{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,17]],"date-time":"2026-09-17T10:50:15Z","timestamp":1789642215589,"version":"4.0.0"},"reference-count":21,"publisher":"Wiley","issue":"6","license":[{"start":{"date-parts":[[2004,10,13]],"date-time":"2004-10-13T00:00:00Z","timestamp":1097625600000},"content-version":"vor","delay-in-days":5978,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Muscle and Nerve"],"published-print":{"date-parts":[[1988,6]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>In recent years, injection of pure glycerol into the trigeminal cistern has been used for the treatment of trigeminal neuralgia. The mechanism of action of this therapy remains unclear. Using both light and electron microscopy, we investigated the effects of microinjections of sterile, pure glycerol into the endoneurium of the sciatic nerve of the rat. We observed total destruction of both myelinated and unmyelinated fibers. In nearly all animals, signs of automutilation were observed in the paralyzed limb. Histological evidence of nerve degeneration appeared soon after injection, with intense proliferation of perineurial cells that eventually divided the endoneurium into numerous microcompartments.<\/jats:p>","DOI":"10.1002\/mus.880110604","type":"journal-article","created":{"date-parts":[[2005,1,1]],"date-time":"2005-01-01T05:15:36Z","timestamp":1104556536000},"page":"540-545","source":"Crossref","is-referenced-by-count":21,"title":["Effects of glycerol injection into rat sciatic nerve"],"prefix":"10.1002","volume":"11","author":[{"given":"J. M.","family":"Vallat","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"M. J.","family":"Leboutet","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"A.","family":"Loubet","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"J.","family":"Hugon","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"J. J.","family":"Moreau","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2004,10,13]]},"reference":[{"key":"e_1_2_1_2_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2990.1979.tb00644.x"},{"key":"e_1_2_1_3_2","doi-asserted-by":"publisher","DOI":"10.1016\/0014-4886(74)90073-9"},{"key":"e_1_2_1_4_2","doi-asserted-by":"publisher","DOI":"10.1016\/0014-4886(82)90250-3"},{"key":"e_1_2_1_5_2","doi-asserted-by":"publisher","DOI":"10.1001\/archneur.1984.04050220102026"},{"key":"e_1_2_1_6_2","doi-asserted-by":"publisher","DOI":"10.1097\/00006123-197903000-00009"},{"key":"e_1_2_1_7_2","doi-asserted-by":"publisher","DOI":"10.1227\/00006123-198112000-00005"},{"key":"e_1_2_1_8_2","doi-asserted-by":"publisher","DOI":"10.1097\/00006123-198202000-00026"},{"key":"e_1_2_1_9_2","doi-asserted-by":"publisher","DOI":"10.1007\/BF00696792"},{"key":"e_1_2_1_10_2","doi-asserted-by":"publisher","DOI":"10.1016\/0304-3959(79)90123-4"},{"key":"e_1_2_1_11_2","doi-asserted-by":"publisher","DOI":"10.1001\/jama.248.4.449"},{"key":"e_1_2_1_12_2","first-page":"299","article-title":"Letter to the Editor","volume":"10","author":"Lunsford LD","year":"1982","journal-title":"Neurosurgery"},{"key":"e_1_2_1_13_2","doi-asserted-by":"publisher","DOI":"10.1002\/mus.880030504"},{"key":"e_1_2_1_14_2","doi-asserted-by":"publisher","DOI":"10.1097\/00006123-198312000-00012"},{"key":"e_1_2_1_15_2","doi-asserted-by":"publisher","DOI":"10.1038\/272639a0"},{"key":"e_1_2_1_16_2","first-page":"17","article-title":"Syndrome de Guillain\u2010Barr\u00e9: effects \u00e9lectrophysiologiques et morphologiques du s\u00e9rum humain introduit dans l'espace endoneural du nerf sciatique du rat. R\u00e9sultats pr\u00e9liminaires","volume":"138","author":"Sumner A","year":"1982","journal-title":"Rev Neurol (Paris)"},{"key":"e_1_2_1_17_2","doi-asserted-by":"publisher","DOI":"10.1097\/00006123-198112000-00006"},{"key":"e_1_2_1_18_2","doi-asserted-by":"publisher","DOI":"10.1097\/00000637-197803000-00011"},{"key":"e_1_2_1_19_2","doi-asserted-by":"publisher","DOI":"10.1007\/BF00685008"},{"key":"e_1_2_1_20_2","first-page":"659","article-title":"Effects morphologiques de microinjections de s\u00e9rum de rat Lewis dans le nerf de rat Lewis","volume":"140","author":"Vallat JM","year":"1984","journal-title":"Rev Neurol (Paris)"},{"key":"e_1_2_1_21_2","first-page":"681","article-title":"The spanish toxic\u2010oil syndrome","volume":"7","author":"Vallat JM","year":"1984","journal-title":"Muscle Nerve"},{"key":"e_1_2_1_22_2","unstructured":"VallatJM LeboutetMJ MoreauJJ HugonJ FressinaudC DechambenoitG: Proliferation of perineural cells during experimental regeneration of peripheral nerve. Xth International Congress of Neuropathology Stockholm September 7\u20139 1986."}],"container-title":["Muscle &amp; Nerve"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1002%2Fmus.880110604","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/mus.880110604","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,10,22]],"date-time":"2023-10-22T17:32:15Z","timestamp":1697995935000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/mus.880110604"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[1988,6]]},"references-count":21,"journal-issue":{"issue":"6","published-print":{"date-parts":[[1988,6]]}},"alternative-id":["10.1002\/mus.880110604"],"URL":"https:\/\/doi.org\/10.1002\/mus.880110604","archive":["Portico"],"relation":{},"ISSN":["0148-639X","1097-4598"],"issn-type":[{"value":"0148-639X","type":"print"},{"value":"1097-4598","type":"electronic"}],"subject":[],"published":{"date-parts":[[1988,6]]}}}