{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,25]],"date-time":"2026-09-25T14:46:36Z","timestamp":1790347596395,"version":"4.1.0"},"reference-count":30,"publisher":"Wiley","issue":"6","license":[{"start":{"date-parts":[[2004,10,13]],"date-time":"2004-10-13T00:00:00Z","timestamp":1097625600000},"content-version":"vor","delay-in-days":4883,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Muscle and Nerve"],"published-print":{"date-parts":[[1991,6]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>In rabbits, the tibial nerve was exposed in the lower thigh under general anesthesia and cooled in a metal trough at 1 to 2\u00b0C or 5\u00b0C for 2, 3, or 4 hours. Nerve conduction studies showed local failure of conduction at the site of cooling which persisted after rewarming, and which was followed by distal degeneration of affected fibers. No persistent conduction block was seen. Changes in maximal velocity indicated that the fastest\u2010conducting motor and afferent axons had been preferentially affected. Histological finding in nerves examined at different intervals after cooling confirmed the physiological evidence of primary axonal damage, affecting particularly large diameter fibers. Paranodal demyelination was inconspicuous and restricted to regions just proximal to sites of axonal degeneration. No segmental demyelination was seen. These results clarify previous uncertainties as to the time\u2010course and distribution of nerve damage after local cooling at temperatures just above freezing point.<\/jats:p>","DOI":"10.1002\/mus.880140610","type":"journal-article","created":{"date-parts":[[2005,1,1]],"date-time":"2005-01-01T10:32:38Z","timestamp":1104575558000},"page":"553-562","source":"Crossref","is-referenced-by-count":19,"title":["Nerve conduction studies in experimental non\u2010freezing cold injury: I. Local nerve cooling"],"prefix":"10.1002","volume":"14","author":[{"given":"Robin P.","family":"Kennett","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Roger W.","family":"Gilliatt","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2004,10,13]]},"reference":[{"key":"e_1_2_1_2_2","doi-asserted-by":"publisher","DOI":"10.1016\/0887-8994(88)90025-2"},{"key":"e_1_2_1_3_2","doi-asserted-by":"publisher","DOI":"10.1016\/0022-510X(82)90182-4"},{"key":"e_1_2_1_4_2","doi-asserted-by":"publisher","DOI":"10.1016\/0022-510X(83)90065-5"},{"key":"e_1_2_1_5_2","doi-asserted-by":"publisher","DOI":"10.1007\/BF01474719"},{"key":"e_1_2_1_6_2","doi-asserted-by":"publisher","DOI":"10.1002\/bjs.18003112404"},{"key":"e_1_2_1_7_2","doi-asserted-by":"crossref","first-page":"138","DOI":"10.1093\/oxfordjournals.bmb.a071132","article-title":"Injury from exposure to low temperature: pathology","volume":"2","author":"Blackwood W","year":"1944","journal-title":"Br Med Bull"},{"key":"e_1_2_1_8_2","first-page":"385","article-title":"Experiments in the study of immersion foot","volume":"50","author":"Blackwood W","year":"1943","journal-title":"Edin Med J"},{"key":"e_1_2_1_9_2","first-page":"160","article-title":"Further experiments in the study of immersion foot","volume":"52","author":"Blackwood W","year":"1945","journal-title":"Edin Med J"},{"key":"e_1_2_1_10_2","doi-asserted-by":"publisher","DOI":"10.1113\/jphysiol.1972.sp009785"},{"key":"e_1_2_1_11_2","doi-asserted-by":"publisher","DOI":"10.1097\/00005072-194504040-00001"},{"key":"e_1_2_1_12_2","doi-asserted-by":"publisher","DOI":"10.1001\/archneurpsyc.1944.02290250007001"},{"key":"e_1_2_1_13_2","doi-asserted-by":"publisher","DOI":"10.1016\/0022-510X(81)90007-1"},{"key":"e_1_2_1_14_2","doi-asserted-by":"publisher","DOI":"10.1016\/0022-510X(79)90220-X"},{"key":"e_1_2_1_15_2","unstructured":"KennettRP:Non\u2010freezing cold injury: an experimental study in the tibial nerve of the rabbit. 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