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Testing for serum anti\u2010GM1 activity is indicated in the diagnostic evaluation of lower motor neuron syndromes. The presence of high titers of anti\u2010GM1 antibodies mandates careful electrophysiologic testing for the motor conduction block that is found in multifocal motor neuropathy, a treatable disorder. Quantitation of anti\u2010GM1 antibodies may also be a useful guide in the treatment of multifocal motor neuropathy. Further study of antiglycolipid antibodies in motor neuron disorders and peripheral neuropathies may provide clues to the events that stimulate these antibodies and to the pathogenesis of such syndromes.<\/jats:p>","DOI":"10.1002\/mus.880141002","type":"journal-article","created":{"date-parts":[[2005,1,1]],"date-time":"2005-01-01T10:31:27Z","timestamp":1104575487000},"page":"927-936","source":"Crossref","is-referenced-by-count":137,"title":["Invited review: Motor neuropathies, motor neuron disorders, and antiglycolipid antibodies"],"prefix":"10.1002","volume":"14","author":[{"given":"Alan Pestronk,","family":"Md","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2004,10,13]]},"reference":[{"key":"e_1_2_1_2_2","first-page":"299","article-title":"Predictive value of anti\u2010GM1 antibodies in neuromuscular diseases","volume":"40","author":"Adams D","year":"1990","journal-title":"Neurology"},{"key":"e_1_2_1_3_2","doi-asserted-by":"publisher","DOI":"10.1016\/0165-5728(89)90131-8"},{"key":"e_1_2_1_4_2","volume-title":"The Mode of Action of Immunosuppressive Agents","author":"Bach JF","year":"1985"},{"key":"e_1_2_1_5_2","doi-asserted-by":"publisher","DOI":"10.1001\/archneur.1989.00520440064022"},{"key":"e_1_2_1_6_2","doi-asserted-by":"publisher","DOI":"10.1016\/0167-5699(89)90268-5"},{"key":"e_1_2_1_7_2","first-page":"118","article-title":"Different patterns of glycolipid antibody reactivity: lower motor neuron syndromes vs immunization","volume":"40","author":"Chaudhry V","year":"1990","journal-title":"Neurology"},{"key":"e_1_2_1_8_2","doi-asserted-by":"crossref","first-page":"317","DOI":"10.1016\/S0260-4639(22)00182-7","article-title":"Anti\u2010inflammatory effects of corticosteroids","volume":"4","author":"Claman HN","year":"1984","journal-title":"Clin Immunol Allergy"},{"key":"e_1_2_1_9_2","series-title":"Fidia Research Series","first-page":"523","volume-title":"New Trends in Ganglioside Research: Neurochemical and Neuroregenerative Aspects","author":"Consolazione A","year":"1988"},{"key":"e_1_2_1_10_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1471-4159.1986.tb02852.x"},{"key":"e_1_2_1_11_2","doi-asserted-by":"publisher","DOI":"10.4049\/jimmunol.128.6.2453"},{"key":"e_1_2_1_12_2","first-page":"517","volume-title":"Cellular and Molecular Basis of Cholinergic Function","author":"Dolly JO","year":"1987"},{"key":"e_1_2_1_13_2","first-page":"61","article-title":"The influence of cyclophosphamide and 6\u2010mercaptopurine on the IgG1 and IgG2 immune response in guinea pigs","volume":"44","author":"Drossler K","year":"1981","journal-title":"Immunology"},{"key":"e_1_2_1_14_2","doi-asserted-by":"publisher","DOI":"10.1016\/0192-0561(83)90035-8"},{"key":"e_1_2_1_15_2","doi-asserted-by":"publisher","DOI":"10.1056\/NEJM198602203140801"},{"key":"e_1_2_1_16_2","first-page":"621","article-title":"Chronic inflammatory polyradiculoneuropathy","volume":"50","author":"Dyck PJ","year":"1975","journal-title":"Mayo Clin Proc"},{"key":"e_1_2_1_17_2","doi-asserted-by":"publisher","DOI":"10.1002\/ana.410110205"},{"key":"e_1_2_1_18_2","doi-asserted-by":"publisher","DOI":"10.1212\/WNL.35.8.1173"},{"key":"e_1_2_1_19_2","doi-asserted-by":"crossref","first-page":"1793","DOI":"10.4049\/jimmunol.132.4.1793","article-title":"Kundu SK, Marcus DM. 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