publisher","DOI":"10.1016\/0003-9861(85)90485-0"},{"key":"e_1_2_1_17_2","first-page":"563a","article-title":"Calcium regulation by skeletal muscle sarcoplasmic reticulum and sarcolemma vesichles isolated from malignant hyperthermia susceptible pigs","volume":"49","author":"Mickelson JR","year":"1986","journal-title":"Biophys J"},{"key":"e_1_2_1_18_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0065-2628(08)60112-3"},{"key":"e_1_2_1_19_2","first-page":"500","article-title":"A radiometric microassay of acetylcholinesterase","volume":"156","author":"Potter LT","year":"1967","journal-title":"J Pharmacol Exp Ther"},{"key":"e_1_2_1_20_2","doi-asserted-by":"publisher","DOI":"10.1016\/0021-9975(72)90068-0"},{"key":"e_1_2_1_21_2","doi-asserted-by":"crossref","first-page":"13630","DOI":"10.1016\/S0021-9258(18)33494-X","article-title":"Cellular localization of the molecular forms of acetylcholinesterase in rat diaphragm","volume":"257","author":"Younkin SG","year":"1982","journal-title":"J Biol Chem"}],"container-title":["Muscle &amp; 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