{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,22]],"date-time":"2026-08-22T09:42:13Z","timestamp":1787391733089,"version":"build-2736575974"},"reference-count":26,"publisher":"Wiley","issue":"7","license":[{"start":{"date-parts":[[2004,10,13]],"date-time":"2004-10-13T00:00:00Z","timestamp":1097625600000},"content-version":"vor","delay-in-days":4853,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Muscle and Nerve"],"published-print":{"date-parts":[[1991,7]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>We used single fiber electromyography (SFEMG) to study 42 patients who had enroleld in a double\u2010blind, placebo\u2010controlled trial undertaken to assess the efficacy of botulinum toxin (BTX) injection of neck muscles to treat torticollis. SFEMG in a limb muscle was performed before treatment, 2, and 12 weeks after injection of placebo or BTX. Before treatment, the mean jitter was 26.8 \u03bcsec in patients who were to receive BTX, and 25.7 \u03bcsec in the placebo group. Two weeks after injection, mean jitter in the group receiving BTX was 43.6 \u03bcsec. In the placebo group, it was 26.5 \u03bcsec (<jats:italic>P<\/jats:italic> = &lt;.05). Twelve weeks after injection, mean jitter in the BTX group was 35.5; for the placebo group it was 24.5. Fiber density did not change in any patient during the study. There were no remote clinical effects of BTX. Injection of BTX into muscles affected with focal dystonia is a promising and safe treatment, but there are subclinical effects on uninjected muscles.<\/jats:p>","DOI":"10.1002\/mus.880140711","type":"journal-article","created":{"date-parts":[[2005,1,1]],"date-time":"2005-01-01T10:33:17Z","timestamp":1104575597000},"page":"672-675","source":"Crossref","is-referenced-by-count":125,"title":["Distant effects of locally injected botulinum toxin: A double\u2010blind study of single fiber EMG changes"],"prefix":"10.1002","volume":"14","author":[{"given":"Dale J.","family":"Lange","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Michael","family":"Rubin","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Paul E.","family":"Greene","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Un J.","family":"Kang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Carol B.","family":"Moskowitz","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mitchell F.","family":"Brin","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Robert E.","family":"Lovelace","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Stanley","family":"Fahn","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2004,10,13]]},"reference":[{"key":"e_1_2_1_2_2","doi-asserted-by":"publisher","DOI":"10.1056\/NEJM197908233010805"},{"key":"e_1_2_1_3_2","doi-asserted-by":"publisher","DOI":"10.1002\/mds.870040401"},{"key":"e_1_2_1_4_2","doi-asserted-by":"publisher","DOI":"10.1002\/mds.870020402"},{"key":"e_1_2_1_5_2","doi-asserted-by":"publisher","DOI":"10.1113\/expphysiol.1968.sp001948"},{"key":"e_1_2_1_6_2","first-page":"271","article-title":"Effect of treatment with botulinum toxin on neurogenic blepharospasm","volume":"35","author":"Elston JS","year":"1985","journal-title":"Neurology (NY)"},{"key":"e_1_2_1_7_2","doi-asserted-by":"publisher","DOI":"10.1001\/archopht.1984.01040031184014"},{"key":"e_1_2_1_8_2","doi-asserted-by":"publisher","DOI":"10.1212\/WNL.39.1.80"},{"key":"e_1_2_1_9_2","unstructured":"GreeneP KangU Fahn BrinM MoskowitzC FlasterE: Double\u2010blind placebo controlled study of botulinum toxin injection for torticollis.Neurology in press."},{"key":"e_1_2_1_10_2","doi-asserted-by":"publisher","DOI":"10.1212\/WNL.40.2.277"},{"key":"e_1_2_1_11_2","first-page":"467","article-title":"Botulinum A toxin in the treatment of blepharospasm","volume":"49","author":"Jankovic J","year":"1988","journal-title":"Adv Neurol"},{"key":"e_1_2_1_12_2","doi-asserted-by":"publisher","DOI":"10.1212\/WNL.37.4.616"},{"key":"e_1_2_1_13_2","doi-asserted-by":"publisher","DOI":"10.1002\/cpt196782286"},{"key":"e_1_2_1_14_2","doi-asserted-by":"publisher","DOI":"10.1002\/mus.880100610"},{"key":"e_1_2_1_15_2","first-page":"609","volume-title":"Advances in Neurology","author":"Lange DJ","year":"1988"},{"key":"e_1_2_1_16_2","doi-asserted-by":"publisher","DOI":"10.1212\/WNL.38.8.1220"},{"key":"e_1_2_1_17_2","doi-asserted-by":"publisher","DOI":"10.1212\/WNL.35.10.1499"},{"key":"e_1_2_1_18_2","doi-asserted-by":"publisher","DOI":"10.1212\/WNL.38.11.1780"},{"key":"e_1_2_1_19_2","doi-asserted-by":"publisher","DOI":"10.1002\/mus.880090904"},{"key":"e_1_2_1_20_2","doi-asserted-by":"publisher","DOI":"10.1212\/WNL.36.4.545"},{"key":"e_1_2_1_21_2","first-page":"734","article-title":"Botulinum toxin injection of eye muscles to correct strabismus","volume":"79","author":"Scott AB","year":"1981","journal-title":"Trans Am Ophthalmol Soc"},{"key":"e_1_2_1_22_2","volume-title":"Single Fiber Electromyography","author":"St\u00e5lberg E","year":"1979"},{"key":"e_1_2_1_23_2","doi-asserted-by":"publisher","DOI":"10.1093\/clinids\/1.4.656"},{"key":"e_1_2_1_24_2","doi-asserted-by":"publisher","DOI":"10.1136\/jnnp.51.7.920"},{"key":"e_1_2_1_25_2","doi-asserted-by":"publisher","DOI":"10.1017\/S031716710003540X"},{"key":"e_1_2_1_26_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(86)92070-2"},{"key":"e_1_2_1_27_2","doi-asserted-by":"publisher","DOI":"10.1016\/0002-9394(85)90228-4"}],"container-title":["Muscle &amp; Nerve"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1002%2Fmus.880140711","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/mus.880140711","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,10,23]],"date-time":"2023-10-23T02:49:18Z","timestamp":1698029358000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/mus.880140711"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[1991,7]]},"references-count":26,"journal-issue":{"issue":"7","published-print":{"date-parts":[[1991,7]]}},"alternative-id":["10.1002\/mus.880140711"],"URL":"https:\/\/doi.org\/10.1002\/mus.880140711","archive":["Portico"],"relation":{},"ISSN":["0148-639X","1097-4598"],"issn-type":[{"value":"0148-639X","type":"print"},{"value":"1097-4598","type":"electronic"}],"subject":[],"published":{"date-parts":[[1991,7]]}}}