{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,4]],"date-time":"2026-02-04T14:50:21Z","timestamp":1770216621181,"version":"3.49.0"},"reference-count":24,"publisher":"Wiley","issue":"12","license":[{"start":{"date-parts":[[2004,10,13]],"date-time":"2004-10-13T00:00:00Z","timestamp":1097625600000},"content-version":"vor","delay-in-days":5795,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Muscle and Nerve"],"published-print":{"date-parts":[[1988,12]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>In vivo <jats:sup>31<\/jats:sup>phosphorus nuclear magnetic resonance spectroscopy (P\u2010NMR) on the anterior tibialis muscle was used to investigate the metabolic myopathy of inherited muscle\u2010type phosphofructokinase (PFK) deficiency in four (homozygous) dogs who had mild exercise intolerance, rare muscle cramps, increased serum creatine kinase activity, but no myoglobinuria. During isometric muscle work induced by indirect electrical stimulation, and subsequent recovery, changes in the ratio of phosphocreatine (PCr) and inorganic phosphates (P<jats:sub>i<\/jats:sub>) were comparable in muscle of PFK\u2010deficient and normal dogs and indicated a large capacity for arobic oxidative phosphorylation in canine muscle. The progressive accumulation of sugar phosphates (PME) during graded exercise clearly demonstrated the glycolytic block in PFK\u2010deficient dogs. During a muscle contracture, induced by acute muscle stimulation, PFK\u2010deficient muscle became completely depleted of PCr and ATP, accumulated large amounts of PME, and recovered very slowly. We conclude that PFK\u2010deficient dogs have a metabolic myopathy that demonstrated some but not all the features recognized in the human disorder.<\/jats:p>","DOI":"10.1002\/mus.880111210","type":"journal-article","created":{"date-parts":[[2005,1,1]],"date-time":"2005-01-01T05:09:49Z","timestamp":1104556189000},"page":"1260-1265","source":"Crossref","is-referenced-by-count":37,"title":["Metabolic myopathy in canine muscle\u2010type phosphofructokinase deficiency"],"prefix":"10.1002","volume":"11","author":[{"given":"Urs","family":"Giger","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Zohar","family":"Argov","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mitch","family":"Schnall","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"William J.","family":"Bank","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Britton","family":"Chance","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2004,10,13]]},"reference":[{"key":"e_1_2_1_2_2","doi-asserted-by":"publisher","DOI":"10.1212\/WNL.37.11.1720"},{"key":"e_1_2_1_3_2","doi-asserted-by":"publisher","DOI":"10.1002\/ana.410220112"},{"key":"e_1_2_1_4_2","doi-asserted-by":"crossref","first-page":"1428","DOI":"10.1152\/jappl.1987.63.4.1428","article-title":"Continuous graded steady state muscle work in rats studied in vivo by phosphorus NMR","volume":"63","author":"Argov Z","year":"1987","journal-title":"J Appl Physiol"},{"key":"e_1_2_1_5_2","first-page":"93","article-title":"Rat muscle glycolysis blocked by iodoacetate is similar to human PFK deficiency when measured by 31P NMR","volume":"36","author":"Argov Z","year":"1986","journal-title":"Neurology (NY)"},{"key":"e_1_2_1_6_2","doi-asserted-by":"publisher","DOI":"10.1002\/ana.410180205"},{"key":"e_1_2_1_7_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1749-6632.1987.tb32934.x"},{"key":"e_1_2_1_8_2","doi-asserted-by":"crossref","first-page":"25","DOI":"10.1152\/jappl.1964.19.1.25","article-title":"Aerobic and anaerobic metbolism in exercising dogs","volume":"19","author":"Cerretelli P","year":"1964","journal-title":"J Appl Physiol"},{"key":"e_1_2_1_9_2","first-page":"103","article-title":"Phosphorus nuclear magnetic resonance spectroscopy in vivo","volume":"72","author":"Chance B","year":"1985","journal-title":"Circulation (Suppl)"},{"key":"e_1_2_1_10_2","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.79.24.7714"},{"key":"e_1_2_1_11_2","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.78.11.6714"},{"key":"e_1_2_1_12_2","doi-asserted-by":"publisher","DOI":"10.1113\/jphysiol.1932.sp002949"},{"key":"e_1_2_1_13_2","unstructured":"DubrocD JehensonP FardeauM SyrotaA Tran DinhS: Phosphofructokinase and phosphoglyceratekinase deficient human skeletal muscle studied by31P\u2010NMR spectroscopy in: Proceedings of the 4th Meeting of the Society of Resonance Medicine London 1985 pp463\u2013464."},{"key":"e_1_2_1_14_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(82)92635-6"},{"key":"e_1_2_1_15_2","doi-asserted-by":"publisher","DOI":"10.1182\/blood.V65.2.345.345"},{"key":"e_1_2_1_16_2","doi-asserted-by":"crossref","first-page":"37","DOI":"10.1159\/000469137","article-title":"Biochemical studies of canine muscle phosphofructokinase deficiency","volume":"40","author":"Giger U","year":"1988","journal-title":"Enzyme"},{"key":"e_1_2_1_17_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2052.1986.tb03184.x"},{"key":"e_1_2_1_18_2","doi-asserted-by":"publisher","DOI":"10.1002\/mus.880090205"},{"key":"e_1_2_1_19_2","first-page":"1907","volume-title":"Myology","author":"Layzer RB","year":"1986"},{"key":"e_1_2_1_20_2","doi-asserted-by":"crossref","first-page":"C14","DOI":"10.1152\/ajpcell.1977.233.1.C14","article-title":"Physiological characteristics of skeletal muscles of dogs and cats","volume":"133","author":"Maxwell LC","year":"1977","journal-title":"Am J Physiol"},{"key":"e_1_2_1_21_2","doi-asserted-by":"publisher","DOI":"10.1056\/NEJM198105283042206"},{"key":"e_1_2_1_22_2","first-page":"1603","volume-title":"Myology","author":"Rowland LP","year":"1986"},{"key":"e_1_2_1_23_2","doi-asserted-by":"publisher","DOI":"10.1007\/BF00492533"},{"key":"e_1_2_1_24_2","first-page":"71","volume-title":"Neuromuscular Diseases","author":"Tarui S","year":"1984"},{"key":"e_1_2_1_25_2","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.82.23.8109"}],"container-title":["Muscle &amp; 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