{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,5,20]],"date-time":"2025-05-20T23:26:59Z","timestamp":1747783619573},"reference-count":21,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2004,10,13]],"date-time":"2004-10-13T00:00:00Z","timestamp":1097625600000},"content-version":"vor","delay-in-days":5733,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Muscle and Nerve"],"published-print":{"date-parts":[[1989,2]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>In both control pigs and pigs susceptible to malignant hyperpyrexia (MH), the size of the calcium current (<jats:italic>I<\/jats:italic><jats:sub>Ca<\/jats:sub>) and the amount of asymmetric charge movement varied considerably between different gracilis muscle fibers but appeared to vary in parallel. The mean amount of both <jats:italic>I<\/jats:italic><jats:sub>Ca<\/jats:sub> and charge movement were slightly but significantly smaller in MH\u2010susceptible (MHS) muscle compared with normal muscle. Halothane (1% v\/v) reduced both parameters by almost 50%. One interpretation of the data is that the signal, which couples depolarization to calcium release from the sarcoplasmic reticulum, is abnormal in MHS muscle.<\/jats:p>","DOI":"10.1002\/mus.880120208","type":"journal-article","created":{"date-parts":[[2005,1,1]],"date-time":"2005-01-01T09:21:33Z","timestamp":1104571293000},"page":"135-140","source":"Crossref","is-referenced-by-count":9,"title":["Calcium currents and asymmetric charge movement in malignant hyperpyrexia"],"prefix":"10.1002","volume":"12","author":[{"given":"Graham D.","family":"Lamb","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kenneth C.","family":"Hopkinson","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Michael A.","family":"Denborough","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2004,10,13]]},"reference":[{"key":"e_1_2_1_2_2","doi-asserted-by":"publisher","DOI":"10.1113\/jphysiol.1981.sp013622"},{"key":"e_1_2_1_3_2","doi-asserted-by":"publisher","DOI":"10.1007\/BF01753649"},{"key":"e_1_2_1_4_2","doi-asserted-by":"publisher","DOI":"10.1113\/jphysiol.1976.sp011232"},{"key":"e_1_2_1_5_2","doi-asserted-by":"publisher","DOI":"10.1085\/jgp.82.4.449"},{"key":"e_1_2_1_6_2","first-page":"551a","article-title":"Skeletal muscle excitation\u2010contraction coupling: transverse tubule control of sarcoplasmic reticulum Ca2+\u2010induced Ca2+ release","volume":"51","author":"Donaldson SK","year":"1987","journal-title":"Biophys J"},{"key":"e_1_2_1_7_2","doi-asserted-by":"publisher","DOI":"10.1113\/jphysiol.1983.sp014802"},{"key":"e_1_2_1_8_2","doi-asserted-by":"publisher","DOI":"10.1016\/0079-6107(84)90009-9"},{"key":"e_1_2_1_9_2","first-page":"551a","article-title":"Skeletal muscle excitation\u2010contraction coupling: plasmalemmal alteration in malignant hyperthermia","volume":"51","author":"Gallant EM","year":"1987","journal-title":"Biophys J"},{"key":"e_1_2_1_10_2","doi-asserted-by":"publisher","DOI":"10.1002\/mus.880020610"},{"key":"e_1_2_1_11_2","doi-asserted-by":"publisher","DOI":"10.1097\/00000542-198011000-00007"},{"key":"e_1_2_1_12_2","first-page":"575","volume-title":"Skeletal Muscle Pathology","author":"Harriman DGF","year":"1982"},{"key":"e_1_2_1_13_2","doi-asserted-by":"publisher","DOI":"10.1113\/jphysiol.1981.sp014004"},{"key":"e_1_2_1_14_2","doi-asserted-by":"publisher","DOI":"10.1113\/jphysiol.1981.sp013725"},{"key":"e_1_2_1_15_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0006-3495(86)83573-1"},{"key":"e_1_2_1_16_2","doi-asserted-by":"publisher","DOI":"10.1113\/jphysiol.1986.sp016142"},{"key":"e_1_2_1_17_2","doi-asserted-by":"publisher","DOI":"10.1113\/jphysiol.1987.sp016843"},{"key":"e_1_2_1_18_2","doi-asserted-by":"publisher","DOI":"10.1002\/mus.880080502"},{"key":"e_1_2_1_19_2","doi-asserted-by":"publisher","DOI":"10.1136\/bmj.2.5913.241"},{"key":"e_1_2_1_20_2","doi-asserted-by":"publisher","DOI":"10.1093\/bja\/51.3.171"},{"key":"e_1_2_1_21_2","doi-asserted-by":"publisher","DOI":"10.1038\/325717a0"},{"key":"e_1_2_1_22_2","doi-asserted-by":"publisher","DOI":"10.1038\/328313a0"}],"container-title":["Muscle &amp; Nerve"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1002%2Fmus.880120208","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/mus.880120208","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,10,22]],"date-time":"2023-10-22T03:28:56Z","timestamp":1697945336000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/mus.880120208"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[1989,2]]},"references-count":21,"journal-issue":{"issue":"2","published-print":{"date-parts":[[1989,2]]}},"alternative-id":["10.1002\/mus.880120208"],"URL":"https:\/\/doi.org\/10.1002\/mus.880120208","archive":["Portico"],"relation":{},"ISSN":["0148-639X","1097-4598"],"issn-type":[{"value":"0148-639X","type":"print"},{"value":"1097-4598","type":"electronic"}],"subject":[],"published":{"date-parts":[[1989,2]]}}}