{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,23]],"date-time":"2025-10-23T05:16:53Z","timestamp":1761196613135},"reference-count":20,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2004,10,13]],"date-time":"2004-10-13T00:00:00Z","timestamp":1097625600000},"content-version":"vor","delay-in-days":5705,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Muscle and Nerve"],"published-print":{"date-parts":[[1989,3]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>We studied the electrical properties of intact muscle fibers from normal and malignant hyperthemia\u2010susceptible (MHS) pigs. Resting membrane potentials, action potentials, and current\u2010voltage relationships were measured with without the presence of halothane. There were no changes in the resting potentials or the specific membrane conductances at any concentration of halothane in either the normal or MHS fibers. The current\u2010voltage relationships of normal and MHS fibers did not differ. Contractures were observed in MHS muscle when the concentration of halothane was \u22650.8%. These halothane\u2010induced contractures were not associated with depolarization of the surface membrane. Contractures were not observed in normal muscle even at concentrations of 6.0% halothane. In contrast, halothane altered the shape of the action potentials of both MHS and normal fibers. However these changes were significantly greater in MHS fibers, occurred at much lower concentrations, and were partially prevented by preincubation in 10 \u03bc<jats:italic>M<\/jats:italic> dantrolene.<\/jats:p>","DOI":"10.1002\/mus.880120303","type":"journal-article","created":{"date-parts":[[2005,1,1]],"date-time":"2005-01-01T09:21:51Z","timestamp":1104571311000},"page":"178-183","source":"Crossref","is-referenced-by-count":14,"title":["Malignant hyperthermia: Effects of halothane on the surface membrane"],"prefix":"10.1002","volume":"12","author":[{"given":"Paul A.","family":"Iaizzo","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Frank","family":"Lehmamn\u2010Horn","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Stuart R.","family":"Taylor","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Esther M.","family":"Gallant","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2004,10,13]]},"reference":[{"key":"e_1_2_1_2_2","doi-asserted-by":"publisher","DOI":"10.1177\/00359157730661P133"},{"key":"e_1_2_1_3_2","first-page":"213","article-title":"Mechanical activation and electrophysiological properties of intercostal muscle fibers from malignant\u2010hyperthermia\u2010susceptible (MHS) pigs","volume":"3","author":"Bryant SH","year":"1977","journal-title":"Neurosci Abstr"},{"key":"e_1_2_1_4_2","doi-asserted-by":"crossref","first-page":"83","DOI":"10.2220\/biomedres.4.83","article-title":"Changes in the Ca\u2010induced Ca release mechanism in the sarcoplasmic reticulum of the muscle from a patient with malignant hyperthermia","volume":"4","author":"Endo M","year":"1983","journal-title":"Biomed Res"},{"key":"e_1_2_1_5_2","first-page":"785","article-title":"Porcine malignant hyperthermia: no role for plasmalemmal depolarization","volume":"11","author":"Gallant EM","year":"1988","journal-title":"Muscle Nerve"},{"key":"e_1_2_1_6_2","doi-asserted-by":"publisher","DOI":"10.1002\/mus.880090211"},{"key":"e_1_2_1_7_2","doi-asserted-by":"publisher","DOI":"10.1002\/mus.880020610"},{"key":"e_1_2_1_8_2","first-page":"91","article-title":"Mechanical properties of normal and malignant hyperthermia susceptible porcine muscle: effects of halothane and other drugs","volume":"213","author":"Gallant EM","year":"1980","journal-title":"J Pharmacol Exp Ther"},{"key":"e_1_2_1_9_2","doi-asserted-by":"publisher","DOI":"10.1016\/0304-3940(82)90149-5"},{"key":"e_1_2_1_10_2","first-page":"1763","volume-title":"Myology","author":"Gronert GA","year":"1986"},{"key":"e_1_2_1_11_2","doi-asserted-by":"publisher","DOI":"10.1016\/0014-2999(79)90010-4"},{"key":"e_1_2_1_12_2","doi-asserted-by":"publisher","DOI":"10.1007\/BF00580861"},{"key":"e_1_2_1_13_2","doi-asserted-by":"publisher","DOI":"10.1007\/BF00583934"},{"key":"e_1_2_1_14_2","doi-asserted-by":"publisher","DOI":"10.1002\/mus.880040508"},{"key":"e_1_2_1_15_2","first-page":"313a","article-title":"Dantrolene reverses the syndrome of malignant hyperthermia by reducing the level of intracellular Ca2cc+","volume":"47","author":"Lopez JR","year":"1985","journal-title":"Biophys J"},{"key":"e_1_2_1_16_2","first-page":"1734","article-title":"Halothane testing for malignant hyperthermia in swine: dose\u2010response effects","volume":"45","author":"McGrath CJ","year":"1984","journal-title":"Am J Vet Res"},{"key":"e_1_2_1_17_2","doi-asserted-by":"publisher","DOI":"10.1016\/0014-5793(84)80845-5"},{"key":"e_1_2_1_18_2","doi-asserted-by":"publisher","DOI":"10.1016\/0014-5793(83)80739-X"},{"key":"e_1_2_1_19_2","first-page":"1116","article-title":"Role of the action potential in excitation\u2010contraction coupling","volume":"24","author":"Sandow A","year":"1965","journal-title":"Fed Proc"},{"key":"e_1_2_1_20_2","first-page":"13","volume-title":"Effects of Anesthesia","author":"Urban BW","year":"1985"},{"key":"e_1_2_1_21_2","doi-asserted-by":"publisher","DOI":"10.1097\/00000542-197304000-00005"}],"container-title":["Muscle &amp; 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