{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,11,2]],"date-time":"2025-11-02T10:16:48Z","timestamp":1762078608106},"reference-count":32,"publisher":"Wiley","issue":"8","license":[{"start":{"date-parts":[[2004,10,13]],"date-time":"2004-10-13T00:00:00Z","timestamp":1097625600000},"content-version":"vor","delay-in-days":4456,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Muscle and Nerve"],"published-print":{"date-parts":[[1992,8]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>The effects of phenytoin treatment were evaluated in 2 myotonic horses with hyperkalemic periodic paralysis (HPP). Phenytoin treatment abolished the clinical signs of muscle fasciculations following oral potassium challenge and decreased or abolished repetitive firing and myotonic discharges found on electromyographic examination. In both horses, an abnormally low threshold for calcium\u2010induced calcium release was measured in heavy sarcoplasmic reticulum fractions from skeletal muscle, and this threshold increased with phenytoin treatment. Results suggest phenytoin is useful in modifying disordered ion regulation in the sarcolemma and sarcoplasmic reticulum of skeletal muscle in equine hyperkalemic periodic paralysis. \u00a9 1992 John Wiley &amp; Sons, Inc.<\/jats:p>","DOI":"10.1002\/mus.880150811","type":"journal-article","created":{"date-parts":[[2005,1,1]],"date-time":"2005-01-01T10:38:46Z","timestamp":1104575926000},"page":"932-936","source":"Crossref","is-referenced-by-count":23,"title":["Effects of phenytoin in two myotonic horses with hyperkalemic periodic paralysis"],"prefix":"10.1002","volume":"15","author":[{"given":"Jill","family":"Beech","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jeffrey E.","family":"Fletcher","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Linda","family":"Tripolitis","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sue","family":"Lindborg","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2004,10,13]]},"reference":[{"key":"e_1_2_1_2_2","first-page":"2130","article-title":"Effect of phenytoin on the clinical signs and in vitro muscle twitch characteristics in horses with chronic intermittent rhabdomyolysis and myotonia","volume":"49","author":"Beech J","year":"1988","journal-title":"Am J Vet Res"},{"key":"e_1_2_1_3_2","article-title":"Ca2+\u2010induced Ca2+ release (CICR) in skeletal muscle from horses with chronic intermittent rhabdomyolysis (CIR)","volume":"4","author":"Beech J","year":"1990","journal-title":"FASEB J"},{"key":"e_1_2_1_4_2","doi-asserted-by":"publisher","DOI":"10.1016\/0896-6273(91)90064-7"},{"key":"e_1_2_1_5_2","first-page":"83","article-title":"Episodic weakness caused by hyperkalemic periodic paralysis in horses","volume":"12","author":"Cox JH","year":"1990","journal-title":"Comp Contin Educ"},{"key":"e_1_2_1_6_2","doi-asserted-by":"publisher","DOI":"10.1139\/o90-177"},{"key":"e_1_2_1_7_2","doi-asserted-by":"publisher","DOI":"10.1126\/science.2173143"},{"key":"e_1_2_1_8_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1471-4159.1985.tb08754.x"},{"key":"e_1_2_1_9_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2885.1983.tb00390.x"},{"key":"e_1_2_1_10_2","doi-asserted-by":"publisher","DOI":"10.1093\/bja\/65.5.692"},{"key":"e_1_2_1_11_2","doi-asserted-by":"publisher","DOI":"10.1007\/BF00370530"},{"key":"e_1_2_1_12_2","doi-asserted-by":"publisher","DOI":"10.1002\/mus.880060206"},{"key":"e_1_2_1_13_2","doi-asserted-by":"publisher","DOI":"10.1002\/mus.880100414"},{"key":"e_1_2_1_14_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0021-9258(19)52451-6"},{"key":"e_1_2_1_15_2","doi-asserted-by":"publisher","DOI":"10.1016\/0003-2697(78)90586-9"},{"key":"e_1_2_1_16_2","doi-asserted-by":"publisher","DOI":"10.1152\/physrev.1984.64.4.1240"},{"key":"e_1_2_1_17_2","doi-asserted-by":"publisher","DOI":"10.1016\/0006-291X(86)90439-0"},{"key":"e_1_2_1_18_2","first-page":"1026","article-title":"Hyperkalemic