{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,19]],"date-time":"2026-08-19T17:33:09Z","timestamp":1787160789460,"version":"build-2736575974"},"reference-count":52,"publisher":"Wiley","issue":"8","license":[{"start":{"date-parts":[[2004,10,13]],"date-time":"2004-10-13T00:00:00Z","timestamp":1097625600000},"content-version":"vor","delay-in-days":5552,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Muscle and Nerve"],"published-print":{"date-parts":[[1989,8]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>Clinical testing for neuromuscular dysfunction is supported by an extensive amount of excellent basic information about normal and abnormal subcellular physiology and ultrastructure. This information provides an essential frame of reference for describing the rationale of single\u2010fiber electromyography (SFEMG). SFEMG in turn helps to explain the more conventional clinical testing of neuromuscular function by repetitive nerve stimulation (RNS). Electrical findings in myasthenia gravis, Lambert\u2013Eaton myasthenic syndrome, and botulinum intoxication are discussed from the subcellular level via the cellular level (SFEMG) to the integrated responses of whole muscle (RNS) as a rational means of understanding the technique of clinical repetitive nerve stimulation.<\/jats:p>","DOI":"10.1002\/mus.880120802","type":"journal-article","created":{"date-parts":[[2005,1,1]],"date-time":"2005-01-01T04:27:03Z","timestamp":1104553623000},"page":"613-626","source":"Crossref","is-referenced-by-count":125,"title":["AAEE minimonograph #33: Electrodiagnostic approach to defects of neuromuscular transmission"],"prefix":"10.1002","volume":"12","author":[{"given":"John C.","family":"Keesey","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2004,10,13]]},"reference":[{"key":"e_1_2_1_2_2","doi-asserted-by":"publisher","DOI":"10.1212\/WNL.27.9.812"},{"key":"e_1_2_1_3_2","doi-asserted-by":"publisher","DOI":"10.1212\/WNL.31.2.202"},{"key":"e_1_2_1_4_2","first-page":"S28","article-title":"Electrophysiologic methods as an aid in diagnosis of botulism, a review","volume":"5","author":"Cherington M","year":"1982","journal-title":"Muscle Nerve"},{"key":"e_1_2_1_5_2","doi-asserted-by":"publisher","DOI":"10.1001\/archneur.1977.00500160050009"},{"key":"e_1_2_1_6_2","doi-asserted-by":"publisher","DOI":"10.1002\/mus.880060609"},{"key":"e_1_2_1_7_2","doi-asserted-by":"publisher","DOI":"10.1002\/mus.880080707"},{"key":"e_1_2_1_8_2","doi-asserted-by":"publisher","DOI":"10.1113\/jphysiol.1976.sp011510"},{"key":"e_1_2_1_9_2","doi-asserted-by":"publisher","DOI":"10.1113\/jphysiol.1980.sp013145"},{"key":"e_1_2_1_10_2","doi-asserted-by":"publisher","DOI":"10.1001\/archneur.1973.00490300087012"},{"key":"e_1_2_1_11_2","first-page":"42P","article-title":"Lack of interaction between botulinum neurotoxin and Lambert\u2010Eaton myasthenic syndrome IgG at mouse motor nerve terminals","volume":"376","author":"Dolly JO","year":"1986","journal-title":"J Physiol (Lond)"},{"key":"e_1_2_1_12_2","first-page":"63","volume-title":"The Understanding of the Brain","author":"Eccles JC","year":"1972"},{"key":"e_1_2_1_13_2","doi-asserted-by":"publisher","DOI":"10.1113\/jphysiol.1965.sp007639"},{"key":"e_1_2_1_14_2","doi-asserted-by":"publisher","DOI":"10.1136\/jnnp.43.7.577"},{"key":"e_1_2_1_15_2","doi-asserted-by":"publisher","DOI":"10.1002\/ana.410160502"},{"key":"e_1_2_1_16_2","doi-asserted-by":"publisher","DOI":"10.1002\/ana.410010403"},{"key":"e_1_2_1_17_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1749-6632.1981.tb33762.x"},{"key":"e_1_2_1_18_2","doi-asserted-by":"publisher","DOI":"10.1002\/ana.410110603"},{"key":"e_1_2_1_19_2","doi-asserted-by":"publisher","DOI":"10.1002\/mus.880050911"},{"key":"e_1_2_1_20_2","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.80.24.7636"},{"key":"e_1_2_1_21_2","doi-asserted-by":"publisher","DOI":"10.1002\/mus.880050905"},{"key":"e_1_2_1_22_2","doi-asserted-by":"publisher","DOI":"10.1002\/mus.880100306"},{"key":"e_1_2_1_23_2","doi-asserted-by":"publisher","DOI":"10.1212\/WNL.23.9.977"},{"key":"e_1_2_1_24_2","first-page":"797","article-title":"Myasthenia gravis\u2014Current concepts","volume":"142","author":"Herrmann C","year":"1985","journal-title":"West J Med"},{"key":"e_1_2_1_25_2","doi-asserted-by":"publisher","DOI":"10.1002\/mus.880050307"},{"key":"e_1_2_1_26_2","doi-asserted-by":"publisher","DOI":"10.1002\/mus.880070311"},{"key":"e_1_2_1_27_2","first-page":"491","article-title":"The frequency of muscle involvement in myasthenia gravis correlates with mean muscle temperature","volume":"5","author":"Jablecki C","year":"1982","journal-title":"Muscle Nerve"},{"key":"e_1_2_1_28_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1476-5381.1957.tb00131.x"},{"key":"e_1_2_1_29_2","doi-asserted-by":"publisher","DOI":"10.1002\/ana.410120303"},{"key":"e_1_2_1_30_2","first-page":"65","article-title":"End\u2010plate potentials in human botulism (abstract)","volume":"334","author":"Lambert EH","year":"1974","journal-title":"Excerpta Medica. 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