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We investigated the effect of zidovudine on proliferation, differentiation, activity of mitochondrial\u2010 and nuclear\u2010encoded enzymes, and mitochondrial DNA (mtDNA), in cultured human muscle cells. Marked inhibition of cell proliferation was found, even in the presence of low (10 \u03bcmol\/L) zidovudine concentrations. Enzyme activity of the nuclear\u2010encoded mitochondrial citrate synthase was not affected, and the partially mitochondrial\u2010encoded cytochrome c oxidase was not decreased, except only after exposure to high concentrations (5 mmol\/L) zidovudine. No decrease of mtDNA content and no mtDNA deletions were found in zidovudine\u2010exposed muscle cells. We propose that the effect of zidovudine on muscle, seen in zidovudine\u2010treated AIDS patients, results mainly from decrease in proliferation of muscle cells rather than inhibition of mtDNA replication.<\/jats:p>","DOI":"10.1002\/mus.880150613","type":"journal-article","created":{"date-parts":[[2005,1,1]],"date-time":"2005-01-01T10:36:51Z","timestamp":1104575811000},"page":"706-710","source":"Crossref","is-referenced-by-count":26,"title":["Major growth reduction and minor decrease in mitochondrial enzyme activity in cultured human muscle cells after exposure to zidovudine"],"prefix":"10.1002","volume":"15","author":[{"given":"Nicole H.","family":"Herzberg","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ina","family":"Zorn","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Rob","family":"Zwart","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Peter","family":"Portegies","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Pieter A.","family":"Bolhuis","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2004,10,13]]},"reference":[{"key":"e_1_2_1_2_2","doi-asserted-by":"publisher","DOI":"10.1016\/0140-6736(91)91294-5"},{"key":"e_1_2_1_3_2","doi-asserted-by":"publisher","DOI":"10.1056\/NEJM198803173181113"},{"key":"e_1_2_1_4_2","doi-asserted-by":"publisher","DOI":"10.1002\/mus.880080105"},{"key":"e_1_2_1_5_2","doi-asserted-by":"publisher","DOI":"10.1016\/0005-2787(67)90697-1"},{"key":"e_1_2_1_6_2","doi-asserted-by":"publisher","DOI":"10.1016\/0003-2697(76)90527-3"},{"key":"e_1_2_1_7_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0021-9258(18)44883-1"},{"key":"e_1_2_1_8_2","doi-asserted-by":"publisher","DOI":"10.1056\/NEJM198712173172511"},{"key":"e_1_2_1_9_2","doi-asserted-by":"publisher","DOI":"10.1002\/ana.410230713"},{"key":"e_1_2_1_10_2","doi-asserted-by":"publisher","DOI":"10.1056\/NEJM199004193221602"},{"key":"e_1_2_1_11_2","doi-asserted-by":"publisher","DOI":"10.1016\/0140-6736(90)92875-I"},{"key":"e_1_2_1_12_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(88)91865-X"},{"key":"e_1_2_1_13_2","doi-asserted-by":"publisher","DOI":"10.1016\/0006-291X(91)90893-C"},{"key":"e_1_2_1_14_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(88)90506-5"},{"key":"e_1_2_1_15_2","doi-asserted-by":"publisher","DOI":"10.3109\/00365517909104932"},{"key":"e_1_2_1_16_2","doi-asserted-by":"publisher","DOI":"10.1016\/0092-8674(88)90423-0"},{"key":"e_1_2_1_17_2","first-page":"696","article-title":"An improved procedure for serum creatine phosphokinase determination","volume":"69","author":"Rosalki SB","year":"1967","journal-title":"J Lab Clin Med"},{"key":"e_1_2_1_18_2","doi-asserted-by":"publisher","DOI":"10.1002\/ana.410240114"},{"key":"e_1_2_1_19_2","doi-asserted-by":"publisher","DOI":"10.1016\/0006-2952(89)90245-1"},{"key":"e_1_2_1_20_2","doi-asserted-by":"publisher","DOI":"10.1016\/0076-6879(69)13005-0"},{"key":"e_1_2_1_21_2","doi-asserted-by":"publisher","DOI":"10.1002\/jcp.1041210218"},{"key":"e_1_2_1_22_2","doi-asserted-by":"publisher","DOI":"10.1056\/NEJM198909143211106"},{"key":"e_1_2_1_23_2","doi-asserted-by":"publisher","DOI":"10.1016\/0022-510X(77)90018-1"},{"key":"e_1_2_1_24_2","doi-asserted-by":"crossref","first-page":"11847","DOI":"10.1016\/S0021-9258(19)70211-7","article-title":"Mitochondrial DNA replication does not involve DNA polymerase \u03b1","volume":"255","author":"Zimmerman W","year":"1980","journal-title":"J Biol Chem"}],"container-title":["Muscle &amp; Nerve"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1002%2Fmus.880150613","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/mus.880150613","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,10,23]],"date-time":"2023-10-23T20:52:27Z","timestamp":1698094347000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/mus.880150613"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[1992,6]]},"references-count":23,"journal-issue":{"issue":"6","published-print":{"date-parts":[[1992,6]]}},"alternative-id":["10.1002\/mus.880150613"],"URL":"https:\/\/doi.org\/10.1002\/mus.880150613","archive":["Portico"],"relation":{},"ISSN":["0148-639X","1097-4598"],"issn-type":[{"value":"0148-639X","type":"print"},{"value":"1097-4598","type":"electronic"}],"subject":[],"published":{"date-parts":[[1992,6]]}}}