periodic paresis may be inherited as an autosomal dominant trait with incomplete penetrance","volume":"7","author":"Naylor JM","year":"1989","journal-title":"Proceedings of the American College Veterinary Internal Medicine Forum"},{"key":"e_1_2_1_19_2","doi-asserted-by":"publisher","DOI":"10.1172\/JCI111057"},{"key":"e_1_2_1_20_2","doi-asserted-by":"publisher","DOI":"10.1016\/0014-5793(83)80739-X"},{"key":"e_1_2_1_21_2","doi-asserted-by":"crossref","first-page":"6135","DOI":"10.1016\/S0021-9258(18)45548-2","article-title":"Drug induced calcium release from isolated sarcoplasmic reticulum. 1. Use of pyrophosphate to study caffeine induced Ca2+ release","volume":"262","author":"Palade P","year":"1987","journal-title":"J Biol Chem"},{"key":"e_1_2_1_22_2","doi-asserted-by":"publisher","DOI":"10.1152\/ajpcell.1991.260.5.C926"},{"key":"e_1_2_1_23_2","doi-asserted-by":"publisher","DOI":"10.1016\/0014-4886(86)90255-4"},{"key":"e_1_2_1_24_2","doi-asserted-by":"publisher","DOI":"10.1016\/0006-8993(86)91373-9"},{"key":"e_1_2_1_25_2","first-page":"378","article-title":"Analysis in a large hyperkalemic periodic paralysis pedigree supports tight linkage to a sodium channel locus","volume":"49","author":"Ptacek LJ","year":"1991","journal-title":"Am J Hum Genet"},{"key":"e_1_2_1_26_2","doi-asserted-by":"publisher","DOI":"10.1016\/0143-4160(90)90012-J"},{"key":"e_1_2_1_27_2","first-page":"495","article-title":"Use of electromyography for the diagnosis of equine hyperkalemic periodic paralysis","volume":"54","author":"Robinson JA","year":"1990","journal-title":"Can J Vet Res"},{"key":"e_1_2_1_28_2","doi-asserted-by":"publisher","DOI":"10.1002\/mus.880120405"},{"key":"e_1_2_1_29_2","doi-asserted-by":"crossref","first-page":"1009","DOI":"10.2460\/javma.1990.197.08.1009","article-title":"Hyperkalemic periodic paralysis in horses","volume":"197","author":"Spier SJ","year":"1990","journal-title":"J Am Vet Med Assoc"},{"key":"e_1_2_1_30_2","first-page":"384","article-title":"The composition and calcium transport activity of the sarcoplasmic reticulum from goats with and without heritable myotonia","volume":"40","author":"Swift LL","year":"1979","journal-title":"Lab Invest"},{"key":"e_1_2_1_31_2","doi-asserted-by":"publisher","DOI":"10.1172\/JCI114073"},{"key":"e_1_2_1_32_2","first-page":"189","article-title":"Mechanisms of calcium channel block by phenytoin","volume":"246","author":"Twombly DA","year":"1988","journal-title":"J Pharmacol Exp Ther"},{"key":"e_1_2_1_33_2","first-page":"228","article-title":"Inhibition of voltage\u2010sensitive sodium channels in neuroblastoma cells and synaptosomes by the anticonvulsant drugs diphenylhydantion and carbamazepine","volume":"25","author":"Willow M","year":"1984","journal-title":"Mol Pharmacol"}],"container-title":["Muscle &amp; Nerve"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1002%2Fmus.880150811","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/mus.880150811","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,1,17]],"date-time":"2024-01-17T21:26:33Z","timestamp":1705526793000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/mus.880150811"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[1992,8]]},"references-count":32,"journal-issue":{"issue":"8","published-print":{"date-parts":[[1992,8]]}},"alternative-id":["10.1002\/mus.880150811"],"URL":"https:\/\/doi.org\/10.1002\/mus.880150811","archive":["Portico"],"relation":{},"ISSN":["0148-639X","1097-4598"],"issn-type":[{"value":"0148-639X","type":"print"},{"value":"1097-4598","type":"electronic"}],"subject":[],"published":{"date-parts":[[1992,8]]}}}