{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,11]],"date-time":"2026-04-11T10:40:43Z","timestamp":1775904043064,"version":"3.50.1"},"reference-count":25,"publisher":"Wiley","issue":"10","license":[{"start":{"date-parts":[[2004,10,13]],"date-time":"2004-10-13T00:00:00Z","timestamp":1097625600000},"content-version":"vor","delay-in-days":4761,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Muscle and Nerve"],"published-print":{"date-parts":[[1991,10]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Clinical correlations of antiganglioside GM1 antibodies are important because high titers of these antibodies may have therapeutic significance. To further evaluate this significance, we reviewed our experience with 78 patients who had the following diagnoses: amyotrophic lateral sclerosis (ALS), ALS syndromes in patients with gammopathy or thyroid abnormalities, cervical spondylosis simulating ALS, motor neuropathies, and chronic inflammatory demyelinating polyneuropathies (CIDP). Antiganglioside antibody titers were measured \u201cblind\u201d by ELISA assay at the neuromuscular clinical laboratory, Johns Hopkins School of Medicine. We conclude that anti\u2010GM1 antibodies are found in a wide variety of neuromuscular conditions. Patients with classical ALS had a mean anti\u2010GM1 antibody titer significantly lower than patients with CIDP or motor neuropathy. Patients with ALS associated with gammopathy or thyroid disorders had higher anti\u2010GM1 titers than seen in classical ALS. The highest mean titer occurred in patients with CIDP, a treatable neuropathy.<\/jats:p>","DOI":"10.1002\/mus.880141014","type":"journal-article","created":{"date-parts":[[2005,1,1]],"date-time":"2005-01-01T10:31:27Z","timestamp":1104575487000},"page":"1021-1027","source":"Crossref","is-referenced-by-count":47,"title":["Clinical correlations of Anti\u2010Gm1 antibodies in amyotrophic lateral sclerosis and neuropathies"],"prefix":"10.1002","volume":"14","author":[{"given":"Nancy L.","family":"Lamb","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Bernard M.","family":"Patten","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2004,10,13]]},"reference":[{"key":"e_1_2_1_2_2","doi-asserted-by":"publisher","DOI":"10.1001\/archneur.1986.00520030026007"},{"key":"e_1_2_1_3_2","doi-asserted-by":"publisher","DOI":"10.1016\/0165-5728(89)90131-8"},{"key":"e_1_2_1_4_2","doi-asserted-by":"publisher","DOI":"10.1002\/ana.410260214"},{"key":"e_1_2_1_5_2","doi-asserted-by":"crossref","first-page":"1793","DOI":"10.4049\/jimmunol.132.4.1793","article-title":"Antibodies to glycosphingolipids in patients with multiple sclerosis and SLE","volume":"132","author":"Endo T","year":"1984","journal-title":"J Immunol"},{"key":"e_1_2_1_6_2","doi-asserted-by":"publisher","DOI":"10.1212\/WNL.26.2.167"},{"key":"e_1_2_1_7_2","doi-asserted-by":"publisher","DOI":"10.1212\/WNL.36.4.454"},{"key":"e_1_2_1_8_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-0404.1987.tb07909.x"},{"key":"e_1_2_1_9_2","doi-asserted-by":"publisher","DOI":"10.1212\/WNL.37.4.717"},{"key":"e_1_2_1_10_2","doi-asserted-by":"publisher","DOI":"10.1016\/0165-5728(88)90006-9"},{"key":"e_1_2_1_11_2","doi-asserted-by":"publisher","DOI":"10.1212\/WNL.30.5.463"},{"key":"e_1_2_1_12_2","doi-asserted-by":"publisher","DOI":"10.1001\/archneur.1977.00500240062011"},{"key":"e_1_2_1_13_2","doi-asserted-by":"publisher","DOI":"10.1212\/WNL.38.5.763"},{"key":"e_1_2_1_14_2","doi-asserted-by":"publisher","DOI":"10.1007\/978-1-4684-7844-0_16"},{"key":"e_1_2_1_15_2","doi-asserted-by":"publisher","DOI":"10.1016\/0165-5728(89)90144-6"},{"key":"e_1_2_1_16_2","doi-asserted-by":"publisher","DOI":"10.1002\/ana.410230517"},{"key":"e_1_2_1_17_2","first-page":"99","article-title":"The syndromic nature of amyotrophic lateral sclerosis","volume":"209","author":"Patten BM","year":"1987","journal-title":"Adv Exp Med Biol"},{"key":"e_1_2_1_18_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-0404.1984.tb00802.x"},{"key":"e_1_2_1_19_2","doi-asserted-by":"publisher","DOI":"10.1212\/WNL.38.9.1457"},{"key":"e_1_2_1_20_2","doi-asserted-by":"publisher","DOI":"10.1002\/ana.410250118"},{"key":"e_1_2_1_21_2","doi-asserted-by":"publisher","DOI":"10.1002\/ana.410270314"},{"key":"e_1_2_1_22_2","doi-asserted-by":"publisher","DOI":"10.1002\/ana.410240113"},{"key":"e_1_2_1_23_2","doi-asserted-by":"publisher","DOI":"10.1002\/ana.410180111"},{"key":"e_1_2_1_24_2","doi-asserted-by":"publisher","DOI":"10.1001\/archneur.1985.04060030015004"},{"key":"e_1_2_1_25_2","first-page":"167","article-title":"Anti\u2010GM1 antibodies in motor neuron disease patients without plasma cell dyscrasia","volume":"22","author":"Shy ME","year":"1987","journal-title":"Ann Neurol"},{"key":"e_1_2_1_26_2","first-page":"252","article-title":"Motor neuropathy in a patient with autoantibodies against ganglioside GM1 and GD1b: Improvement following immunotherapy","volume":"38","author":"Shy ME","year":"1988","journal-title":"Neuropathy"}],"container-title":["Muscle &amp; Nerve"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1002%2Fmus.880141014","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/mus.880141014","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,10,23]],"date-time":"2023-10-23T07:29:54Z","timestamp":1698046194000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/mus.880141014"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[1991,10]]},"references-count":25,"journal-issue":{"issue":"10","published-print":{"date-parts":[[1991,10]]}},"alternative-id":["10.1002\/mus.880141014"],"URL":"https:\/\/doi.org\/10.1002\/mus.880141014","archive":["Portico"],"relation":{},"ISSN":["0148-639X","1097-4598"],"issn-type":[{"value":"0148-639X","type":"print"},{"value":"1097-4598","type":"electronic"}],"subject":[],"published":{"date-parts":[[1991,10]]}}}