{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,8]],"date-time":"2025-10-08T16:16:11Z","timestamp":1759940171376},"reference-count":27,"publisher":"Wiley","issue":"11","license":[{"start":{"date-parts":[[2004,10,13]],"date-time":"2004-10-13T00:00:00Z","timestamp":1097625600000},"content-version":"vor","delay-in-days":4364,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Muscle and Nerve"],"published-print":{"date-parts":[[1992,11]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>In skeletal muscles from rats treated with germanium for 23 weeks, there were numerous ragged\u2010red fibers and cytochrome\u2010<jats:italic>c<\/jats:italic> oxidase (COX)\u2010deficient fibers. Biochemically, germanium reduced the enzyme activities in the mitochondrial respiratory chain. Rotenone\u2010sensitive NADH\u2013cytochrome\u2010<jats:italic>c<\/jats:italic> reductase as well as COX activities were markedly reduced, while succinate\u2013cytochrome\u2010<jats:italic>c<\/jats:italic> reductase was less severely, but significantly, affected. The histopathological findings in these muslces were similar to those seen in patients with mitochondrial encephalomyopathy, suggesting that germanium\u2010induced myopathy may be a useful experimental model. Coenzyme Q<jats:sub>10<\/jats:sub> administration appeared to be ineffective in preventing this experimental myopathy. \u00a9 1992 John Wiley &amp; Sons, Inc.<\/jats:p>","DOI":"10.1002\/mus.880151107","type":"journal-article","created":{"date-parts":[[2005,1,1]],"date-time":"2005-01-01T09:58:31Z","timestamp":1104573511000},"page":"1258-1264","source":"Crossref","is-referenced-by-count":21,"title":["An experimental model of mitochondrial myopathy: Germanium\u2010induced myopathy and coenzyme Q<sub>10<\/sub> 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