{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,25]],"date-time":"2026-09-25T14:46:26Z","timestamp":1790347586696,"version":"4.1.0"},"reference-count":24,"publisher":"Wiley","issue":"10","license":[{"start":{"date-parts":[[2004,10,13]],"date-time":"2004-10-13T00:00:00Z","timestamp":1097625600000},"content-version":"vor","delay-in-days":4761,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Muscle and Nerve"],"published-print":{"date-parts":[[1991,10]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>After immersion of the hind limb of the rabbit, up to the lower thigh, in a waterbath, at 1\u00b0C for 10 to 14 hours under light anesthesia, there was evidence of persistent nerve damage to the tibial nerve, which varied in severity in different animals. Nerve conduction studies, carried out within 24 hours of removal from the bath, showed that in a proportion of the motor and\/or afferent fibers, there was conduction failure between the knee and ankle. This was followed, over the next 48 hours, by distal degeneration of the affected fibers. No persistent conduction block was seen. After distal degeneration had occurred, maximal conduction velocity was mildly reduced, suggesting that the fastest\u2010conducting motor and afferent fibers had been particularly affected. Morphological studies confirmed preferential large myelinated fiber degeneration, the earliest lesions being seen in the leg at the level of the upper calf. Limb edema was not seen after cooling, and there was no histological evidence of muscle necrosis or damage to blood vessels. No abnormalities were seen in 4 control animals after hind limb immersion for 12 hours at temperatures of 30 to 35\u00b0C. Possible reasons for the proximal site of myelinated nerve fiber damage during hindlimb cooling are discussed.<\/jats:p>","DOI":"10.1002\/mus.880141006","type":"journal-article","created":{"date-parts":[[2005,1,1]],"date-time":"2005-01-01T10:31:27Z","timestamp":1104575487000},"page":"960-967","source":"Crossref","is-referenced-by-count":22,"title":["Nerve conduction studies in experimental non\u2010freezing cold injury: II. Generalized nerve cooling by limb immersion"],"prefix":"10.1002","volume":"14","author":[{"given":"Robin P.","family":"Kennett","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Roger W.","family":"Gilliatt","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2004,10,13]]},"reference":[{"key":"e_1_2_1_2_2","doi-asserted-by":"publisher","DOI":"10.1016\/0887-8994(88)90025-2"},{"key":"e_1_2_1_3_2","doi-asserted-by":"publisher","DOI":"10.1007\/BF01474719"},{"key":"e_1_2_1_4_2","first-page":"385","article-title":"Experiments in the study of immersion foot","volume":"50","author":"Blackwood W","year":"1943","journal-title":"Edin Med J"},{"key":"e_1_2_1_5_2","first-page":"160","article-title":"Further experiments in the study of immersion foot","volume":"52","author":"Blackwood W","year":"1945","journal-title":"Edin Med J"},{"key":"e_1_2_1_6_2","doi-asserted-by":"publisher","DOI":"10.1152\/ajplegacy.1953.172.3.639"},{"key":"e_1_2_1_7_2","doi-asserted-by":"publisher","DOI":"10.1097\/00005072-194504040-00001"},{"key":"e_1_2_1_8_2","doi-asserted-by":"publisher","DOI":"10.1016\/0022-510X(81)90007-1"},{"key":"e_1_2_1_9_2","doi-asserted-by":"publisher","DOI":"10.1136\/jnnp.5.3-4.81"},{"key":"e_1_2_1_10_2","doi-asserted-by":"publisher","DOI":"10.1016\/0022-510X(79)90220-X"},{"key":"e_1_2_1_11_2","doi-asserted-by":"publisher","DOI":"10.1086\/physzool.30.2.30155356"},{"key":"e_1_2_1_12_2","doi-asserted-by":"publisher","DOI":"10.1002\/mus.880140610"},{"key":"e_1_2_1_13_2","doi-asserted-by":"publisher","DOI":"10.1016\/0002-8703(48)90103-3"},{"key":"e_1_2_1_14_2","doi-asserted-by":"publisher","DOI":"10.1097\/00000658-194411000-00006"},{"key":"e_1_2_1_15_2","doi-asserted-by":"publisher","DOI":"10.1097\/00000441-195211000-00008"},{"key":"e_1_2_1_16_2","unstructured":"LundborgG: Ischaemic nerve injury: experimental studies on intraneural microvascular pathophysiology and nerve function in a limb subjected to temporary circulatory arrest.Scand J Plastic Reconstr Surg1970; (suppl 6):1\u2013113."},{"key":"e_1_2_1_17_2","doi-asserted-by":"publisher","DOI":"10.1016\/0010-406X(69)91314-0"},{"key":"e_1_2_1_18_2","doi-asserted-by":"publisher","DOI":"10.1093\/brain\/104.4.779"},{"key":"e_1_2_1_19_2","series-title":"International Congress Series No. 434","first-page":"308","volume-title":"Neurology","author":"Peyronnard JM","year":"1978"},{"key":"e_1_2_1_20_2","doi-asserted-by":"publisher","DOI":"10.1083\/jcb.17.1.208"},{"key":"e_1_2_1_21_2","first-page":"243","article-title":"Experimental immersion foot: observations in the chilled leg of the rabbit","volume":"19","author":"Sayen A","year":"1960","journal-title":"Clin Sci"},{"key":"e_1_2_1_22_2","doi-asserted-by":"publisher","DOI":"10.1001\/archneur.1967.00470190107013"},{"key":"e_1_2_1_23_2","doi-asserted-by":"publisher","DOI":"10.1002\/path.1700200113"},{"key":"e_1_2_1_24_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(00)58135-5"},{"key":"e_1_2_1_25_2","doi-asserted-by":"publisher","DOI":"10.1002\/bjs.18003312903"}],"container-title":["Muscle &amp; Nerve"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1002%2Fmus.880141006","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/mus.880141006","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,10,23]],"date-time":"2023-10-23T07:30:33Z","timestamp":1698046233000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/mus.880141006"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[1991,10]]},"references-count":24,"journal-issue":{"issue":"10","published-print":{"date-parts":[[1991,10]]}},"alternative-id":["10.1002\/mus.880141006"],"URL":"https:\/\/doi.org\/10.1002\/mus.880141006","archive":["Portico"],"relation":{},"ISSN":["0148-639X","1097-4598"],"issn-type":[{"value":"0148-639X","type":"print"},{"value":"1097-4598","type":"electronic"}],"subject":[],"published":{"date-parts":[[1991,10]]}}}