{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,2]],"date-time":"2026-07-02T13:05:08Z","timestamp":1782997508320,"version":"3.54.5"},"reference-count":36,"publisher":"Wiley","issue":"11","license":[{"start":{"date-parts":[[2004,10,13]],"date-time":"2004-10-13T00:00:00Z","timestamp":1097625600000},"content-version":"vor","delay-in-days":5825,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Muscle and Nerve"],"published-print":{"date-parts":[[1988,11]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Antibodies in individual patients with the Lambert\u2013Eaton myasthenic syndrome (LES) differ in their reactivity with mouse motor nerve terminals. Of 26 LES patients' sera injected a single time into mice, 3 caused a highly significant reduction in stimulus\u2010dependent quantal release (<jats:italic>m<\/jats:italic>) of acetylcholine (ACh) (to 6, 33, and 42 quanta per impulse at 1 Hz, respectively; mean for 10 control sera, 100 quanta at 1 Hz). The most potent serum (LES\u2010A) was fully effective in mice deficient in complement component C5 and in mice depleted of complement components C3\u2192C9 by cobra venom factor. A single i.v. injection of serum reduced <jats:italic>m<\/jats:italic> in direct proportion to log dose. Responses to K<jats:sup>+<\/jats:sup> depolarization and increasing concentrations of Ca<jats:sup>2+<\/jats:sup> were like those observed in human LES.<\/jats:p><jats:p>With LES\u2010A serum, or its IgG, <jats:italic>m<\/jats:italic> was reduced near maximally in 1 day and plateaued in 3\u20134 days. Recovery began after day 8; <jats:italic>m<\/jats:italic> was in the normal range by day 20\u201330. Electromyographic (EMG) abnormalities were not seen until <jats:italic>m<\/jats:italic> fell below 40 quanta per impulse at 1 Hz. Below 10 quanta, clinical signs of weakness appeared, and the EMG abnormalities were those classically associated with LES: a marked reduction of compound muscle action potential to a single nerve stimulus in rested muscle, a further decrement during stimulation at slow rates, but marked facilitation during rapid repetitive stimulation.<\/jats:p>","DOI":"10.1002\/mus.880111105","type":"journal-article","created":{"date-parts":[[2005,1,1]],"date-time":"2005-01-01T05:09:40Z","timestamp":1104556180000},"page":"1133-1145","source":"Crossref","is-referenced-by-count":51,"title":["Selected IgG rapidly induces Lambert\u2013Eaton myasthenic syndrome in mice: Complement independence and EMG abnormalities"],"prefix":"10.1002","volume":"11","author":[{"given":"Edward H.","family":"Lambert","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Vanda A.","family":"Lennon","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2004,10,13]]},"reference":[{"key":"e_1_2_1_2_2","doi-asserted-by":"publisher","DOI":"10.1113\/jphysiol.1980.sp013145"},{"key":"e_1_2_1_3_2","doi-asserted-by":"publisher","DOI":"10.1002\/ana.410110604"},{"key":"e_1_2_1_4_2","first-page":"1380","article-title":"Autoantibodies antagonize voltage\u2010sensitive Ca2+ channels in small cell carcinomas (SCC) from patients with and without Lambert\u2010Eaton myasthenic syndrome (LES)","volume":"46","author":"De Aizpurua HJ","year":"1987","journal-title":"Fed Proc"},{"key":"e_1_2_1_5_2","doi-asserted-by":"publisher","DOI":"10.1113\/jphysiol.1954.sp005129"},{"key":"e_1_2_1_6_2","first-page":"689","article-title":"Detailed analysis of neuromuscular transmission in a patient with the myasthenic syndrome sometimes associated with bronchogenic carcinoma","volume":"43","author":"Elmqvist D","year":"1968","journal-title":"Mayo Clin Proc"},{"key":"e_1_2_1_7_2","doi-asserted-by":"publisher","DOI":"10.1113\/jphysiol.1965.sp007639"},{"key":"e_1_2_1_8_2","first-page":"267","article-title":"Immune complexes (IgG and C3) at the motor end\u2010plate in myasthenia gravis. 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