{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,24]],"date-time":"2026-03-24T08:56:02Z","timestamp":1774342562856,"version":"3.50.1"},"reference-count":27,"publisher":"Wiley","issue":"5","license":[{"start":{"date-parts":[[2004,10,13]],"date-time":"2004-10-13T00:00:00Z","timestamp":1097625600000},"content-version":"vor","delay-in-days":5279,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Muscle and Nerve"],"published-print":{"date-parts":[[1990,5]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Although electromyography (EMG = nerve conduction and needle electromyographic examination) is among the most sensitive and reliable approaches to detect and even to characterize certain aspects of nerve disease, it is important for physicians to appreciate that EMG has limited value in (1) inferring symptoms and neuropathic deficit (particularly the overall deficit recorded by clinical neurologists), (2) inferring involvement of small\u2010diameter fibers, (3) inferring underlying biochemical or other pathophysiologic derangement, (4) inferring the presence and type and pathologic alterations in single fibers or Schwann cells, or (5) inferring interstitial pathologic abnormality. For 1 and 2, an adequate neurologic history and examination in needed. For 2, quantitative sensory (QSE) and quantitative autonomic (QAE) examination and histologic study of nerve often are especially helpful. For 3, clinical evaluation and a variety of laboratory examinations are needed. For 4 and 5, clinical evaluation and\/or pathologic study of nerve may be needed<\/jats:p><jats:p>Electromyography has deservedly gained considerable acceptance as a worthwhile evaluative procedure for the study of neuromuscular disease. For some purposes, however it is of limited value and other evaluative procedures are more informative. In this review, I trace the history of some of the reasons for the popularity of EMG and highlight some of its limitations. The purpose is not to diminish EMG or to elevate the procedure of nerve biopsy, rather to provide a conceptual framework for how these techniques and the clinical and other laboratory examinations can be used together in the assessment and follow\u2010up of neuropathy.<\/jats:p>","DOI":"10.1002\/mus.880130502","type":"journal-article","created":{"date-parts":[[2005,1,1]],"date-time":"2005-01-01T09:38:28Z","timestamp":1104572308000},"page":"371-375","source":"Crossref","is-referenced-by-count":30,"title":["Invited review: Limitations in predicting pathologic abnormality of nerves from the EMG examination"],"prefix":"10.1002","volume":"13","author":[{"given":"Peter James","family":"Dyck","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2004,10,13]]},"reference":[{"key":"e_1_2_1_2_2","doi-asserted-by":"publisher","DOI":"10.1038\/263786a0"},{"key":"e_1_2_1_3_2","doi-asserted-by":"publisher","DOI":"10.1113\/jphysiol.1978.sp012384"},{"key":"e_1_2_1_4_2","first-page":"981","volume-title":"Peripheral Neuropathy","author":"Buchthal F","year":"1984"},{"key":"e_1_2_1_5_2","doi-asserted-by":"publisher","DOI":"10.1016\/0166-2236(81)90046-1"},{"key":"e_1_2_1_6_2","first-page":"214","article-title":"Numbers and diameters of nerve fibers and compound action potential of sural nerve: Controls and hereditary neuromuscular disorders","volume":"91","author":"Dyck PJ","year":"1986","journal-title":"Trans ANA"},{"key":"e_1_2_1_7_2","doi-asserted-by":"publisher","DOI":"10.1001\/archneur.1969.00480110054005"},{"key":"e_1_2_1_8_2","first-page":"778","article-title":"Method of fascicular biopsy of human peripheral nerve for electrophysiologic and histologic study","volume":"41","author":"Dyck PJ","year":"1966","journal-title":"Mayo Clin Proc"},{"key":"e_1_2_1_9_2","doi-asserted-by":"publisher","DOI":"10.2337\/diacare.10.4.432"},{"key":"e_1_2_1_10_2","unstructured":"DyckPJ KarnesJ LambertEH:Longitudinal study of neuropathic deficits in hereditary motor and sensory neuropathy type 1.Neurology(in press)."