{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,2]],"date-time":"2026-04-02T01:43:22Z","timestamp":1775094202999,"version":"3.50.1"},"reference-count":16,"publisher":"Wiley","issue":"5","license":[{"start":{"date-parts":[[2004,10,13]],"date-time":"2004-10-13T00:00:00Z","timestamp":1097625600000},"content-version":"vor","delay-in-days":4548,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Muscle and Nerve"],"published-print":{"date-parts":[[1992,5]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>In an attempt to determine wheather lead (Pb) in striated muscle can be taken up by motor axon, mice were injected intramuscularly with a 5% nitrate solution, and the passage of Pb through the tissues was traced with electron mocroscopy. Thirty minutes after injection in the tibialis anterior muscle, Pb was seen at the sarcolemma and axolemma of the neuromuscular junction (NMJ) and in the adjacent sarcoplasmic reticulum (SR). Pb was also present in the axoplasm and mitochondria of terminal and preterminal motor axons. The presence of Pb was confirmed with x\u2010ray elemental microanalysis. The results indicate that there is a pathway for intramuscular Pb to enter terminal motor axons. This supports the hypothesis that some forms of motor neuron disease (MND) may be due to axonal uptake and retrograde transport of Pb.<\/jats:p>","DOI":"10.1002\/mus.880150514","type":"journal-article","created":{"date-parts":[[2005,1,1]],"date-time":"2005-01-01T10:36:11Z","timestamp":1104575771000},"page":"620-625","source":"Crossref","is-referenced-by-count":8,"title":["Lead uptake in motor axons"],"prefix":"10.1002","volume":"15","author":[{"given":"Roger","family":"Pamphlett","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Alexandra","family":"Bayliss","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2004,10,13]]},"reference":[{"key":"e_1_2_1_2_2","doi-asserted-by":"publisher","DOI":"10.1212\/WNL.31.5.612"},{"key":"e_1_2_1_3_2","doi-asserted-by":"publisher","DOI":"10.1016\/0022-510X(76)90175-1"},{"key":"e_1_2_1_4_2","doi-asserted-by":"publisher","DOI":"10.1083\/jcb.17.3.571"},{"key":"e_1_2_1_5_2","first-page":"203","article-title":"Electron microscopic localization of the \u201clead\u2010reactive substance\u201d in the myoneural junction","volume":"15","author":"Csillik B","year":"1964","journal-title":"Acta Biol Hung"},{"key":"e_1_2_1_6_2","doi-asserted-by":"publisher","DOI":"10.1152\/physrev.1980.60.4.1167"},{"key":"e_1_2_1_7_2","doi-asserted-by":"publisher","DOI":"10.1083\/jcb.57.2.315"},{"key":"e_1_2_1_8_2","doi-asserted-by":"publisher","DOI":"10.1007\/BF00690948"},{"key":"e_1_2_1_9_2","doi-asserted-by":"publisher","DOI":"10.1016\/0006-8993(84)91313-1"},{"key":"e_1_2_1_10_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0733-8619(18)30934-4"},{"key":"e_1_2_1_11_2","doi-asserted-by":"publisher","DOI":"10.1177\/15.5.276"},{"key":"e_1_2_1_12_2","first-page":"231","article-title":"On the affinity of the divalent metal cation for the neuromuscular junction","volume":"28","author":"Nakamura T","year":"1979","journal-title":"J Electron Microsc (Tokyo)"},{"key":"e_1_2_1_13_2","doi-asserted-by":"publisher","DOI":"10.2535\/ofaj1936.60.2-3_161"},{"key":"e_1_2_1_14_2","doi-asserted-by":"publisher","DOI":"10.1038\/1811137a0"},{"key":"e_1_2_1_15_2","doi-asserted-by":"publisher","DOI":"10.1007\/BF02158974"},{"key":"e_1_2_1_16_2","first-page":"715","article-title":"Subcellular localization of lead in synaptosomes","volume":"17","author":"Silbergeld EK","year":"1977","journal-title":"Res Commun Chem Path Pharmacol"},{"key":"e_1_2_1_17_2","doi-asserted-by":"publisher","DOI":"10.1038\/243100a0"}],"container-title":["Muscle &amp; Nerve"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1002%2Fmus.880150514","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/mus.880150514","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,10,24]],"date-time":"2023-10-24T03:00:54Z","timestamp":1698116454000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/mus.880150514"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[1992,5]]},"references-count":16,"journal-issue":{"issue":"5","published-print":{"date-parts":[[1992,5]]}},"alternative-id":["10.1002\/mus.880150514"],"URL":"https:\/\/doi.org\/10.1002\/mus.880150514","archive":["Portico"],"relation":{},"ISSN":["0148-639X","1097-4598"],"issn-type":[{"value":"0148-639X","type":"print"},{"value":"1097-4598","type":"electronic"}],"subject":[],"published":{"date-parts":[[1992,5]]}}}