{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,20]],"date-time":"2025-10-20T10:05:29Z","timestamp":1760954729806},"reference-count":18,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2004,10,13]],"date-time":"2004-10-13T00:00:00Z","timestamp":1097625600000},"content-version":"vor","delay-in-days":4609,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Muscle and Nerve"],"published-print":{"date-parts":[[1992,3]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>We performed in vitro microelectrode studies in the anconeus muscle biopsy of a 6\u2010week\u2010old infant intoxicated with <jats:italic>Clostridium botulinum<\/jats:italic> toxin B. The most striking abnormalities were the severe reduction of the endplate potential (EPP) quantal content and the marked variability of EPP latencies. The increased variability was often limited to a \u201csingle quantum\u201d component of the EPP. Neither the amplitudes nor the frequencies of spontaneous miniature endplate potentials (MEEPs) were decreased. However, there was a wide range of amplitudes and frequencies of MEPPs. This unique combination of electrophysiologic findings indicates a severe presynaptic failure of neuromuscular transmission, which appears to result from an impairment of the process of synaptic vesicle release taking place after the stimulus induced influx of calcium into the motor nerve terminals.<\/jats:p>","DOI":"10.1002\/mus.880150303","type":"journal-article","created":{"date-parts":[[2005,1,1]],"date-time":"2005-01-01T03:14:56Z","timestamp":1104549296000},"page":"273-276","source":"Crossref","is-referenced-by-count":17,"title":["In vitro microelectrode study of neuromuscular transmission in a case of botulism"],"prefix":"10.1002","volume":"15","author":[{"given":"Ricardo A.","family":"Maselli","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Margaret E.","family":"Burnett","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"James H.","family":"Tonsgard","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2004,10,13]]},"reference":[{"key":"e_1_2_1_2_2","doi-asserted-by":"publisher","DOI":"10.1113\/jphysiol.1974.sp010608"},{"key":"e_1_2_1_3_2","doi-asserted-by":"publisher","DOI":"10.1113\/jphysiol.1954.sp005067"},{"key":"e_1_2_1_4_2","doi-asserted-by":"publisher","DOI":"10.1113\/jphysiol.1956.sp005642"},{"key":"e_1_2_1_5_2","doi-asserted-by":"publisher","DOI":"10.1113\/jphysiol.1949.sp004364"},{"key":"e_1_2_1_6_2","doi-asserted-by":"publisher","DOI":"10.1113\/jphysiol.1976.sp011510"},{"key":"e_1_2_1_7_2","doi-asserted-by":"publisher","DOI":"10.1007\/BF00583812"},{"key":"e_1_2_1_8_2","doi-asserted-by":"crossref","unstructured":"GuytonAC MacDonaldMA: Physiology of botulinus toxin.Arch Neurol Psychiatry Chicago1947;578\u2013592.","DOI":"10.1001\/archneurpsyc.1947.02300280072004"},{"key":"e_1_2_1_9_2","doi-asserted-by":"publisher","DOI":"10.1113\/jphysiol.1971.sp009582"},{"key":"e_1_2_1_10_2","doi-asserted-by":"publisher","DOI":"10.1126\/science.2447652"},{"key":"e_1_2_1_11_2","first-page":"65","article-title":"End\u2010plate potentials in human botulism","volume":"334","author":"Lambert EH","year":"1974","journal-title":"Excerpta Medica (Amsterdam)"},{"key":"e_1_2_1_12_2","doi-asserted-by":"publisher","DOI":"10.1007\/BF00657503"},{"key":"e_1_2_1_13_2","doi-asserted-by":"publisher","DOI":"10.1002\/mus.880141208"},{"key":"e_1_2_1_14_2","doi-asserted-by":"publisher","DOI":"10.1113\/jphysiol.1989.sp017573"},{"key":"e_1_2_1_15_2","doi-asserted-by":"publisher","DOI":"10.1002\/mus.880100514"},{"key":"e_1_2_1_16_2","first-page":"1201","volume-title":"AAEE Case Report","author":"Pickett JB","year":"1988"},{"key":"e_1_2_1_17_2","volume-title":"Single Fibre Electromyography. Old Woking","author":"St\u00e5lberg E","year":"1979"},{"key":"e_1_2_1_18_2","first-page":"192","article-title":"Transmitter release in botulinum\u2010poisoned muscles","volume":"79","author":"Thesleff S","year":"1984","journal-title":"J Physiol (Paris)"},{"key":"e_1_2_1_19_2","unstructured":"WrayDW LangB Newsom\u2010DavisJ PeersC: Antibodies against calcium channels in the Lambert\u2010Eaton Myasthenic Syndrome.Ann NY Acad Sci 1987."}],"container-title":["Muscle &amp; Nerve"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1002%2Fmus.880150303","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/mus.880150303","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,10,23]],"date-time":"2023-10-23T15:13:45Z","timestamp":1698074025000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/mus.880150303"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[1992,3]]},"references-count":18,"journal-issue":{"issue":"3","published-print":{"date-parts":[[1992,3]]}},"alternative-id":["10.1002\/mus.880150303"],"URL":"https:\/\/doi.org\/10.1002\/mus.880150303","archive":["Portico"],"relation":{},"ISSN":["0148-639X","1097-4598"],"issn-type":[{"value":"0148-639X","type":"print"},{"value":"1097-4598","type":"electronic"}],"subject":[],"published":{"date-parts":[[1992,3]]}}}