{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,9,26]],"date-time":"2025-09-26T22:20:16Z","timestamp":1758925216247},"reference-count":34,"publisher":"Wiley","issue":"5","license":[{"start":{"date-parts":[[2004,10,13]],"date-time":"2004-10-13T00:00:00Z","timestamp":1097625600000},"content-version":"vor","delay-in-days":5644,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Muscle and Nerve"],"published-print":{"date-parts":[[1989,5]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p><jats:sup>31<\/jats:sup>Phosphorus\u2010NMR spectroscopy may have the potential to help in the noninvasive diagnosis of malignant hyperpyrexia (MH). Changes in the phosphate\u2010metabolite profile of MH\u2010susceptible (MHS) skeletal muscle occur more readily under conditions of anoxia than in control muscle. Induction of anoxia caused a rapid fall in intracellular phosphocreatine, an elevation of inorganic phosphate, and finally a diminution of ATP in MHS muscle. The onset of metabolic change was slower in control tissue. Increased oxygen consumption may occur in anoxic MHS muscle, which leads to accelerated glycolysis and a rapid fall in the intracellular high\u2010energy phosphates. In MHS muscle an abnormality may exist in carbohydrate metabolism linked with poor resynthesis of the high\u2010energy phosphates, which may be precipitated under anaerobic conditions. Accelerated muscle metabolism is also observed in the presence of 2 m<jats:italic>M<\/jats:italic> caffeine and 3% halothane in MHS muscle. Changes in the concentrations of metabolites could be mapped noninvasively under anoxic conditions using topical <jats:sup>31<\/jats:sup>P\u2010NMR.<\/jats:p>","DOI":"10.1002\/mus.880120509","type":"journal-article","created":{"date-parts":[[2005,1,1]],"date-time":"2005-01-01T05:14:16Z","timestamp":1104556456000},"page":"390-396","source":"Crossref","is-referenced-by-count":5,"title":["<sup>31<\/sup>P\u2010NMR spectroscopy: The metabolic profile of malignant hyperpyrexic porcine skeletal muscle"],"prefix":"10.1002","volume":"12","author":[{"given":"Paul S.","family":"Foster","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kenneth","family":"Hopkinson","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Michael","family":"Denborough","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2004,10,13]]},"reference":[{"key":"e_1_2_1_2_2","doi-asserted-by":"publisher","DOI":"10.1093\/bja\/55.6.531"},{"key":"e_1_2_1_3_2","doi-asserted-by":"publisher","DOI":"10.1002\/jss.400030205"},{"key":"e_1_2_1_4_2","doi-asserted-by":"publisher","DOI":"10.1038\/225653a0"},{"key":"e_1_2_1_5_2","first-page":"89","volume-title":"Advances in Food Research","author":"Briskey EJ","year":"1964"},{"key":"e_1_2_1_6_2","doi-asserted-by":"publisher","DOI":"10.1007\/BF03005702"},{"key":"e_1_2_1_7_2","doi-asserted-by":"publisher","DOI":"10.1126\/science.188132"},{"key":"e_1_2_1_8_2","doi-asserted-by":"publisher","DOI":"10.1113\/jphysiol.1977.sp011835"},{"key":"e_1_2_1_9_2","doi-asserted-by":"publisher","DOI":"10.1038\/274861a0"},{"key":"e_1_2_1_10_2","doi-asserted-by":"publisher","DOI":"10.1016\/0163-7258(80)90023-6"},{"key":"e_1_2_1_11_2","doi-asserted-by":"publisher","DOI":"10.1136\/bmj.3.5982.511"},{"key":"e_1_2_1_12_2","doi-asserted-by":"publisher","DOI":"10.1002\/jps.2600620619"},{"key":"e_1_2_1_13_2","doi-asserted-by":"crossref","first-page":"84","DOI":"10.2220\/biomedres.4.83","article-title":"Changes in the Ca\u2010induced Ca release mechanism in the sarcoplasmic reticulum of the muscle from a patient with malignant hyperthermia","volume":"4","author":"Endo M","year":"1983","journal-title":"Biomed Res"},{"key":"e_1_2_1_14_2","doi-asserted-by":"publisher","DOI":"10.1016\/0006-291X(77)91653-9"},{"key":"e_1_2_1_15_2","doi-asserted-by":"publisher","DOI":"10.1097\/00000542-198304000-00008"},{"key":"e_1_2_1_16_2","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.77.1.299"},{"key":"e_1_2_1_17_2","doi-asserted-by":"publisher","DOI":"10.1093\/bja\/41.10.844"},{"key":"e_1_2_1_18_2","doi-asserted-by":"publisher","DOI":"10.1016\/0022-2364(78)90156-7"},{"key":"e_1_2_1_19_2","doi-asserted-by":"publisher","DOI":"10.1038\/252285a0"},{"key":"e_1_2_1_20_2","doi-asserted-by":"publisher","DOI":"10.1093\/bja\/47.4.475"},{"key":"e_1_2_1_21_2","doi-asserted-by":"publisher","DOI":"10.1093\/bja\/47.10.1075"},{"key":"e_1_2_1_22_2","doi-asserted-by":"publisher","DOI":"10.5694\/j.1326-5377.1972.tb47015.x"},{"key":"e_1_2_1_23_2","series-title":"Fourth International Symposium on Malignant Hyperpyrexia","first-page":"12","volume-title":"31P\u2010NMR spectroscopy in subjects susceptible to malignant (MH) or exercise (EH) hyperthermia","author":"Kozak\u2010Reiss G","year":"1986"},{"key":"e_1_2_1_24_2","doi-asserted-by":"publisher","DOI":"10.1152\/physrev.1984.64.4.1240"},{"key":"e_1_2_1_25_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1440-1681.1974.tb00542.x"},{"key":"e_1_2_1_26_2","doi-asserted-by":"publisher","DOI":"10.1097\/00000542-197201000-00009"},{"key":"e_1_2_1_27_2","doi-asserted-by":"publisher","DOI":"10.1093\/bja\/51.3.171"},{"key":"e_1_2_1_28_2","first-page":"A230","article-title":"Intermediate uncoupling of high energy oxidative phosphorylation in muscle of malignant hyperthermic swine determined non\u2010invasively by whole body 31P\u2010NMR. 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