},{"key":"e_1_2_1_11_2","doi-asserted-by":"publisher","DOI":"10.1212\/WNL.13.1.1"},{"key":"e_1_2_1_12_2","first-page":"107","volume-title":"Diabetic Neuropathy","author":"Dyck PJ","year":"1987"},{"key":"e_1_2_1_13_2","first-page":"83","volume-title":"Handbook of Electroencephalography and Clinical Neurophysiology","author":"Dyck PJ","year":"1971"},{"key":"e_1_2_1_14_2","first-page":"1103","volume-title":"Peripheral Neuropathy","author":"Dyck PJ","year":"1984"},{"key":"e_1_2_1_15_2","first-page":"697","article-title":"Computer assisted sensory examination to detect and quantitate sensory deficit in diabetic neuropathy","volume":"5","author":"Dyck PJ","year":"1983","journal-title":"Neurobehavioral Toxicology and Teratology"},{"key":"e_1_2_1_16_2","doi-asserted-by":"publisher","DOI":"10.1093\/brain\/106.2.373"},{"key":"e_1_2_1_17_2","doi-asserted-by":"crossref","first-page":"522","DOI":"10.1152\/ajplegacy.1927.80.3.522","article-title":"The role played by the sizes of the constituent fibers of a nerve trunk in determining the form of its action potential wave","volume":"80","author":"Gasser HS","year":"1927","journal-title":"Am J Physiol"},{"key":"e_1_2_1_18_2","first-page":"919","volume-title":"Peripheral Neuropathy","author":"Kimura J","year":"1984"},{"key":"e_1_2_1_19_2","volume-title":"Clinical Examinations in Neurology","author":"Lambert EH","year":"1963"},{"key":"e_1_2_1_20_2","first-page":"427","volume-title":"Peripheral Neuropathy","author":"Lambert EH","year":"1975"},{"key":"e_1_2_1_21_2","first-page":"1030","volume-title":"Peripheral Neuropathy","author":"Lambert EH","year":"1984"},{"key":"e_1_2_1_22_2","first-page":"171","volume-title":"Quantification of Neurologic Deficit","author":"Lindblom U","year":"1989"},{"key":"e_1_2_1_23_2","first-page":"1139","volume-title":"Peripheral Neuropathy","author":"Low PA","year":"1984"},{"key":"e_1_2_1_24_2","first-page":"140","volume-title":"Diabetic Neuropathy","author":"Low PA","year":"1987"},{"key":"e_1_2_1_25_2","doi-asserted-by":"publisher","DOI":"10.1001\/archneur.1973.00490250041005"},{"key":"e_1_2_1_26_2","first-page":"490","volume-title":"Basic and Clinical Electrophysiology","author":"Stampfli R","year":"1981"},{"key":"e_1_2_1_27_2","doi-asserted-by":"publisher","DOI":"10.1152\/ajplegacy.1939.127.2.211"},{"key":"e_1_2_1_28_2","first-page":"1745","volume-title":"Peripheral Neuropathy","author":"Thomas PK","year":"1984"}],"container-title":["Muscle &amp; Nerve"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1002%2Fmus.880130502","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/mus.880130502","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,10,23]],"date-time":"2023-10-23T01:46:47Z","timestamp":1698025607000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/mus.880130502"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[1990,5]]},"references-count":27,"journal-issue":{"issue":"5","published-print":{"date-parts":[[1990,5]]}},"alternative-id":["10.1002\/mus.880130502"],"URL":"https:\/\/doi.org\/10.1002\/mus.880130502","archive":["Portico"],"relation":{},"ISSN":["0148-639X","1097-4598"],"issn-type":[{"value":"0148-639X","type":"print"},{"value":"1097-4598","type":"electronic"}],"subject":[],"published":{"date-parts":[[1990,5]]}}}